Abstract: Equol (7-hydroxy-3(4?hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5?-dihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the androgen receptor, thus altering growth and physiological hormone responses that are regulated by androgens. These data suggest a novel model to explain equol's biological properties. The significance of equol's ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment and prevention of androgen-mediated pathologies. Thus, equol can specifically bind DHT and prevent DHT's biological actions in physiological and pathophysiological processes.

Abstract: A method, apparatus, and system to remotely acquire information from volumes in a snowpack and to analyze the information are disclosed. Electromagnetic energy is transmitted remotely to a region of interest in a snowpack and data about reflections are processed to determine reflection values for different volumes within the snowpack. The frequency of the transmit signal is modulated and the positions from which energy is transmitted and received are changed to create a two-dimensional synthetic aperture that allows reflections from three-dimensional volumes to be discriminated and resolved. The electromagnetic energy is transmitted to ensure that it arrives at the snowpack at shallow grazing angles to maximize returns from volumes in the snow and to minimize boundary reflections from the ground.

Abstract: Systems and methods for dynamically analyzing temporality in an individual's speech in order to selectively categorize the speech fluency of the individual and/or to selectively provide speech training based on the results of the dynamic analysis. Temporal variables in one or more speech samples are dynamically quantified. The temporal variables in combination with a dynamic process, which is derived from analyses of temporality in the speech of native speakers and language learners, are used to provide a fluency score that identifies a proficiency of the individual. In some implementations, temporal variables are measured instantaneously.

Abstract: A friction stir welding anvil and method of producing a friction stir welding anvil that precludes diffusion or mechanical bonding of the anvil to the work pieces are provided. The alternatives for producing such an anvil comprise coating the anvil with diffusion barriers such as oxides, nitrides, intermetallics, and/or refractory metals; manufacturing an anvil either completely or partially from the same; or placing a coating of such materials in the form of a thin sheet or a powder between the anvil and the work pieces. The anvil disclosed herein exhibits high strength and hardness even at elevated temperatures, such as those greater than 800° C., so as to prevent the anvil from mechanically or diffusion bonding to the work pieces and so as to minimize, or eliminate altogether, anvil deformation.