Patents Assigned to BRAINBOX SOLUTIONS, INC.
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Publication number: 20260219284Abstract: Methods, compositions and kits useful in the detection, assessment, diagnosis, prognosis and/or treatment of brain injuries, especially mild traumatic brain injury (mTBI) or concussion, are based upon detection of changes in levels of certain protein biomarkers in a subject undergoing testing, or upon detection of changes in levels of certain protein biomarkers in conjunction with neuroimaging analyses to detect changes in vascular or blood brain barrier (BBB) permeability in the brain, or to detect damage to fiber tracts in the brain, in which changes in biomarker levels correlate with detection of changes in BBB permeability or in brain fiber tract or white matter damage in a subject with brain injury such as mTBI or concussion.Type: ApplicationFiled: October 9, 2025Publication date: July 30, 2026Applicant: BRAINBOX SOLUTIONS, INC.Inventors: Timothy E. VAN METER, Nazanin MIRSHAHI
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Publication number: 20260063646Abstract: Methods, compositions and kits useful in the diagnosis, prognosis and/or assessment of brain injuries and risk for brain injuries, such as hemorrhage, are based upon detection of certain biomarkers.Type: ApplicationFiled: March 14, 2025Publication date: March 5, 2026Applicant: BRAINBOX SOLUTIONS, INC.Inventors: Donna J. EDMONDS, Timothy E. VAN METER, NaZanin MIRSHAHI
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Patent number: 12560619Abstract: Methods and compositions for diagnosing brain injury, neurodegeneration; or a predisposition thereto, in a subject are provided. Particularly, the present invention relates to specific antigen antibody reactivities useful in diagnosing brain injury, neurodegeneration or a predisposition thereto, in a subject.Type: GrantFiled: June 5, 2024Date of Patent: February 24, 2026Assignee: BRAINBOX SOLUTIONS, INC.Inventors: Rachel Sorek, Keren Jakobi, Donna Edmonds
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Patent number: 12461112Abstract: Methods, compositions and kits useful in the detection, assessment, diagnosis, prognosis and/or treatment of brain injuries, especially mild traumatic brain injury (mTBI) or concussion, are based upon detection of changes in levels of certain protein biomarkers in a subject undergoing testing, or upon detection of changes in levels of certain protein biomarkers in conjunction with neuroimaging analyses to detect changes in vascular or blood brain barrier (BBB) permeability in the brain, or to detect damage to fiber tracts in the brain, in which changes in biomarker levels correlate with detection of changes in BBB permeability or in brain fiber tract or white matter damage in a subject with brain injury such as mTBI or concussion.Type: GrantFiled: June 6, 2023Date of Patent: November 4, 2025Assignee: Brainbox Solutions, Inc.Inventors: Timothy E. Van Meter, Nazanin Mirshahi
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Patent number: 12265091Abstract: Methods, compositions and kits useful in the diagnosis, prognosis and/or assessment of brain injuries and risk for brain injuries, such as hemorrhage, are based upon detection of certain biomarkers.Type: GrantFiled: October 8, 2021Date of Patent: April 1, 2025Assignee: BRAINBOX SOLUTIONS, INC.Inventors: Donna J. Edmonds, Timothy E. Van Meter, NaZanin Mirshahi
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Publication number: 20250067754Abstract: Methods and compositions for diagnosing brain injury, neurodegeneration; or a predisposition thereto, in a subject are provided. Particularly, the present invention relates to specific antigen antibody reactivities useful in diagnosing brain injury, neurodegeneration or a predisposition thereto, in a subject.Type: ApplicationFiled: June 5, 2024Publication date: February 27, 2025Applicant: BRAINBOX SOLUTIONS, INC.Inventors: RACHEL SOREK, KEREN JAKOBI, DONNA EDMONDS
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Publication number: 20250044303Abstract: Methods, compositions and kits useful in the detection, assessment, diagnosis, prognosis and/or treatment of neurological injury or disease or brain injury, such as traumatic brain injury (TBI), are provided in which certain newly discovered protein biomarkers are detected in a biological sample of a subject undergoing testing or evaluation. The methods allow for detection of changes in levels, amounts, or concentrations of the protein biomarkers in a subject compared with those of controls. Detection of the protein biomarkers, and/or levels thereof, provides an indication of biological and biochemical events, e.g., at a cellular level, that are occurring in the subject who is undergoing testing or analysis for the neurological injury or brain injury.Type: ApplicationFiled: April 25, 2024Publication date: February 6, 2025Applicant: BRAINBOX SOLUTIONS, INC.Inventor: Timothy E. VAN METER
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Patent number: 12038446Abstract: Methods and compositions for diagnosing brain injury, neurodegeneration; or a predisposition thereto, in a subject are provided. Particularly, the present invention relates to specific antigen antibody reactivities useful in diagnosing brain injury, neurodegeneration or a predisposition thereto, in a subject.Type: GrantFiled: March 12, 2019Date of Patent: July 16, 2024Assignee: Brainbox Solutions, Inc.Inventors: Rachel Sorek, Keren Jakobi, Donna Edmonds
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Patent number: 11988676Abstract: Methods, compositions and kits useful in the detection, assessment, diagnosis, prognosis and/or treatment of neurological injury or disease or brain injury, such as traumatic brain injury (TBI), are provided in which certain newly discovered protein biomarkers are detected in a biological sample of a subject undergoing testing or evaluation. The methods allow for detection of changes in levels, amounts, or concentrations of the protein biomarkers in a subject compared with those of controls. Detection of the protein biomarkers, and/or levels thereof, provides an indication of biological and biochemical events, e.g., at a cellular level, that are occurring in the subject who is undergoing testing or analysis for the neurological injury or brain injury.Type: GrantFiled: November 15, 2018Date of Patent: May 21, 2024Assignee: BRAINBOX SOLUTIONS, INC.Inventor: Timothy E. Van Meter
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Publication number: 20230314453Abstract: Methods, compositions and kits useful in the detection, assessment, diagnosis, prognosis and/or treatment of brain injuries, especially mild traumatic brain injury (mTBI) or concussion, are based upon detection of changes in levels of certain protein biomarkers in a subject undergoing testing, or upon detection of changes in levels of certain protein biomarkers in conjunction with neuroimaging analyses to detect changes in vascular or blood brain barrier (BBB) permeability in the brain, or to detect damage to fiber tracts in the brain, in which changes in biomarker levels correlate with detection of changes in BBB permeability or in brain fiber tract or white matter damage in a subject with brain injury such as mTBI or concussion.Type: ApplicationFiled: June 6, 2023Publication date: October 5, 2023Applicant: Brainbox Solutions, Inc.Inventors: Timothy E. VAN METER, Nazanin Mirshahi
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Patent number: 11709168Abstract: Methods, compositions and kits useful in the detection, assessment, diagnosis, prognosis and/or treatment of brain injuries, especially mild traumatic brain injury (mTBI) or concussion, are based upon detection of changes in levels of certain protein biomarkers in a subject undergoing testing, or upon detection of changes in levels of certain protein biomarkers in conjunction with neuroimaging analyses to detect changes in vascular or blood brain barrier (BBB) permeability in the brain, or to detect damage to fiber tracts in the brain, in which changes in biomarker levels correlate with detection of changes in BBB permeability or in brain fiber tract or white matter damage in a subject with brain injury such as mTBI or concussion.Type: GrantFiled: May 22, 2018Date of Patent: July 25, 2023Assignee: BRAINBOX SOLUTIONS, INC.Inventors: Timothy E. Van Meter, Nazanin Mirshahi
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Publication number: 20220026448Abstract: Methods, compositions and kits useful in the diagnosis, prognosis and/or assessment of brain injuries and risk for brain injuries, such as hemorrhage, are based upon detection of certain biomarkers.Type: ApplicationFiled: October 8, 2021Publication date: January 27, 2022Applicant: BRAINBOX SOLUTIONS, INC.Inventors: Donna J. EDMONDS, Timothy E. VAN METER, NaZanin MIRSHAHI
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Patent number: 11143662Abstract: Methods, compositions and kits useful in the diagnosis, prognosis and/or assessment of brain injuries and risk for brain injuries, such as hemorrhage, are based upon detection of certain biomarkers.Type: GrantFiled: June 29, 2017Date of Patent: October 12, 2021Assignee: BRAINBOX SOLUTIONS, INC.Inventors: Donna J. Edmonds, Timothy E. Van Meter, NaZanin Mirshahi
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Publication number: 20190195893Abstract: Methods and compositions for diagnosing brain injury, neurodegeneration; or a predisposition thereto, in a subject are provided. Particularly, the present invention relates to specific antigen antibody reactivities useful in diagnosing brain injury, neurodegeneration or a predisposition thereto, in a subject.Type: ApplicationFiled: March 12, 2019Publication date: June 27, 2019Applicant: BRAINBOX SOLUTIONS, INC.Inventors: RACHEL SOREK, KEREN JAKOBI, DONNA EDMONDS