Abstract: A modular chromatography column heating and temperature control system includes a heater base module with a compartment for the chromatography column that includes a heater plate. A set of heater blocks is provided in pairs, each heater block having opposite main faces in which are formed channels that match chromatography columns of different diameters. The heater blocks are mounted in pairs on the heater plate with the chromatography column held between them in matching channels on the two adjacent main faces of the heater blocks. An appropriate number of pairs of heater blocks are mounted to the heater plate so that the pairs of heater blocks cover as much of the length of the chromatography column as desired. The set of available pairs of heater blocks may include heater blocks of different lengths, so that appropriate selections of pairs of heater blocks can be made to best match the length of the chromatography column.