Patents Assigned to Bracco Research S.A.
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Publication number: 20120265065Abstract: A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.Type: ApplicationFiled: May 9, 2012Publication date: October 18, 2012Applicant: BRACCO RESEARCH S.A.Inventors: Michel Schneider, Christophe Golay, Laurent Jakob, Jean Brochot, Feng Yan, Christian Mathieu
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Publication number: 20120093731Abstract: Gas-filled microvesicles comprising a boundary envelope containing a gas, wherein said microvesicles comprise: —a first component, bound to said envelope, having binding affinity for an Fc-region of an antibody; and—a second component comprising a Fc-region of an antibody, bound to said first component through said Fc-region, said second component comprising a targeting ligand or a therapeutic agent. Aqueous suspensions of said microvesicles are particularly useful in contrast enhanced ultrasound imaging.Type: ApplicationFiled: December 19, 2007Publication date: April 19, 2012Applicant: Bracco Research S.A.Inventors: Eric Allemann, Thierry Bettinger, Philippe Bussat
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Publication number: 20110245663Abstract: A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.Type: ApplicationFiled: January 20, 2011Publication date: October 6, 2011Applicant: BRACCO RESEARCH S.A.Inventors: Michel Schneider, Christophe Golay, Laurent Jakob, Jean Brochot, Feng Yan, Christian Mathieu
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Publication number: 20110208115Abstract: Composition comprising gas filled microcapsules and a bioactive agent, useful for an ultrasound-mediated delivery of said bioactive agent. The microcapsules comprise a relatively stiff shell of polymeric or lipid material and have in particular a resistance to a mechanical index of at least 0.15, while the bioactive agent is substantially unbound to the shell of the microcapsules. The composition of the invention is particularly suitable for effectively delivering a genetic material into a cell, upon exposure of the composition to a level of acoustic pressure capable of destroying a portion of the microcapsules and releasing the gas contained therein.Type: ApplicationFiled: April 28, 2011Publication date: August 25, 2011Applicant: BRACCO RESEARCH S.A.Inventors: Thierry BETTINGER, Feng YAN, Sophie MEHIER-HUMBERT, Peter FRINKING
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Publication number: 20110200530Abstract: Pharmaceutical kit comprising (i) a targeting construct which comprises a targeting ligand and an anti-polymer antibody and (ii) a polymer-containing liposome or gas-filled microvesicle capable of binding or associating to said construct. Also disclosed are methods of preparing and of administering said assembly, as well as an assembly comprising said targeting construct and said liposome or gas-filled microvesicle.Type: ApplicationFiled: October 7, 2009Publication date: August 18, 2011Applicant: Bracco Research S.A. or Bracco Suisse S.A.Inventors: Eric Allemann, Thierry Bettinger, Philippe Bussat, Mathieu Hauwel, Feng Yan
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Publication number: 20110150778Abstract: Assembly comprising a gas-filled microvesicle and a structural entity which is capable to associate through an electrostatic interaction to the outer surface of said microvesicle (microvesicle associated component—MAC), thereby modifying the physico-chemical properties thereof. Said MAC comprises a targeting ligand a diagnostic agent or any combination thereof. Optionally a bioactive agent can further be associated to the MAC. The assembly of the invention can be formed from gas-filled microbubbles or microballoons and a MAC having preferably nanometric dimensions, e.g. a micelle, and is used as an active component in diagnostically and/or therapeutically active formulations, in particular for enhancing the imaging in the field of ultrasound contrast imaging, including targeted ultrasound imaging, ultrasound-mediated drug delivery and other imaging techniques such as molecular resonance imaging (MRI) or nuclear imaging.Type: ApplicationFiled: January 31, 2011Publication date: June 23, 2011Applicant: BRACCO RESEARCH S.A.Inventors: Michel Schneider, Philippe Bussat, Feng Yan, Anne Senente
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Patent number: 7749485Abstract: Composition for diagnostic or therapeutic use which comprises an assembly comprising an active agent. The assembly comprises a liposome and a plurality of micellar components associated thereto, said micellar components being associated to the outer surface of the envelope of said liposome through a substantially electrostatic interaction, When an active compound is incorporated into the micelles, a substantial amount of said active compound can be linked to a singe liposome. Furthermore, the presence of the outer micellar layer allows to increase the residence time of said liposome in the blood stream.Type: GrantFiled: May 31, 2005Date of Patent: July 6, 2010Assignee: Bracco Research S.A.Inventors: Herve Tournier, Roland Hyacinthe, Michel Schneider
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Publication number: 20100086490Abstract: Gas-filled microvesicles comprising a boundary envelope containing a gas, wherein said microvesicles comprise: —a first component, bound to said envelope, having binding affinity for an Fc-region of an antibody; and—a second component comprising a Fc-region of an antibody, bound to said first component through said Fc-region, said second component comprising a targeting ligand or a therapeutic agent. Aqueous suspensions of said microvesicles are particularly useful in contrast enhanced ultrasound imaging.Type: ApplicationFiled: December 19, 2007Publication date: April 8, 2010Applicant: Bracco Research S.A.Inventors: Eric Allemann, Thierry Bettinger, Philippe Bussat
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Publication number: 20090159485Abstract: A kit comprising a medical dispensing container (402), such as a vial for diagnostic agents, and a liquid transfer device (401) to be used to transfer a liquid into or from said dispensing container. The transfer device allows substantially limiting the gaseous exchange between the inside of a vial and the external ambient, when the device is connected to the vial in steady state conditions.Type: ApplicationFiled: December 5, 2006Publication date: June 25, 2009Applicant: Bracco Research S.A.Inventors: Laurent Jakob, Frederic Rivas
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Patent number: 7534239Abstract: A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.Type: GrantFiled: May 22, 2000Date of Patent: May 19, 2009Assignee: Bracco Research S.A.Inventors: Michel Schneider, Laurent Jakob, Christophe Golay, Jean Brochot, Feng Yan
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Publication number: 20090041833Abstract: Composition comprising gas filled microcapsules and a bioactive agent, useful for an ultrasound-mediated delivery of said bioactive agent. The microcapsules comprise a relatively stiff shell of polymeric or lipid material and have in particular a resistance to a mechanical index of at least 0.15, while the bioactive agent is substantially unbound to the shell of the microcapsules. The composition of the invention is particularly suitable for effectively delivering a genetic material into a cell, upon exposure of the composition to a level of acoustic pressure capable of destroying a portion of the microcapsules and releasing the gas contained therein.Type: ApplicationFiled: April 11, 2006Publication date: February 12, 2009Applicant: Bracco Research S.A.Inventors: Thierry Bettinger, Feng Yan, Sophie Mehier-Humbert, Peter Frinking
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Publication number: 20090017475Abstract: Method and kit for determining the possible appearance of adverse reactions (such as anaphylactoid reactions) in patients in need to undergo to an administration of a pharmaceutical compound. The method for determining potential hypersensitivity in a patient to pseudo-allergic reactions comprises adding a predetermined amount of a compound with anaphylatoxic activity to a sample of the patient's blood and determining the amount of activation of the patient's basophil cells in said blood sample. The compound with anaphylatoxic activity is preferably selected from C3a, C5a, analogs of C3a or C5a, derivatives of C3a or C5a, and mixtures thereof.Type: ApplicationFiled: February 5, 2007Publication date: January 15, 2009Applicant: Bracco Research S.A.Inventor: Xavier Fouillet
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Publication number: 20080045919Abstract: Liquid transfer device to be used to transfer a liquid into or from a dispensing container, particularly a medical dispensing container like a vial for diagnostic agents and kit comprising a vial, a syringe and a device of the aforementioned type. The transfer device comprises a valve which substantially limits the gaseous exchange between the inside of a vial and the external ambient, when the device is connected to the vial in steady state conditions.Type: ApplicationFiled: December 20, 2005Publication date: February 21, 2008Applicant: Bracco Research S.A.Inventors: Laurent Jakob, Frederic Rivas
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Publication number: 20080008657Abstract: The present invention relates to a new composition comprising gas-filled microvesicles for contrast imaging which are particularly suitable for providing an effective echo response to at least two selected ultrasound waves having different frequencies. Said composition preferably comprises at least two different preparations of gas-filled microvesicles, which preferably have respective different mean sizes. In particular, said preparations preferably have respective Dv values differing from each other by at least 0.5 ?m, more preferably at least 1.0 ?m. Alternatively, said composition has a volume size distribution showing a value of Bowley skewness of 0.16 or higher. According to a preferred embodiment, at least 95% of the total volume of gas contained in said microvesicles, calculated on the population of microvesicles up to a diameter of 10 ?m, is contained in microvesicles having a diameter of 8 micron or less.Type: ApplicationFiled: August 17, 2005Publication date: January 10, 2008Applicant: Bracco Research S.A.Inventors: Philippe Bussat, Peter Frinking, Christian Guillot, Michel Schneider
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Publication number: 20070196284Abstract: Composition for diagnostic or therapeutic use which comprises an assembly comprising an active agent. The assembly comprises a liposome and a plurality of micellar components associated thereto, said micellar components being associated to the outer surface of the envelope of said liposome through a substantially electrostatic interaction. When an active compound is incorporated into the micelles, a substantial amount of said active compound can be linked to a singe liposome. Furthermore, the presence of the outer micellar layer allows to increase the residence time of said liposome in the blood stream.Type: ApplicationFiled: May 31, 2005Publication date: August 23, 2007Applicant: Bracco Research S.A.Inventors: Herve Tournier, Roland Hyacinthe, Michel Schneider
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Publication number: 20070081946Abstract: Assembly comprising a gas-filled microvesicle and a structural entity which is capable to associate through an electrostatic interaction to the outer surface of said microvesicle (microvesicle associated component—MAC), thereby modifying the physico-chemical properties thereof. Said MAC comprises a targeting ligand a diagnostic agent or any combination thereof. Optionally a bioactive agent can further be associated to the MAC. The assembly of the invention can be formed from gas-filled microbubbles or microballoons and a MAC having preferably nanometric dimensions, e.g. a micelle, and is used as an active component in diagnostically and/or therapeutically active formulations, in particular for enhancing the imaging in the field of ultrasound contrast imaging, including targeted ultrasound imaging, ultrasound-mediated drug delivery and and other imaging techniques such as molecular resonance imaging (MRI) or nuclear imaging.Type: ApplicationFiled: December 21, 2004Publication date: April 12, 2007Applicant: Bracco Research S.A.Inventors: Michel Schneider, Philippe Bussat, Feng Yan, Anne Senente
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Publication number: 20070071685Abstract: Assembly comprising a gas-filled microvesicle and a structural entity which is capable to associate through an electrostatic interaction to the outer surface of said microvesicle (microvesicle associated component—MAC), thereby modifying the physico-chemical properties thereof. Said MAC may optionally comprise a targeting ligand, a bioactive agent, a diagnostic agent or any combination thereof. The assembly of the invention can be formed from gasfilled microbubbles or microballoons and a MAC having a diameter of less than 100 pm, in particular a micelle and is used as an active component in diagnostically and/or therapeutically active formulations, in particular for enhancing the imaging in the field of ultrasound contrast imaging, including targeted ultrasound imaging, ultrasound-mediated drug delivery and other imaging techniques such as molecular resonance imaging (MRI) or nuclear imaging.Type: ApplicationFiled: December 21, 2004Publication date: March 29, 2007Applicant: Bracco Research S.A.Inventors: Michel Schneider, Philippe Bussat, Feng Yan, Anne Senente
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Patent number: 6962071Abstract: The present invention relates to remotely determining local physical parameters in a fluid-filled cavity (e.g. heart cavities, blood vessels, industrial container) by means of ultrasound waves and encapsulated or stabilised gas bubbles. A measuring method, a method of diagnostic ultrasound of the same and an apparatus for remotely determining ambient physical local parameters of a fluid-filled cavity are disclosed.Type: GrantFiled: April 5, 2002Date of Patent: November 8, 2005Assignee: Bracco Research S.A.Inventors: Peter J. A. Frinking, Marcel Arditi
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Publication number: 20040197269Abstract: The invention relates to injectable media for ultrasonic echography in the form of microbubbles or microballoons comprising at least two biocompatible substances A and B (gaseous at the body temperature) forming a mixture which when in suspension with usual surfactants, additives and stabilisers provides useful ultrasound contrast agents. At least one of the components (B) in the mixture is a gas whose molecular weight is greater than 80 daltons and whose solubility in water is below 0.0283 ml per ml of water at standard conditions. The presence of the first component (B) in the contrast medium may vary between 0.5 and 41 volume percent. The other component (A) of the ultrasound contrast media is a gas or a mixture of gases whose molecular weight is below 80 daltons. The second component is present in a proportion of between 59-99.5% by vol., and is preferably chosen from oxygen, air, nitrogen, carbon dioxide or mixtures thereof.Type: ApplicationFiled: April 26, 2004Publication date: October 7, 2004Applicant: Bracco Research S.A.Inventors: Feng Yan, Michel Schneider, Jean Brochot
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Patent number: 6726650Abstract: A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.Type: GrantFiled: December 3, 1998Date of Patent: April 27, 2004Assignee: Bracco Research S.A.Inventors: Michel Schneider, Christophe Golay, Laurent Jakob, Jean Brochot, Feng Yan, Christian Mathieu