Patents Assigned to Bracco S.p.A.
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Patent number: 10238615Abstract: The invention regards the use of triiodothyronine sulfate, commonly named T3S, as a medicament having thyromimetic activity for the treatment of pathologies due to organic deficiency of triiodothyronine (T3), as such or in association with thyroxine (T4), and pharmaceutical formulations for oral administration thereof.Type: GrantFiled: September 21, 2016Date of Patent: March 26, 2019Assignee: Bracco S.P.A.Inventors: Livio Cavalieri, Giovanni Rivolta, Fulvia Vella
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Publication number: 20170007563Abstract: The invention regards the use of triiodothyronine sulfate, commonly named T3S, as a medicament having thyromimetic activity for the treatment of pathologies due to organic deficiency of triiodothyronine (T3), as such or in association with thyroxine (T4), and pharmaceutical formulations for oral administration thereof.Type: ApplicationFiled: September 21, 2016Publication date: January 12, 2017Applicant: Bracco S.P.A.Inventors: Livio Cavalieri, Giovanni Rivolta, Fulvia Vella
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Patent number: 9468619Abstract: The invention regards the use of triiodothyronine sulfate, commonly named T3S, as a medicament having thyromimetic activity for the treatment of pathologies due to organic deficiency of triiodothyronine (T3), as such or in association with thyroxine (T4), and pharmaceutical formulations for oral administration thereof.Type: GrantFiled: June 13, 2013Date of Patent: October 18, 2016Assignee: Bracco S.P.A.Inventors: Aldo Pinchera, Livio Cavalieri, Federico Maisano, Giovanni Rivolta, Ferruccio Santini, Fulvia Vella
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Patent number: 9439883Abstract: The invention regards the use of triiodothyronine sulfate, commonly named T3S, as a medicament having thyromimetic activity for the treatment of pathologies due to organic deficiency of triiodothyronine (T3), as such or in association with thyroxine (T4), and pharmaceutical formulations for oral administration thereof.Type: GrantFiled: June 13, 2013Date of Patent: September 13, 2016Assignee: Bracco S.P.A.Inventors: Aldo Pinchera, Livio Cavalieri, Federico Maisano, Giovanni Rivolta, Ferruccio Santini, Fulvia Vella
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Patent number: 9044441Abstract: The invention regards the use of triiodothyronine sulfate, commonly named T3S, as a medicament having thyromimetic activity for the treatment of pathologies due to organic deficiency of triiodothyronine (T3), as such or in association with thyroxine (T4), and pharmaceutical formulations for oral administration thereof.Type: GrantFiled: January 31, 2013Date of Patent: June 2, 2015Assignee: Bracco S.P.A.Inventor: Federico Maisano
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Publication number: 20130146502Abstract: The invention regards the use of triiodothyronine sulfate, commonly named T3S, as a medicament having thyromimetic activity for the treatment of pathologies due to organic deficiency of triiodothyronine (T3), as such or in association with thyroxine (T4), and pharmaceutical formulations for oral administration thereof.Type: ApplicationFiled: January 31, 2013Publication date: June 13, 2013Applicant: BRACCO S.P.A.Inventor: BRACCO S.P.A.
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Publication number: 20120087902Abstract: The involvement of intestinal microbiota in the initiation and perpetuation of inflammatory bowel disease is widely accepted. To reestablish the homeostasis of the gut the use of probiotics has been proposed, with however, limited clinical benefit. This invention relates to an assay based on the modulation of the immunological activity in DCs (dendritic cells) by probiotic strains, in particular L. paracasei and their use in protecting against inflammatory bowel and liver diseases.Type: ApplicationFiled: July 20, 2010Publication date: April 12, 2012Applicant: BRACCO S.P.A.Inventors: Maria Rescigno, Carmelina Loguercio, Enzo Grossi
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Publication number: 20110245342Abstract: The invention regards the use of triiodothyronine sulfate, commonly named T3S, as a medicament having thyromimetic activity for the treatment of pathologies due to organic deficiency of triiodothyronine (T3), as such or in association with thyroxine (T4), and pharmaceutical formulations for oral administration thereof.Type: ApplicationFiled: April 8, 2011Publication date: October 6, 2011Applicant: Bracco S.p.A.Inventors: Aldo PINCHERA, Ferruccio Santini, Giovanni Rivolta, Livio Cavalieri, Fulvia Vella, Federico Maisano
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Patent number: 7807395Abstract: A method for the laboratory determination of prosthetic infections is described. This method, performed on biological fluids isolated from patients, is based on the detection of antibodies specific for the polysaccharides produced by bacteria colonizing prosthetic devices.Type: GrantFiled: May 1, 2002Date of Patent: October 5, 2010Assignee: BRACCO S.p.A.Inventors: Maria Cristina Thaller, Gianmaria Rossolini, Laura Selan, Claudio Passariello
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Patent number: 7214794Abstract: The present invention is directed to ceramide analog compounds of general formula (I) the process for their preparation and use for the preparation of pharmaceutical formulations for the treatment of tumorsType: GrantFiled: August 17, 2004Date of Patent: May 8, 2007Assignee: Bracco S.p.A.Inventors: Bruno Macchia, Aldo Balsamo, Marco Macchia, Mario Del Tacca, Romano Danesi
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Publication number: 20050272816Abstract: The invention regards the use of triiodothyronine sulfate, commonly named T3S, as a medicament having thyromimetic activity for the treatment of pathologies due to organic deficiency of triiodothyronine (T3), as such or in association with thyroxine (T4), and pharmaceutical formulations thereof.Type: ApplicationFiled: November 11, 2003Publication date: December 8, 2005Applicant: Bracco S.p.A.Inventors: Aldo Pinchera, Ferruccio Santini
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Patent number: 6956109Abstract: The present invention is directed to ceramide analog compounds of general formula (I) the process for their preparation and use for the preparation of pharmaceutical formulations for the treatment of tumors.Type: GrantFiled: July 21, 2000Date of Patent: October 18, 2005Assignee: Bracco S.p.A.Inventors: Bruno Macchia, Aldo Balsamo, Marco Macchia, Mario Del Tacca, Romano Danesi
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Patent number: 6509324Abstract: Compounds able to chelate bi- and trivalent paramagnetic metal ions, their chelated complexes with these metal ions and physiologically compatible salts thereof and therein magnetic resonance imaging.Type: GrantFiled: September 24, 2001Date of Patent: January 21, 2003Assignee: Bracco S.p.A.Inventors: Maurizio Franzini, Andrea Beltrami, Luisella Calabi, Alessandro Maiocchi, Mario Virtuani, Pier Lucio Anelli, Kondareddiar Ramalingam, Ramachandran S. Ranganathan
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Publication number: 20020197280Abstract: A method for the laboratory determination of prosthetic infections is described. This method, performed on biological fluids isolated from patients, is based on the detection of antibodies specific for the polysaccharides produced by bacteria colonizing prosthetic devices.Type: ApplicationFiled: May 1, 2002Publication date: December 26, 2002Applicant: Bracco S.p.A.Inventors: Maria Cristina Thaller, Gianmaria Rossolini, Laura Selan, Claudio Passariello
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Patent number: 6321105Abstract: A method for Magnetic Resonance Imaging (MRI) of changes in neurotransmitter and neuroreceptor activity as a metabolic response to diagnostic challenge or therapeutic treatment in a patient with suspected or already diagnosed mental illnesses of psychiatric, neurodegnerative or neurological nature, by (a) administering to a patient a drug eliciting an MRI detectable hemodynamic response; (b) administering to the patient an MRI contrast agent with high magnetic susceptibility, and then (c) measuring, in a spatially and temporally resolved manner, relative Cerebral Blood Volume (rCBV) changes associated to neuronal activation using T2- or T2*-weighted MRI scans at the equilibrium distribution of said contrast agent.Type: GrantFiled: April 7, 1999Date of Patent: November 20, 2001Assignee: Bracco S.p.A.Inventors: Bruce G. Jenkins, Joe B. Mandeville, Friedrich M. Cavagna
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Patent number: 5626832Abstract: Injectable aqueous composition intended for opacifying certain organs with a view to examination by X-rays. This composition is based on liposomes containing, encapsulated thereein, an aqueous solution of an iodinated opacifying agent. The ratio between the weight of iodine encapsulated by the liposomes and the weight of the lipids from which their membrane is formed is not lower than 1.5 mg/mg.Type: GrantFiled: May 12, 1995Date of Patent: May 6, 1997Assignee: Bracco S.p.A.Inventors: Michel Schneider, Herv e Tournier, Bernard Lamy
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Patent number: 5599931Abstract: The (6S) stereoisomer of folinic acid is obtained in high optical purity by salification of (R,S) folinic acid with di- or polyamines and subsequent selective crystallization of the desired diasteromeric salt.Type: GrantFiled: June 1, 1995Date of Patent: February 4, 1997Assignee: Bracco S.p.A.Inventors: Giorgio Ripa, Rodolfo Piva, Ernst Fekder
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Patent number: 5380281Abstract: The device comprises a tubular housing with two jackets and a container filled with the liquid component of a drug. Within the inner jacket of the housing, close to the closed end thereof, is a chamber containing the powdered components of a drug. A needle for piercing the stopper which closes the container enables the interior of the container to be put in communication with the chamber so as to allow the liquid component to flow out and consequently mix with the powdered component. The subsequent advance of the container into the housing, with the consequent penetration of the piston into the container, causes the further flow of the liquid component into the chamber carrying the drug solution to the exterior of the device generally like a syringe. Its use as a supplier of infusions is also foreseen.Type: GrantFiled: January 13, 1994Date of Patent: January 10, 1995Assignee: BRACCO, S.p.A.Inventors: Giorgio Tomellini, Gian A. Rollandi
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Patent number: 5368839Abstract: Diagnostic compositions particularly useful for NMR imaging of the gastrointestinal tract, comprise physiologically acceptable aqueous suspensions of insoluble salts of lanthanides, buffered, if required, at a pH value between 6.0 and 8.5 and which are, if required, formulated with appropriate insoluble organic or inorganic additives and/or with dispersing agents, suspending agents or viscosity-enhancing agents. These compositions are capable of increasing the value of the r.sub.2 /r.sub.1 ratio, in which r.sub.1 and r.sub.2 are the longitudinal and transversal relaxivities of the protons of the surrounding water, thus permittting the production of clear images which have negative contrast and which lack artefacts of metallic type.Type: GrantFiled: November 6, 1992Date of Patent: November 29, 1994Assignee: Bracco S.p.A.Inventors: Silvio Aime, Mauro Botta