Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
Type:
Application
Filed:
March 8, 2016
Publication date:
February 15, 2018
Applicant:
Bristol-Myers Squibb Comapany
Inventors:
Peter W. Glunz, Doree F. Sitkoff, Mandar Shrikrishna Bodas, Navnath Dnyanoba Yadav, Sharanabasappa Patil, Prasanna Savanor Maddu Rao
Abstract: Disclosed are fused heterocyclic compounds of Formula (I): or pharmaceutically-acceptable salts or stereoisomers thereof. Also disclosed are methods of using such compounds in the treatment of at least one androgen receptor-associated condition, such as, for example, cancer, and pharmaceutical compositions comprising such compounds.
Type:
Application
Filed:
October 31, 2008
Publication date:
October 7, 2010
Applicant:
BRISTOL-MYERS SQUIBB COMAPANY
Inventors:
Weifang Shan, James Aaron Balog, Ashvinikumar V. Gavai, Yufen Zhao