Patents Assigned to Bracco International B.V.
  • Process for the preparation of an intermediate useful in the synthesis of iodinated contrast media
    Patent number: 6100425
    Abstract: A process for the preparation of the compound L-5-(2-acetoxypropionylamino)-2,4,6-triiodoisophthaloyl dichloride by reacting 5-amino-2,4,6-triiodoisophthaloyl dichloride with L-2-acetoxypropionyl chloride in N,N-dimethylacetamide as a solvent, characterized in that a catalytic amount of a lower alcohol is added to the reaction mixture.
    Type: Grant
    Filed: December 19, 1997
    Date of Patent: August 8, 2000
    Assignee: Bracco International, B.V.
    Inventors: Marco Villa, Maurizio Paiocchi
  • Process for the crystallization from a linear or branched (C5-C6) alcohol or their mixtures of (S)-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyy l)amino]-2,4,6-triiodo-1,3-benzendicarboxamide
    Patent number: 6037494
    Abstract: Disclosed is a new process for the crystallization of (S)-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)a mino]-2,4,6-triiodo-1,3-benzendicarboxamide (I), using a linear or branched (C5-C6) alcohol or their mixtures.
    Type: Grant
    Filed: February 9, 1998
    Date of Patent: March 14, 2000
    Assignee: Bracco International B.V.
    Inventor: Nicola Desantis
  • Process for the preparation of 2-amino-1,3-propanediol
    Patent number: 5922917
    Abstract: A process for the preparation of 2-amino-1,3-propanediol comprising the catalytic hydrogenation of 1,3-dihydroxyacetone oxime in the presence of rhodium supported on alumina is described.
    Type: Grant
    Filed: September 19, 1996
    Date of Patent: July 13, 1999
    Assignee: Bracco International B.V.
    Inventors: Antonio Nardi, Marco Villa
  • Stable microbubbles suspensions injectable into living organisms
    Patent number: 5911972
    Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.
    Type: Grant
    Filed: February 11, 1998
    Date of Patent: June 15, 1999
    Assignee: Bracco International B.V.
    Inventors: Michel Schneider, Daniel Bichon, Philippe Bussat, Jerome Puginier, Eva Hybl-Sutherland
  • Stable microbubble suspensions comprising saturated phospholipios for ultrasonic echography
    Patent number: 5908610
    Abstract: Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabiliser of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.
    Type: Grant
    Filed: June 26, 1997
    Date of Patent: June 1, 1999
    Assignee: Bracco International B.V.
    Inventors: Michel Schneider, Jean Brochot, Jerome Puginier, Feng Yan
  • Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures
    Patent number: 5869024
    Abstract: In accordance with the present invention a novel method and composition for using nonionic contrast media to reduce the risk of clot formation in a diagnostic procedure is disclosed. Novel compositions for such method are also disclosed. The present method comprises employing a triiodinated phenyl contrast agent having a heterocyclic group or a dimeric triiodinated phenyl contrast agent having one or more heterocyclic groups.
    Type: Grant
    Filed: June 5, 1992
    Date of Patent: February 9, 1999
    Assignee: Bracco International B.V.
    Inventors: Ramachandran S. Ranganathan, Michael F. Tweedle, Paul W. Wedeking
  • Method of echographic imaging using polymeric gas or air filled microballoons
    Patent number: 5863520
    Abstract: Ultrasonic echographic imaging body organs using gas or air filled microballoons having a mean size in the range of 0.5 to 1000 microns bounded by a 50 to 500 nm thick biodegradable, interfacially deposited, synthetic polymer membrane which is both deformable and resilient are described.
    Type: Grant
    Filed: March 4, 1997
    Date of Patent: January 26, 1999
    Assignee: Bracco International B.V.
    Inventors: Daniel Bichon, Philippe Bussat, Michel Schneider
  • Process for preparing 5-amino-2,4,6-triiodoisophthalic acid dichloride by chlorination of the corresponding acid in the presence of a tertiary amine salt or quaternary ammonium salt
    Patent number: 5856570
    Abstract: A process for the preparation of 5-amino-2,4,6-triiodoisophthalic acid dichloride by chlorinating 5-amino-2,4,6-triiodoisophthalic acid with thionyl chloride in the presence of a suitable solvent and of a tertiary amine salt or quaternary ammonium salt in a molar ratio from 1;1 to 1;2 with respect to 5-amino-2,4,6-triiodoisophathalic acid is described. 5-amino-2,4,6-triiodoisophthalic acid dichloride is an intermediate useful for the preparation of iodinated contrast agents.
    Type: Grant
    Filed: May 29, 1997
    Date of Patent: January 5, 1999
    Assignee: Bracco International B.V.
    Inventors: Vincenzo Cannata, Corrado Velgi, Giuseppe Barreca
  • Ultrasonic contrast agent with polymeric gas or air filled microballoons
    Patent number: 5840275
    Abstract: Ultrasonic contrast compositions containing gas or air filled microballoons having a mean size in the range of 0.5 to 1000 microns bounded by a 50 to 500 nm thick biodegradable, interfacially deposited, synthetic polymer membrane which is deformable and resilient in an aqueous carrier liquid are described.
    Type: Grant
    Filed: August 16, 1994
    Date of Patent: November 24, 1998
    Assignee: Bracco International B.V.
    Inventors: Daniel Bichon, Philippe Bussat, Michel Schneider
  • Rhenium and technetium complexes containing a hypoxia localizing moiety
    Patent number: 5808091
    Abstract: Novel methods, processes and metal complexes attached to a hypoxia-localizing moiety comnprisinga metal, preferably radionuclide of rhenium or technetium;a hypoxia-localizing moiety; and,a complexing ligand, wherein said ligand and said radionuclide combined have cell membrane permeabilities greater than that of sucrose, are disclosed.
    Type: Grant
    Filed: April 3, 1995
    Date of Patent: September 15, 1998
    Assignee: Bracco International B.V.
    Inventors: Karen Linder, Adrian D. Nunn, David P. Nowotnik, Kondareddiar Ramalingam, Richard J. DiRocco, William L. Rumsey, John P. Pirro
  • Polymers and copolymers of acrylic acid MRI of the digestive tract of patients
    Patent number: 5792445
    Abstract: Suspensions of either echogenic or magnetic particles in aqueous bioadhesive carriers effectively improve imaging by echography, respectively NMRI, of the digestive tract. Affinity of the compositions for the gastric mucosa can be adapted to the needs by appropriately selecting the carrier in function to inherent bioadhesive capacity: this technique leads to improved visualization of selected portions of the lumen.
    Type: Grant
    Filed: February 7, 1996
    Date of Patent: August 11, 1998
    Assignee: Bracco International B.V.
    Inventors: Herve Tournier, Roland Hyacinthe, Friedrich Cavagna
  • Methods for preparing heteroatom-bearing ligands and metal complexes thereof
    Patent number: 5741912
    Abstract: Novel compounds containing a heteroatom-bearing bridge and novel complexes of these compounds with metals. The novel compounds and complexes are useful in diagnostic and therapeutic methods.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 21, 1998
    Assignee: Bracco International B.V.
    Inventors: Kondareddiar Ramalingam, Natarajan Raju
  • Method of making polymeric gas or air filled microballoons for ultrasonic echography
    Patent number: 5711933
    Abstract: Method of making gas or air filled microballoons having a mean size in the range of 0.5 to 1000 microns bounded by a 50 to 500 nm thick biodegradable, interfacially deposited, synthetic polymer membrane which is deformable and resilient for use in ultrasonic contrast compositions are described.
    Type: Grant
    Filed: August 10, 1994
    Date of Patent: January 27, 1998
    Assignee: Bracco International B.V.
    Inventors: Daniel Bichon, Philippe Bussat, Michel Schneider
  • Process for the crystallization from water of (S)-N,N'-bis?2-hydroxy-1-(hydroxymethyl)ethyl!-5-?2-hydroxy-1-oxopropyl) amino!-2,4,6-triiodo-1,3-benzendicarboxamide
    Patent number: 5689002
    Abstract: This invention refers to a process for the crystallization from water of S-N,N'-bis?2-hydroxy-1(hydroxymethyl)ethyl!-5-?(2-hydroxy-1-oxopropyl)amin o!-2,4,6-triiodo-1,3-benzendicarboxamide known as Iopamidol.According to the process of this invention, a crystalline anhydrous Iopamidol in accordance with pharmacopeia standards can be obtained.
    Type: Grant
    Filed: September 5, 1996
    Date of Patent: November 18, 1997
    Assignee: Bracco International B.V.
    Inventor: Marina Mauro
  • Diagnostic imaging methods using rhenium and technetium complexes containing a hypoxia-localizing moiety
    Patent number: 5688487
    Abstract: Novel methods, processes and metal complexes attached to a hypoxia-localizing moiety comprisinga metal, preferably radionuclide of rhenium or technetium;a hypoxia-localizing moiety; and,a complexing ligand, wherein said ligand and said radionuclide combined have cell membrane permeabilities greater than that of sucrose, are disclosed.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 18, 1997
    Assignee: Bracco International B.V.
    Inventors: Karen Linder, Adrian D. Nunn, David P. Nowotnik, Kondareddiar Ramalingam, Richard J. DiRocco, William L. Rumsey, John P. Pirro
  • Mucoadhesive compositions for increasing the ultrasonic image contrast of the digestive tract
    Patent number: 5688490
    Abstract: Suspensions of either echogenic or magnetic particles in aqueous bioadhesive carriers effectively improve imaging by echography, respectively NMRI, of the digestive tract. Affinity of the compositions for the gastric mucosa can be adapted to the needs by appropriately selecting the carrier in function to inherent bioadhesive capacity: this technique leads to improved visualization of selected portions of the lumen.
    Type: Grant
    Filed: February 7, 1996
    Date of Patent: November 18, 1997
    Assignee: Bracco International B.V.
    Inventors: Herve Tournier, Roland Hyacinthe, Friedrich Cavagna
  • Heteroatom-bearing ligands and metal complexes thereof
    Patent number: 5665329
    Abstract: Novel compounds containing a heteroatom-bearing bridge and novel complexes of these compounds with metals. The novel compounds and complexes are useful in diagnostic and therapeutic methods.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: September 9, 1997
    Assignee: Bracco International B.V.
    Inventors: Kondareddiar Ramalingam, Natarajan Raju
  • Hydrazone containing ligands and metal complexes thereof
    Patent number: 5663307
    Abstract: Novel compounds of the formula ##STR1## where G.sup.1 and G.sup.2 are each independently --OH or --N(R.sup.2).sub.2, provided that at least one of G.sup.1 and G.sup.2 is --N(R.sup.2).sub.2, where each R.sup.2 is independently hydrogen, alkyl, aryl, acyl or --(A).sub.p --R.sup.a and the other variables are as defined in the specification and claims, and novel complexes of these compounds with metals are useful in diagnostic and therapeutic methods.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: September 2, 1997
    Assignee: Bracco International B.V.
    Inventors: David P. Nowotnik, Palaniappa Nanjappan
  • Stable microbubbles suspensions injectable into living organisms
    Patent number: 5658551
    Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: August 19, 1997
    Assignee: Bracco International B.V.
    Inventors: Michel Schneider, Daniel Bichon, Philippe Bussat, Jerome Puginier, Eva Hybl-Sutherland
  • Process for the purifying of iopamidol
    Patent number: RE36433
    Abstract: A process for purifying Iopamidol which uses a butanol as solvent is described. Iopamidol is obtained with high yields, also starting from aqueous solutions of the same and has characteristics in accordance with those required by pharmacopoeia.
    Type: Grant
    Filed: February 7, 1997
    Date of Patent: December 7, 1999
    Assignee: Bracco International B.V.
    Inventors: Marco Villa, Maurizio Paiocchi