Patents Assigned to Bracco, Suisse SA
-
Publication number: 20140163366Abstract: A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.Type: ApplicationFiled: December 12, 2013Publication date: June 12, 2014Applicant: BRACCO SUISSE SAInventors: Michel SCHNEIDER, Christophe GOLAY, Laurent JAKOB, Jean BROCHOT, Feng YAN, Christian MATHIEU
-
Patent number: 8663603Abstract: The invention provides compositions and methods for therapeutic and diagnostic applications.Type: GrantFiled: September 23, 2010Date of Patent: March 4, 2014Assignees: Bracco Suisse SA, Dyax Corp.Inventors: Christophe Arbogast, Philippe Bussat, Hong Fan, Karen E. Linder, Edmund R. Marinelli, Palaniappa Nanjappan, Adrian D. Nunn, Radhakrishna K. Pillai, Sibylle Pochon, Kondareddiar Ramalingam, Ajay Shrivastava, Bo Song, Rolf E. Swenson, Mathew A. Von Wronski, Feng Yan, Aaron K. Sato, Sharon Michele Walker, Daniel T. Dransfield
-
Patent number: 8642010Abstract: The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD<1 ?M), and dimer and multimeric constructs comprising these polypeptides.Type: GrantFiled: June 8, 2009Date of Patent: February 4, 2014Assignees: Dyax Corp., Bracco Suisse SAInventors: Aaron K. Sato, Daniel J. Sexton, Daniel T. Dransfield, Robert C. Ladner, Christophe Arbogast, Philippe Bussat, Hong Fan, Sudha Khurana, Karen E. Linder, Edmund R. Marinelli, Palaniappa Nanjappan, Adrian D. Nunn, Radhakrishna K. Pillai, Sibylle Pochon, Feng Yan, Kondareddiar Ramalingam, Ajay Shrivastava, Bo Song, Rolf E. Swenson, Mathew A. Von Wronski
-
Publication number: 20140031520Abstract: Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.Type: ApplicationFiled: July 23, 2013Publication date: January 30, 2014Applicant: Bracco Suisse SAInventors: Philippe BUSSAT, Samir Cherkaoui, Hong (Helen) Fan, Bernard Lamy, Palaniappa Nanjappan, Radhakrishna K. Pillai, Sibylle Pochon, Bo Song, Rolf E. Swenson
-
Patent number: 8632753Abstract: The invention provides compositions and methods for therapeutic and diagnostic applications.Type: GrantFiled: December 20, 2010Date of Patent: January 21, 2014Assignees: Bracco Suisse SA, Dyax Corp.Inventors: Hong Fan, Karen E. Linder, Edmund R. Marinelli, Palaniappa Nanjappan, Adrian D. Nunn, Radhakrishna K. Pillai, Kondareddiar Ramalingam, Ajay Shrivastava, Bo Song, Rolf E. Swenson, Mathew A. Von Wronski, Aaron K. Sato, Sharon Michele Walker, Daniel T. Dransfield
-
Patent number: 8623822Abstract: The present invention provides polypeptides, peptide dimers, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD<1 ?M), and dimer and multimeric constructs comprising these polypeptides, particularly contrast agents. Also provided are methods for monitoring and evaluating the therapeutic effectiveness of treatment protocols for diseases associated with angiogenesis or endothelial cell hyperproliferation, such as cancer, using contrast agents of the invention.Type: GrantFiled: October 5, 2010Date of Patent: January 7, 2014Assignee: Bracco Suisse SAInventors: Christophe Arbogast, Philippe Bussat, Hong Fan, Sudha Khurana, Karen E. Linder, Edmund R. Marinelli, Palaniappa Nanjappan, Adrian D. Nunn, Radhakrishna K. Pillai, Sibylle Pochon, Kondareddiar Ramalingam, Ajay Shrivastava, Bo Song, Rolf E. Swenson, Mathew A. Von Wronski, Feng Yan
-
Publication number: 20130060135Abstract: An embodiment includes analyzing a body part perfused with a contrast agent, which has been pre-administered as a bolus to circulate through the body-part with at least a first passage during an analysis interval. The analyzing includes providing at least one input signal indicative of a response to an interrogation signal of a corresponding location of the body part during the analysis interval, and fitting each input signal over the analysis interval by an instance of a combined bolus function of time, based on a combination of a first simple bolus function of time modeling the first passage of the contrast agent and at least one second simple bolus function of time each one modeling a corresponding second passage of the contrast agent.Type: ApplicationFiled: September 7, 2012Publication date: March 7, 2013Applicant: BRACCO SUISSE SAInventors: Peter FRINKING, Nicolas ROGNIN, Marcel ARDITI
-
Patent number: 8263739Abstract: The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use. Additionally, the present invention includes diagnostic, therapeutic and radiotherapeutic compositions useful for visualization, therapy or radiotherapy.Type: GrantFiled: January 27, 2006Date of Patent: September 11, 2012Assignee: Bracco Suisse SAInventors: Mathew A. Von Wronski, Edmund R. Marinelli, Adrian Nunn, Radhakrishna Pillai, Kondareddiar Ramalingam, Michael F. Tweedle, Karen E. Linder, Palaniappa Nanjappan, Natarajan Raju
-
Publication number: 20110311446Abstract: A polypeptide or multimeric polypeptide construct having the ability to bind to cMet or a complex comprising cMet and HGF, and methods for use are disclosed.Type: ApplicationFiled: July 14, 2011Publication date: December 22, 2011Applicants: Bracco Suisse SA, Dyax Corp.Inventors: Daniel T. Dransfield, Aaron Sato, Robert Charles Ladner, Palaniappa Nanjappan
-
Patent number: 8044175Abstract: A polypeptide or multimeric polypeptide construct having the ability to bind to cMet or a complex comprising cMet and HGF, and methods for use are disclosed.Type: GrantFiled: January 30, 2008Date of Patent: October 25, 2011Assignees: Dyax Corp., Bracco Suisse SAInventors: Daniel T. Dransfield, Aaron Sato, Robert Charles Ladner, Palaniappa Nanjappan
-
Patent number: 7985402Abstract: Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.Type: GrantFiled: December 11, 2007Date of Patent: July 26, 2011Assignee: Bracco Suisse SAInventors: Philippe Bussat, Samir Cherkaoui, Hong (Helen) Fan, Bernard Lamy, Palaniappa Nanjappan, Radhakrishna K. Pillai, Sibylle Pochon, Bo Song, Rolf E. Swenson
-
Publication number: 20110097275Abstract: The present invention provides polypeptides, peptide dimers, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD<1 ?M), and dimer and multimeric constructs comprising these polypeptides, particularly contrast agents. Also provided are methods for monitoring and evaluating the therapeutic effectiveness of treatment protocols for diseases associated with angiogenesis or endothelial cell hyperproliferation, such as cancer, using contrast agents of the invention.Type: ApplicationFiled: October 5, 2010Publication date: April 28, 2011Applicant: BRACCO SUISSE SAInventors: Christophe Arbogast, Philippe Bussat, Hong Fan, Sudha Khurana, Karen E. Linder, Edmund R. Marinelli, Palaniappa Nanjappan, Adrian D. Nunn, Radhakrishna K. Pillai, Sibylle Pochon, Kondareddiar Ramalingam, Ajay Shrivastava, Bo Song, Rolf E. Swenson, Mathew A. Von Wronski, Feng Yan
-
Patent number: 7910088Abstract: The invention provides compositions and methods for therapeutic and diagnostic applications.Type: GrantFiled: March 21, 2007Date of Patent: March 22, 2011Assignees: Bracco Suisse SA, Dyax Corp.Inventors: Christophe Arbogast, Philippe Bussat, Hong Fan, Karen E. Linder, Edmund R. Marinelli, Palaniappa Nanjappan, Adrian D. Nunn, Radhakrishna K. Pillai, Sibylle Pochon, Kondareddiar Ramalingam, Ajay Shrivastava, Bo Song, Rolf E. Swenson, Mathew A. Von Wronski, Aaron K. Sato, Sharon Michele Walker, Daniel T. Dransfield, Feng Yan
-
Patent number: 7884183Abstract: The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use. Additionally, the present invention includes diagnostic, therapeutic and radiotherapeutic compositions useful for visualization, therapy or radiotherapy.Type: GrantFiled: May 5, 2006Date of Patent: February 8, 2011Assignee: Bracco Suisse SAInventors: Mathew A. Von Wronski, Edmund R. Marinelli, Adrian D. Nunn, Radhakrishna K. Pillai, Kondareddiar Ramalingam, Michael F. Tweedle, Karen E. Linder, Palaniappa Nanjappan, Natarajan Raju, Feng Yan, Michel Schneider
-
Publication number: 20110015522Abstract: An embodiment of a solution is proposed for analyzing a body part of a patient, which is perfused with a contrast agent capable of circulating within the patient and of being substantially immobilized on a biological target. An embodiment of a corresponding system includes means for providing an echo signal indicative of a response over time to an interrogation signal of the body part, means for associating the echo signal with a model function of time modeling an evolution over time of the contrast agent in the body part, the model function including a combination of a circulation function modeling the circulation of the contrast agent and a decay function modeling a decay of the echo signal from the immobilized contrast agent, and means for estimating at least one kinetics indicator of the contrast agent from the model function.Type: ApplicationFiled: December 23, 2008Publication date: January 20, 2011Applicant: BRACCO SUISSE SAInventors: Marcel Arditi, Tristan Messager, Michel Schneider, Peter Frinking
-
Patent number: 7854919Abstract: The invention provides compositions and methods for therapeutic and diagnostic applications.Type: GrantFiled: January 19, 2007Date of Patent: December 21, 2010Assignees: Bracco, Suisse SA, Dyax CorporationInventors: Christophe Arbogast, Philippe Bussat, Hong Fan, Karen E. Linder, Edmund R. Marinelli, Palaniappa Nanjappan, Adrian Nunn, Radhakrishna Pillai, Sibylle Pochon, Kondareddiar Ramalingam, Bo Song, Rolf E. Swenson, Mathew A. Von Wronski, Aaron Sato, Sharon Michele Walker, Daniel T. Dransfield, Ajay Shrivastava