Abstract: An ultrasound emitting device, configured to selectively and reversibly break the blood-brain barrier of a patient, including a structure configured to be placed on at least one portion of the head of the patient, at least two ultrasound transducers coupled to the structure and configured to emit ultrasounds of diagnostic intensity. Also, a method for improving the bioavailability in brain tissue of at least one inflammation mediator in a patient. Further, a method for treating diseases of the central nervous system using the method for improving the bioavailability of inflammation mediators in a patient in need thereof, and method for treating diseases of the central nervous system using the device. Finally, the use of the device for the treatment of diseases of the central nervous system.