Abstract: Disclosed herein are cationic steroidal antimicrobials (“CSAs” or “ceragenins”) and methods of making the same. Particularly advantageous methods are identified for the synthesis of CSAs. CSAs may be formulated for treating subjects with ailments responsive to CSAs, including but not limited to treating bacterial infections. Accordingly, some embodiments include formulations and methods of administering CSAs.

Abstract: A system for concurrent CAx workflow includes a collaborative server that manages a model of an engineering object, the model comprising at least design data and analysis data corresponding to the design data, a design client for editing of the design data by a design user, an analysis client for editing of the analysis data by an analysis user concurrent with editing of the design data by the design user; and wherein the collaborative server and the analysis client are collectively configured (i.e., one or both are configured) to enable the analysis user to edit the analysis data, view a plurality of geometric elements within the design data, and create a reference within the analysis data to a selected geometric element of the plurality of geometric elements within the design data. A corresponding apparatus, method, and computer-readable medium are also disclosed herein.

Abstract: The present disclosure as disclosed in various embodiments relates to methods and compositions of treating obesity, inflammation, or obesity-associated metabolic disorders with bacteriophages and processes for preparing the compositions.

Abstract: Techniques of preventing sabotage attacks in cyber-physical systems involve automatically identifying links between nodes of a graph representing cyber-physical systems as vulnerable to sabotage attacks according to a vulnerability metric for each link. The vulnerability metric used depends on the particular sabotage attack used to determine the vulnerable links. Once a computer configured to design cyber-physical systems based on vulnerability to sabotage attacks receives data representing the graph, the computer enumerates the possible links between nodes of the graph along which a sabotage attack may be performed. For each of those links, the computer computes the vulnerability metric. The computer then ranks the links according to respective values of the vulnerability metric. Based on the ranking, a designer may then perform a mitigation analysis that results in changes to the graph to reduce the vulnerability at each node accessible to a malicious actor.

Abstract: Methods of treating, reducing, or preventing a disease or symptom relating to a disease such as oral mucositis, gingivitis, periodontitis, gastric mucositis, inflammatory fibrosis, gastritis, colitis, ileitis, Crohn's disease, chronic inflammatory intestinal disease, inflammatory bowel syndrome, chronic inflammatory bowel disease, celiac disease, ulcerative colitis, a gastric ulcer, a peptic ulcer, a buccal ulcer, a nasopharyngeal ulcer, an esophageal ulcer, a duodenal ulcer, a gastrointestinal ulcer, an autoimmune disorder, inflammation associated with cancer, cancer treatment, or radiation, and/or pain that include: identifying a patient in need of treatment; and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.

Abstract: Superhydrophobic materials are disclosed and described, along with devices, surfaces, and associated methods. Such materials can be coated onto device surfaces, system surfaces, structures, and the like.

Abstract: A flexible electronics assembly includes a single-piece substrate having two regions of rigidity separated by a localized region of flexibility. The localized region of flexibility has a lower rigidity than the two regions of rigidity. The two regions of rigidity are angularly deflectable from a planar configuration of the single-piece substrate to a non-planar configuration of the single-piece substrate by hinging action of the localized region of flexibility. At least one electronic component is mounted on at least one of the two regions of rigidity.

Abstract: A multi-user CAx editing system may comprise a plurality of editing clients. The editing clients may be configured to maintain data consistency for geometric elements created within each local instance of a model of an engineering object. For example, each of the plurality of editing clients may include a synchronization module configured to identify one or more distinguishing parameters for each locally created geometric element and generate a unique persistent label for the geometric element, and communicate the unique persistent label and the distinguishing parameters to other editing clients. The communication may occur via a collaborative editing server. The other editing clients may find a geometric element within their local instance of the model that matches the distinguishing parameters and associate the unique persistent label with that geometric element. Subsequent references to the geometric element may be made by referring to the unique persistent label.

Abstract: Disclosed herein are methods of treating fungal infections in a patient, comprising identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.

Abstract: A method for multi-user CAx editing includes monitoring an operational state of a processor of a first CAx client, receiving, at a communication filter of the first CAx client, a first remote operation to be executed by the first CAx client in a CAx environment, populating the first remote operation to a queue formed in a memory structure in response to a determination that the operational state of the processor of the first CAx client is executing a local operation when the first remote operation is received, and executing the first remote operation in the CAx environment on the first CAx client in response to a determination that the operational state of the processor of the first CAx client is idle. A computer program product such as a computer readable medium and a computer system corresponding to the above method are also disclosed herein.

Abstract: An apparatus, method, and program product are disclosed for collaborative product lifecycle management. One apparatus includes a data processing module that receives product lifecycle management (“PLM”) data from multiple client applications in a collaborative environment. The PLM data may be in a client specific format. The apparatus includes a subscription module that receives one or more subscription requests from each client application. Moreover, the apparatus includes a conversion module that converts the PLM data from the client specific format to a generic format. The apparatus includes a storage module that stores the generic format of the PLM data. The conversion module may convert subscription data from the generic format to the client specific format. The subscription data may correspond to the PLM data stored in the generic format. The subscription module may provide the subscription data to the multiple client applications based on the one or more subscription requests.

Abstract: In a general aspect, an apparatus can include a porous, monolithic resonator having nanoscale pores defined therein. The apparatus can also include an adsorbent selective to a given analyte disposed on an exterior of the porous, monolithic resonator, the exterior of the porous, monolithic resonator including surfaces defining the nanoscale pores.

Abstract: A method for collaborative analysis pre-processing of electronic models of engineering objects includes assigning a first user to de-feature a model of an engineering object during a first session to provide a de-featured model of an engineering object, assigning a second user to conduct other FEA pre-processing operations on the model of the engineering object during a second session, and applying the other FEA pre-processing operations for the model of the engineering object to the de-featured model of the engineering object. Example of other FEA pre-processing operations include applying a material definition to a geometry, pre-meshing a geometry, initiating automated meshing of a geometry, validating automated meshing of a geometry, editing a mesh for a geometry, manually meshing a geometry, and defining one or more boundary conditions for a geometry. The second session and the first session may be conducted concurrently. A corresponding system and apparatus are also disclosed herein.

Abstract: An auto-injection syringe shaped similar to a credit card and having a biased injection mechanism operable to drive a needle into a user's body by a fixed distance to dispense a dose of fluid at a subcutaneous location. A safety may be provided to avoid undesired actuation of the injection mechanism. After the safety is bypassed, a trigger may be actuated by the user to allow operation of the injection mechanism. A reciprocating needle-cover resists casual view of the needle by the user during and after use of the syringe. A locking mechanism automatically holds the needle-cover at an extended position to isolate the needle from further contact and to resist re-use of the syringe.

Abstract: Disclosed herein are methods of making ceragnenin compounds for treating, preventing, or diagnosing diseases, disorders, or conditions associated with bacterial or viral infections, cancer, inflammation, and osteogenesis. Ceragenin compounds display broad-spectrum antibacterial activity utilizing a mode of action similar to antimicrobial peptides, but without the high synthesis costs and susceptibility to proteolytic degradation. Ceragenin compounds reproduce the amphiphilic morphology found in many antimicrobial peptides and display potent and diverse biological activities, including anti-bacterial, anti-cancer, anti-inflammatory, bone growth promotion, and wound healing promotion.

Abstract: A computer-implemented method for multi-user CAx editing of a model of a design object may include (1) identifying one or more geometric elements referenced in response to creating a feature within the model of the design object, (2) receiving a feature operation that references the geometric elements referenced in response to creating the feature, (3) in response to receiving the feature operation, identifying a geometric element referenced by the feature operation, and (4) generating a unique persistent label for the geometric element. Various other methods and systems are also disclosed herein.

Abstract: A system for three-dimensional (3D) optical trap printing (OTP) comprises a first particle susceptible to being cured by a light beam, a first light source to generate a trapping light beam to trap the particle, and a second light source to generate a curing light beam to cure the first particle. Using scanning and other optics, the trapping light beam may move the first particle to a desired printing location at which the curing light beam may cure the first particle, thereby adding the first particle to a printed structure. Using OTP, structures may be printed in any orientation, with or without support structures. Additionally, OTP allows for printing composite materials, high resolution color printing, printing of complex structures without sacrificial filler material, simultaneous printing of multiple particles, and combining particles at a print location.

Abstract: A method and system are disclosed for using circular symmetry to eliminate the angle limitations of an optical axis in a scanned aperture holography system. A Room-sized Holography System may be a scanned aperture holographic video display and may comprise a rotating platform, a telescope comprising a first lens and a second lens, and scanners at the Fourier plane where the focal length of the first lens and the second lens meet. The platform may rotate around an axis aligned with a spatial light modulator. When the platform rotates, the scanners rotate, thereby de-rotating a SAW image. The second lens may be a spherical reflective surface for redirecting light from the spatial light modulator, having passed through the first lens and reflected off a mirror-scanner, toward a user's eyes. The user may be on a chair above the spatial light modulator, wherein the chair is configured to rotate with the spatial light modulator.

Abstract: A method for collaborative finite analysis may include obtaining an electronic model of an engineering object, assigning users one or more geometries for pre-analysis editing to provide assigned geometries for each user, and enabling each user to conduct pre-analysis editing of their assigned geometries concurrent with other users. The method may also include conducting finite analysis on the assigned geometries of a first user concurrent with conducting finite analysis on the assigned geometries of a second user. Examples of pre-analysis editing include removing features that are secondary to analysis, applying a material definition to a geometry, pre-meshing a geometry, initiating automated meshing of a geometry, validating automated meshing of a geometry, editing a mesh for a geometry, manually meshing a geometry, defining one or more loads associated with a geometry, and defining one or more boundary conditions for a geometry. A corresponding system and apparatus are also disclosed herein.

Abstract: For automated detection and tracking of multiple targets, an apparatus, method, and program product are disclosed. The apparatus includes a camera that captures video data and a processor that compensates for camera motion in the video data, processes the compensated video data to remove noise and spurious returns, detects one or more targets within the processed video data, and identifies target information for each target in the processed video data.