Abstract: The present invention are two crystalline salts, 17?-acetoxy-21-methoxy-11?-(4-,N,N-dimethylaminophenyl)-19 norpregna-4,9-diene-3,20-dione hydrochloride and 17?-acetoxy-21-methoxy-11?-(4-,N,N-dimethylaminophenyl)-19 norpregna-4,9-diene-3,20-dione hydrobromide, of the corresponding free base which is an amorphous solid.
Abstract: A novel process for making estra-4,9(10)-diene-3,17-dione steroids from readily available 19-nor-androst-4-ene-3-one steroids by a straightforward three-step process. Products of this process are important intermediates in the preparation of biologically active substances.
Type:
Grant
Filed:
June 6, 2002
Date of Patent:
November 2, 2004
Assignee:
Bridge Organics Co.
Inventors:
Verlan H. Van Rheenen, Edward J. Hessler