Abstract: Loading and unloading device configured for connection to a truck or a trailer of truck, having a main support frame, a support frame supported in a position adjustable by the main frame and a cradle supported in a position adjustable by the main frame and defining with it a goods storage compartment, and means for handling the secondary frame and the cradle with respect to the main frame along one or more directions of second axes X, Y, Z which are orthogonal to modify the configuration of the compartment.