Abstract: Described, among other things, are dosage form for administration to a subject, the dosage forms having at least eight phytonutrients selected from resveratrol, berberine, epigallocatechin gallate, quercetin, dandelion root extract powder, curcuminoids, burdock root powder, Reishi mushroom extract powder, African mango seed extract, rosavins, ginkgolides, ellagic acid, Ginsengosides, and gingerols, The dosage forms can serve as biosignaling phytonutrient multi-supplement compositions capable of promoting a subject's health through the maintenance of at least one signal transduction cascade. In certain embodiments, the dosage form is administered to the, e.g., human female subject in order to reduce the symptoms of premenstrual syndrome in the subject.