Abstract: Disclosed are systems and methods for generating and assessing data aggregations including defining audience characteristic data; querying a health database including health information and a health context database including health context information; aggregating the information into a set of data segments organized by age, gender, and geographic location, where the set of de-identified audience data segments is devoid of personally identifiable information (PII), including at least a count for the segment and values for the individual data points; assigning each of the data segments to an age bucket; calculating a probability distribution for the set of age buckets; calculating a probability score for each of the age buckets in the set using the probability distribution; querying a target database and appending the calculated probability score of the age bucket to one or more target data entries in the target database.