Abstract: This disclosure provides a method of administrating to a subject a two-portion solution system in a specific ingesting order to yield a water-insoluble cross-linked hydrogel mass in the stomach. The volume of the formed water-insoluble cross-linked hydrogel mass is at least 50% v/v of the total volume of the two-portion solution system. The method is useful for preventing and treating overweight and obesity.

Abstract: This disclosure provides a pharmaceutical composition for oral administration, which comprises micronized ion-exchange resin particles having particle sizes less than 50 pm and at least one therapeutic agent releasably bound to the micronized resin particles through ionic interaction to form resin-therapeutic agent complexes. The resin-therapeutic agent complexes have particle sizes less than 50 pm, and the pharmaceutical composition is formulated as a dosage form providing uniform dispersion of the resin-therapeutic agent complexes with a substantially masked taste of the therapeutic agent, and a reduced gritty mouthfeel for geriatric patients and pediatric patients.

Abstract: This disclosure provides a pharmaceutical unit dose system. The unit dose system includes a unit-of-use self-dispersing dry composition for oral suspension. Also provided is a method for preparing a single unit dose of a dry pharmaceutical composition for oral administration. The unit dose system is advantageous in the convenience of use, dosing accuracy, long term storage, suspension uniformity over conventional multidose powder composition for oral suspension.