Patents Assigned to Brigham and Women's Hopsital
  • Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production
    Patent number: 10370645
    Abstract: Disclosed herein are cell cultures and enriched cell populations of endocrine precursor cells, immature pancreatic hormone-expressing cells and mature pancreatic hormone-expressing cells. Also disclosed herein are methods of producing such cell cultures and cell populations.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: August 6, 2019
    Assignees: Emory University, Dana-Farber Cancer Institute, Inc., Brigham and Women's Hopsital, Inc., President and Fellows of Harvard College
    Inventors: Kevin A. D'Amour, Anne Bang, Emmanuel E. Baetge
  • Inhibition of TNF-(&agr;)-initiated neutrophil response
    Patent number: 6387953
    Abstract: The impact of lipoxin A4 (LXA4) and aspirin-triggered-lipoxins (ATL) was investigated in tumor necrosis factor (TNF&agr;)-initiated neutrophil (PMN) responses in vitro and in vivo using metabolically stable LX analogs. At concentrations as low as 1-10 nM, the LXA4 and ATL analogs each inhibited TNF&agr;-stimulated superoxide anion generation and IL-1&bgr; release by human PMN.
    Type: Grant
    Filed: March 14, 2000
    Date of Patent: May 14, 2002
    Assignee: Brigham and Women's Hopsital
    Inventor: Charles N. Serhan