Patents Assigned to Braintree Laboratories, Inc.
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Patent number: 12290529Abstract: Disclosed herein are methods of administering compositions comprising a mixture of salts that induce purgation of the colon and are useful to cleanse the colon. Furthermore, the disclosed methods prevent degradation of PEG and allow for cleansing of the colon without the use of adjunct laxatives, including stimulant laxatives such as bisacodyl. The disclosed methods are superior to the prior art in that they allow for higher tolerability, improved safety, lower volumes, and improved patient compliance.Type: GrantFiled: August 2, 2024Date of Patent: May 6, 2025Assignee: Braintree Laboratories, Inc.Inventors: Edmund V. Dennett, Mark Cleveland, Russell W. Pelham, Matthew Walker
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Publication number: 20240325436Abstract: Disclosed herein are compositions comprising a mixture of salts that induce purgation of the colon and are useful to cleanse the colon. Furthermore, the disclosed compositions can comprise a flavoring agent and polyethylene glycol. The disclosed compositions are superior to prior art compositions in that the disclosed compositions allow for higher tolerability, lower volumes, and improved patient compliance. In some embodiments, the composition comprises non-fermentable carbohydrates. Methods for inducing purgation of the colon and for cleansing the colon are also disclosed.Type: ApplicationFiled: June 11, 2024Publication date: October 3, 2024Applicant: Braintree Laboratories, Inc.Inventors: Mark Cleveland, Edmund V. Dennett, JR., Russell W. Pelham, Matthew Walker
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Publication number: 20230263733Abstract: Disclosed herein are solid oral dosage formulations comprising sodium sulfate, magnesium sulfate, and potassium chloride for inducing purgation of the colon of a subject. Furthermore, the disclosed compositions and formulations are useful to cleanse the colon when administered in sufficient quantities. Methods for inducing purgation of the colon and for cleansing the colon are also disclosed.Type: ApplicationFiled: May 1, 2023Publication date: August 24, 2023Applicant: Braintree Laboratories, Inc.Inventors: Mark Cleveland, Edmund V. Dennett, JR., Russell W. Pelham
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Publication number: 20230256010Abstract: Disclosed herein are solid oral dosage formulations comprising sodium sulfate, magnesium sulfate, and potassium chloride for inducing purgation of the colon of a subject. Furthermore, the disclosed compositions and formulations are useful to cleanse the colon when administered in sufficient quantities. Methods for inducing purgation of the colon and for cleansing the colon are also disclosed.Type: ApplicationFiled: April 26, 2023Publication date: August 17, 2023Applicant: Braintree Laboratories, Inc.Inventors: Mark vB Cleveland, Edmund V. Dennett, JR., Russell W. Pelham
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Patent number: 11638697Abstract: Disclosed herein are solid oral dosage formulations comprising sodium sulfate, magnesium sulfate, and potassium chloride for inducing purgation of the colon of a subject. Furthermore, the disclosed compositions and formulations are useful to cleanse the colon when administered in sufficient quantities. Methods for inducing purgation of the colon and for cleansing the colon are also disclosed.Type: GrantFiled: June 7, 2021Date of Patent: May 2, 2023Assignee: Braintree Laboratories, Inc.Inventors: Mark vB Cleveland, Edmund V. Dennett, Jr., Russell W Pelham
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Patent number: 11382864Abstract: Disclosed herein are solid oral dosage formulations comprising sodium sulfate, magnesium sulfate, and potassium chloride for inducing purgation of the colon of a subject. Furthermore, the disclosed compositions and formulations are useful to cleanse the colon when administered in sufficient quantities. Methods for inducing purgation of the colon and for cleansing the colon are also disclosed.Type: GrantFiled: June 14, 2021Date of Patent: July 12, 2022Assignee: Braintree Laboratories, Inc.Inventors: Mark vB Cleveland, Edmund V. Dennett, Jr., Russell W Pelham
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Publication number: 20210299050Abstract: Disclosed herein are solid oral dosage formulations comprising sodium sulfate, magnesium sulfate, and potassium chloride for inducing purgation of the colon of a subject. Furthermore, the disclosed compositions and formulations are useful to cleanse the colon when administered in sufficient quantities. Methods for inducing purgation of the colon and for cleansing the colon are also disclosed.Type: ApplicationFiled: June 14, 2021Publication date: September 30, 2021Applicant: Braintree Laboratories, Inc.Inventors: Mark vB Cleveland, Edmund V. Dennett, JR., Russell W. Pelham
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Publication number: 20210290546Abstract: Disclosed herein are solid oral dosage formulations comprising sodium sulfate, magnesium sulfate, and potassium chloride for inducing purgation of the colon of a subject. Furthermore, the disclosed compositions and formulations are useful to cleanse the colon when administered in sufficient quantities. Methods for inducing purgation of the colon and for cleansing the colon are also disclosed.Type: ApplicationFiled: June 7, 2021Publication date: September 23, 2021Applicant: Braintree Laboratories, Inc.Inventors: Mark vB Cleveland, Edmund V. Dennett, JR., Russell W. Pelham
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Patent number: 11033498Abstract: Disclosed herein are solid oral dosage formulations comprising sodium sulfate, magnesium sulfate, and potassium chloride for inducing purgation of the colon of a subject. Furthermore, the disclosed compositions and formulations are useful to cleanse the colon when administered in sufficient quantities. Methods for inducing purgation of the colon and for cleansing the colon are also disclosed.Type: GrantFiled: December 3, 2018Date of Patent: June 15, 2021Assignee: Braintree Laboratories, Inc.Inventors: Mark vB. Cleveland, Edmund V. Dennett, Jr., Russell W. Pelham
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Publication number: 20190099375Abstract: Disclosed herein are solid oral dosage formulations comprising sodium sulfate, magnesium sulfate, and potassium chloride for inducing purgation of the colon of a subject. Furthermore, the disclosed compositions and formulations are useful to cleanse the colon when administered in sufficient quantities. Methods for inducing purgation of the colon and for cleansing the colon are also disclosed.Type: ApplicationFiled: December 3, 2018Publication date: April 4, 2019Applicant: Braintree Laboratories, Inc.Inventors: Mark vB. Cleveland, Edmund V. Dennett, JR., Russell W. Pelham
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Publication number: 20180207200Abstract: The present invention is generally directed to an oral pharmaceutical tablet composition comprising a sulfate salt, for example, sodium sulfate, wherein the composition is capable of administration by direct oral ingestion and by disintegration in water prior to oral ingestion. The present invention is further directed to use of such oral pharmaceutical tablet formulations to induce laxation or to treat or prevent constipation.Type: ApplicationFiled: January 31, 2018Publication date: July 26, 2018Applicant: Braintree Laboratories, Inc.Inventors: Edmund V. Dennett, JR., David S. Wells
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Patent number: 9919007Abstract: The present invention is generally directed to an oral pharmaceutical tablet composition comprising a sulfate salt, for example, sodium sulfate, wherein the composition is capable of administration by direct oral ingestion and by disintegration in water prior to oral ingestion. The present invention is further directed to use of such oral pharmaceutical tablet formulations to induce laxation or to treat or prevent constipation.Type: GrantFiled: March 14, 2014Date of Patent: March 20, 2018Assignee: Braintree Laboratories, Inc.Inventors: Edmund V. Dennett, Jr., David S. Wells
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Patent number: 9211337Abstract: The present invention provides a highly palatable colon cleansing formulation that utilizes a low chloride electrolyte-replenishing base solution. When formulated with polyethylene glycol and a selected sugar alcohol, the formulation offers the advantages of superior palatability without undesirable concomitant side effects or a decrease in cleansing efficacy.Type: GrantFiled: March 19, 2014Date of Patent: December 15, 2015Assignee: Braintree Laboratories, Inc.Inventor: William A. Shaver
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Patent number: 8753618Abstract: The present invention provides a highly palatable colon cleansing formulation that utilizes a low chloride electrolyte-replenishing base solution. When formulated with polyethylene glycol and a selected sugar alcohol, the formulation offers the advantages of superior palatability without undesirable concomitant side effects or a decrease in cleansing efficacy.Type: GrantFiled: December 13, 2011Date of Patent: June 17, 2014Assignee: Braintree Laboratories, Inc.Inventor: William A. Shaver
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Publication number: 20140087007Abstract: Disclosed is a method for rapidly cleansing the intestines and colon of a patient by orally administering an aqueous hypertonic sulfate solution, and then an aqueous isotonic solution to induce purgation, the purgations induced resulting in intestinal and colonic cleansing in less than four hours from the administration of the sulfate solution.Type: ApplicationFiled: March 15, 2013Publication date: March 27, 2014Applicant: Braintree Laboratories, Inc.Inventors: Mark vB. Cleveland, Edmund V. Dennett, JR., John D. McGowan
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Publication number: 20070298008Abstract: Stimulant laxative in combination with an osmotic laxative produces safe and effective bowel and colon cleansing with a reduced volume of liquid input. Administering to a patient an oral stimulant laxative, such as bisacodyl, followed, after a biologically determined interval, by a reduced volume of a PEG in water solution cleanses the bowels and colon in preparation for diagnostic colonoscopy, without the profuse uncontrollable diarrhea that typically follows either ingestion of large volume isotonic lavages, or smaller volume hypertonic lavages.Type: ApplicationFiled: August 28, 2007Publication date: December 27, 2007Applicant: Braintree Laboratories, Inc.Inventors: Edmund Dennett, Robert Raleigh, Mark Cleveland, Russell Pelham
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Patent number: 7291324Abstract: Stimulant laxative in combination with an osmotic laxative produces safe and effective bowel and colon cleansing with a reduced volume of liquid input. Administering to a patient an oral stimulant laxative, such as bisacodyl, followed, after a biologically determined interval, by a reduced volume of a PEG in water solution cleanses the bowels and colon in preparation for diagnostic colonoscopy, without the profuse uncontrollable diarrhea that typically follows either ingestion of large volume isotonic ravages, or smaller volume hypertonic lavages.Type: GrantFiled: October 22, 2002Date of Patent: November 6, 2007Assignee: Braintree Laboratories Inc.Inventors: Edmund V. Dennett, Jr., Robert M. Raleigh, Jr., Mark V B. Cleveland, Russell W. Pelham
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Publication number: 20070196322Abstract: An osmotic laxative followed by a bowel movement, followed by a stimulant laxative produces safe and effective cleansing of the colon with a minimal volume of liquid remaining in the colon in preparation for visualizing the interior of the colon by virtual colonoscopy. Administering to a patient a reduced volume of a PEG in water solution followed by an oral stimulant laxative, such as bisacodyl, after a biologically determined interval, cleanses the colon in preparation for the virtual colonoscopy, without the profuse uncontrollable diarrhea that typically follows either ingestion of the large volume isotonic lavages, or smaller volume hypertonic lavages.Type: ApplicationFiled: December 22, 2006Publication date: August 23, 2007Applicant: Braintree Laboratories Inc.Inventor: Russell Pelham
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Publication number: 20060029570Abstract: The present invention provides a polyethylene glycol liquid concentrate for treatment of constipation or for gastrointestinal lavage that is chemically stable and resistant to microbial contamination.Type: ApplicationFiled: November 17, 2004Publication date: February 9, 2006Applicant: Braintree Laboratories, Inc.Inventors: Bruce Aronson, Stanley Gay
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Patent number: 6946149Abstract: The field of colonic diagnostic and surgical procedures is hampered by the lack of optimal means available to cleanse the colon. A compromise between convenient, distasteful, solid or low volume, hyperosmotic solutions which cause considerable fluid and electrolyte imbalances in patients and large volume, difficult to consume, iso-osmotic solutions has had to be made heretofore. This invention describes a low volume, hyper-osmotic solution consisting of sulfate salts with and with out polyethylene glycol. Unlike prior art, this composition is useful for the cleansing of the bowel and, in lower volumes, as a laxative, without producing clinically significant changes in bodily function.Type: GrantFiled: April 30, 2002Date of Patent: September 20, 2005Assignee: Braintree Laboratories, Inc.Inventor: Mark vB. Cleveland