Patents Assigned to Bristol-Myers Squibb Pharma Corporation
  • Lactams substituted by cyclic succinates as inhibitors of A? protein production
    Patent number: 7456278
    Abstract: This invention relates to novel lactams having the Formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A?-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to ?-amyloid production such as Alzheimer's disease and Down's Syndrome.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: November 25, 2008
    Assignee: Bristol-Myers Squibb Pharma Corporation
    Inventor: Richard E. Olson
  • Cyclic malonamides as inhibitors of A? protein production
    Patent number: 7390896
    Abstract: This invention relates to novel cyclic malonamides having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A?-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to ?-amyloid production such as Alzheimer's disease and Down's Syndrome.
    Type: Grant
    Filed: August 20, 2007
    Date of Patent: June 24, 2008
    Assignee: Bristol-Myers Squibb Pharma Corporation
    Inventors: Richard E. Olson, Michael G. Yang
  • Substituted lactams as inhibitors of A? protein production
    Patent number: 7390802
    Abstract: This invention relates to novel lactams of Formula (I): having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A?-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to ?-amyloid production such as Alzheimer's disease and Down's Syndrome.
    Type: Grant
    Filed: January 19, 2007
    Date of Patent: June 24, 2008
    Assignee: Bristol-Myers Squibb Pharma Corporation
    Inventors: Qi Han, Hong Liu, Richard E. Olson, Michael G. Yang