Patents Assigned to Braintree Laboratories, Inc.
  • Patent number: 12290529
    Abstract: Disclosed herein are methods of administering compositions comprising a mixture of salts that induce purgation of the colon and are useful to cleanse the colon. Furthermore, the disclosed methods prevent degradation of PEG and allow for cleansing of the colon without the use of adjunct laxatives, including stimulant laxatives such as bisacodyl. The disclosed methods are superior to the prior art in that they allow for higher tolerability, improved safety, lower volumes, and improved patient compliance.
    Type: Grant
    Filed: August 2, 2024
    Date of Patent: May 6, 2025
    Assignee: Braintree Laboratories, Inc.
    Inventors: Edmund V. Dennett, Mark Cleveland, Russell W. Pelham, Matthew Walker
  • Publication number: 20240325436
    Abstract: Disclosed herein are compositions comprising a mixture of salts that induce purgation of the colon and are useful to cleanse the colon. Furthermore, the disclosed compositions can comprise a flavoring agent and polyethylene glycol. The disclosed compositions are superior to prior art compositions in that the disclosed compositions allow for higher tolerability, lower volumes, and improved patient compliance. In some embodiments, the composition comprises non-fermentable carbohydrates. Methods for inducing purgation of the colon and for cleansing the colon are also disclosed.
    Type: Application
    Filed: June 11, 2024
    Publication date: October 3, 2024
    Applicant: Braintree Laboratories, Inc.
    Inventors: Mark Cleveland, Edmund V. Dennett, JR., Russell W. Pelham, Matthew Walker
  • Publication number: 20230263733
    Abstract: Disclosed herein are solid oral dosage formulations comprising sodium sulfate, magnesium sulfate, and potassium chloride for inducing purgation of the colon of a subject. Furthermore, the disclosed compositions and formulations are useful to cleanse the colon when administered in sufficient quantities. Methods for inducing purgation of the colon and for cleansing the colon are also disclosed.
    Type: Application
    Filed: May 1, 2023
    Publication date: August 24, 2023
    Applicant: Braintree Laboratories, Inc.
    Inventors: Mark Cleveland, Edmund V. Dennett, JR., Russell W. Pelham
  • Publication number: 20230256010
    Abstract: Disclosed herein are solid oral dosage formulations comprising sodium sulfate, magnesium sulfate, and potassium chloride for inducing purgation of the colon of a subject. Furthermore, the disclosed compositions and formulations are useful to cleanse the colon when administered in sufficient quantities. Methods for inducing purgation of the colon and for cleansing the colon are also disclosed.
    Type: Application
    Filed: April 26, 2023
    Publication date: August 17, 2023
    Applicant: Braintree Laboratories, Inc.
    Inventors: Mark vB Cleveland, Edmund V. Dennett, JR., Russell W. Pelham
  • Patent number: 11638697
    Abstract: Disclosed herein are solid oral dosage formulations comprising sodium sulfate, magnesium sulfate, and potassium chloride for inducing purgation of the colon of a subject. Furthermore, the disclosed compositions and formulations are useful to cleanse the colon when administered in sufficient quantities. Methods for inducing purgation of the colon and for cleansing the colon are also disclosed.
    Type: Grant
    Filed: June 7, 2021
    Date of Patent: May 2, 2023
    Assignee: Braintree Laboratories, Inc.
    Inventors: Mark vB Cleveland, Edmund V. Dennett, Jr., Russell W Pelham
  • Patent number: 11382864
    Abstract: Disclosed herein are solid oral dosage formulations comprising sodium sulfate, magnesium sulfate, and potassium chloride for inducing purgation of the colon of a subject. Furthermore, the disclosed compositions and formulations are useful to cleanse the colon when administered in sufficient quantities. Methods for inducing purgation of the colon and for cleansing the colon are also disclosed.
    Type: Grant
    Filed: June 14, 2021
    Date of Patent: July 12, 2022
    Assignee: Braintree Laboratories, Inc.
    Inventors: Mark vB Cleveland, Edmund V. Dennett, Jr., Russell W Pelham
  • Publication number: 20210299050
    Abstract: Disclosed herein are solid oral dosage formulations comprising sodium sulfate, magnesium sulfate, and potassium chloride for inducing purgation of the colon of a subject. Furthermore, the disclosed compositions and formulations are useful to cleanse the colon when administered in sufficient quantities. Methods for inducing purgation of the colon and for cleansing the colon are also disclosed.
    Type: Application
    Filed: June 14, 2021
    Publication date: September 30, 2021
    Applicant: Braintree Laboratories, Inc.
    Inventors: Mark vB Cleveland, Edmund V. Dennett, JR., Russell W. Pelham
  • Publication number: 20210290546
    Abstract: Disclosed herein are solid oral dosage formulations comprising sodium sulfate, magnesium sulfate, and potassium chloride for inducing purgation of the colon of a subject. Furthermore, the disclosed compositions and formulations are useful to cleanse the colon when administered in sufficient quantities. Methods for inducing purgation of the colon and for cleansing the colon are also disclosed.
    Type: Application
    Filed: June 7, 2021
    Publication date: September 23, 2021
    Applicant: Braintree Laboratories, Inc.
    Inventors: Mark vB Cleveland, Edmund V. Dennett, JR., Russell W. Pelham
  • Patent number: 11033498
    Abstract: Disclosed herein are solid oral dosage formulations comprising sodium sulfate, magnesium sulfate, and potassium chloride for inducing purgation of the colon of a subject. Furthermore, the disclosed compositions and formulations are useful to cleanse the colon when administered in sufficient quantities. Methods for inducing purgation of the colon and for cleansing the colon are also disclosed.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: June 15, 2021
    Assignee: Braintree Laboratories, Inc.
    Inventors: Mark vB. Cleveland, Edmund V. Dennett, Jr., Russell W. Pelham
  • Publication number: 20190099375
    Abstract: Disclosed herein are solid oral dosage formulations comprising sodium sulfate, magnesium sulfate, and potassium chloride for inducing purgation of the colon of a subject. Furthermore, the disclosed compositions and formulations are useful to cleanse the colon when administered in sufficient quantities. Methods for inducing purgation of the colon and for cleansing the colon are also disclosed.
    Type: Application
    Filed: December 3, 2018
    Publication date: April 4, 2019
    Applicant: Braintree Laboratories, Inc.
    Inventors: Mark vB. Cleveland, Edmund V. Dennett, JR., Russell W. Pelham
  • Publication number: 20180207200
    Abstract: The present invention is generally directed to an oral pharmaceutical tablet composition comprising a sulfate salt, for example, sodium sulfate, wherein the composition is capable of administration by direct oral ingestion and by disintegration in water prior to oral ingestion. The present invention is further directed to use of such oral pharmaceutical tablet formulations to induce laxation or to treat or prevent constipation.
    Type: Application
    Filed: January 31, 2018
    Publication date: July 26, 2018
    Applicant: Braintree Laboratories, Inc.
    Inventors: Edmund V. Dennett, JR., David S. Wells
  • Patent number: 9919007
    Abstract: The present invention is generally directed to an oral pharmaceutical tablet composition comprising a sulfate salt, for example, sodium sulfate, wherein the composition is capable of administration by direct oral ingestion and by disintegration in water prior to oral ingestion. The present invention is further directed to use of such oral pharmaceutical tablet formulations to induce laxation or to treat or prevent constipation.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: March 20, 2018
    Assignee: Braintree Laboratories, Inc.
    Inventors: Edmund V. Dennett, Jr., David S. Wells
  • Patent number: 9211337
    Abstract: The present invention provides a highly palatable colon cleansing formulation that utilizes a low chloride electrolyte-replenishing base solution. When formulated with polyethylene glycol and a selected sugar alcohol, the formulation offers the advantages of superior palatability without undesirable concomitant side effects or a decrease in cleansing efficacy.
    Type: Grant
    Filed: March 19, 2014
    Date of Patent: December 15, 2015
    Assignee: Braintree Laboratories, Inc.
    Inventor: William A. Shaver
  • Patent number: 8753618
    Abstract: The present invention provides a highly palatable colon cleansing formulation that utilizes a low chloride electrolyte-replenishing base solution. When formulated with polyethylene glycol and a selected sugar alcohol, the formulation offers the advantages of superior palatability without undesirable concomitant side effects or a decrease in cleansing efficacy.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: June 17, 2014
    Assignee: Braintree Laboratories, Inc.
    Inventor: William A. Shaver
  • Publication number: 20140087007
    Abstract: Disclosed is a method for rapidly cleansing the intestines and colon of a patient by orally administering an aqueous hypertonic sulfate solution, and then an aqueous isotonic solution to induce purgation, the purgations induced resulting in intestinal and colonic cleansing in less than four hours from the administration of the sulfate solution.
    Type: Application
    Filed: March 15, 2013
    Publication date: March 27, 2014
    Applicant: Braintree Laboratories, Inc.
    Inventors: Mark vB. Cleveland, Edmund V. Dennett, JR., John D. McGowan
  • Publication number: 20070298008
    Abstract: Stimulant laxative in combination with an osmotic laxative produces safe and effective bowel and colon cleansing with a reduced volume of liquid input. Administering to a patient an oral stimulant laxative, such as bisacodyl, followed, after a biologically determined interval, by a reduced volume of a PEG in water solution cleanses the bowels and colon in preparation for diagnostic colonoscopy, without the profuse uncontrollable diarrhea that typically follows either ingestion of large volume isotonic lavages, or smaller volume hypertonic lavages.
    Type: Application
    Filed: August 28, 2007
    Publication date: December 27, 2007
    Applicant: Braintree Laboratories, Inc.
    Inventors: Edmund Dennett, Robert Raleigh, Mark Cleveland, Russell Pelham
  • Patent number: 7291324
    Abstract: Stimulant laxative in combination with an osmotic laxative produces safe and effective bowel and colon cleansing with a reduced volume of liquid input. Administering to a patient an oral stimulant laxative, such as bisacodyl, followed, after a biologically determined interval, by a reduced volume of a PEG in water solution cleanses the bowels and colon in preparation for diagnostic colonoscopy, without the profuse uncontrollable diarrhea that typically follows either ingestion of large volume isotonic ravages, or smaller volume hypertonic lavages.
    Type: Grant
    Filed: October 22, 2002
    Date of Patent: November 6, 2007
    Assignee: Braintree Laboratories Inc.
    Inventors: Edmund V. Dennett, Jr., Robert M. Raleigh, Jr., Mark V B. Cleveland, Russell W. Pelham
  • Publication number: 20070196322
    Abstract: An osmotic laxative followed by a bowel movement, followed by a stimulant laxative produces safe and effective cleansing of the colon with a minimal volume of liquid remaining in the colon in preparation for visualizing the interior of the colon by virtual colonoscopy. Administering to a patient a reduced volume of a PEG in water solution followed by an oral stimulant laxative, such as bisacodyl, after a biologically determined interval, cleanses the colon in preparation for the virtual colonoscopy, without the profuse uncontrollable diarrhea that typically follows either ingestion of the large volume isotonic lavages, or smaller volume hypertonic lavages.
    Type: Application
    Filed: December 22, 2006
    Publication date: August 23, 2007
    Applicant: Braintree Laboratories Inc.
    Inventor: Russell Pelham
  • Publication number: 20060029570
    Abstract: The present invention provides a polyethylene glycol liquid concentrate for treatment of constipation or for gastrointestinal lavage that is chemically stable and resistant to microbial contamination.
    Type: Application
    Filed: November 17, 2004
    Publication date: February 9, 2006
    Applicant: Braintree Laboratories, Inc.
    Inventors: Bruce Aronson, Stanley Gay
  • Patent number: 6946149
    Abstract: The field of colonic diagnostic and surgical procedures is hampered by the lack of optimal means available to cleanse the colon. A compromise between convenient, distasteful, solid or low volume, hyperosmotic solutions which cause considerable fluid and electrolyte imbalances in patients and large volume, difficult to consume, iso-osmotic solutions has had to be made heretofore. This invention describes a low volume, hyper-osmotic solution consisting of sulfate salts with and with out polyethylene glycol. Unlike prior art, this composition is useful for the cleansing of the bowel and, in lower volumes, as a laxative, without producing clinically significant changes in bodily function.
    Type: Grant
    Filed: April 30, 2002
    Date of Patent: September 20, 2005
    Assignee: Braintree Laboratories, Inc.
    Inventor: Mark vB. Cleveland