Abstract: Provided herein are compounds and methods for the treatment of cancer. The methods include administering to a subject in need a therapeutically effective amount of a Chk1 inhibitor disclosed herein.
Type:
Grant
Filed:
June 1, 2023
Date of Patent:
January 20, 2026
Assignee:
BOUNDLESS BIO, INC.
Inventors:
Anthony B. Pinkerton, Stephen Todd Meyer, Jacques Mauger, Yen Pham Hong Truong, Rachelle Janette Elsdon
Abstract: Provided herein are methods of treating cancer in a subject, wherein the cancer is extrachromosomal DNA-positive (ecDNA-positive) or therapeutically resistant, the method comprising administering to the subject a therapeutically effective amount of a replication stress (RS) pathway agent alone or in combination with a targeted therapeutic.
Type:
Grant
Filed:
March 24, 2023
Date of Patent:
March 11, 2025
Assignee:
BOUNDLESS BIO, INC.
Inventors:
Christian Hassig, Ryan Hansen, Snezana Milutinovic, Jason Christiansen, Zachary D. Hornby, Sudhir Chowdhry, Anthony Celeste, Kristen Turner, Deepti Wilkinson
Abstract: Provided herein are compounds and methods for the treatment of cancer. The methods include administering to a subject in need a therapeutically effective amount of a Chk1 inhibitor disclosed herein.
Type:
Grant
Filed:
August 29, 2022
Date of Patent:
July 25, 2023
Assignee:
BOUNDLESS BIO, INC.
Inventors:
Anthony B. Pinkerton, Stephen Todd Meyer, Jacques Mauger, Yen Pham Hong Truong, Rachelle Janette Elsdon
Abstract: Provided herein are methods of treating cancer in a subject, wherein the cancer is extrachromosomal DNA-positive (ecDNA-positive) or therapeutically resistant, the method comprising administering to the subject a therapeutically effective amount of a replication stress (RS) pathway agent alone or in combination with a targeted therapeutic.
Type:
Grant
Filed:
October 21, 2022
Date of Patent:
May 9, 2023
Assignee:
BOUNDLESS BIO, INC.
Inventors:
Christian Hassig, Ryan Hansen, Snezana Milutinovic, Jason Christiansen, Zachary Hornby, Sudhir Chowdhry, Anthony Celeste, Kristen Turner, Deepti Wilkinson
Abstract: Provided herein are methods of treating cancer in a subject, wherein the cancer is extrachromosomal DNA-positive (ecDNA-positive) or therapeutically resistant, the method comprising administering to the subject a therapeutically effective amount of a replication stress (RS) pathway agent alone or in combination with a targeted therapeutic.
Type:
Grant
Filed:
January 4, 2022
Date of Patent:
January 10, 2023
Assignee:
BOUNDLESS BIO, INC.
Inventors:
Christian Hassig, Ryan Hansen, Snezana Milutinovic, Jason Christiansen, Zachary Hornby, Sudhir Chowdhry, Anthony Celeste, Kristen Turner, Deepti Wilkinson