Patents Assigned to Bristol Myers Squibb S.P.A.
  • S-fluoro-anthracyclines, processes for their preparation and pharmaceutical compositions containing them
    Patent number: 5814608
    Abstract: 8-fluoro-anthracyclines of formula (I) have anti-tumor activity. ##STR1## wherein: R is chosen in the group consisting of H, OH, OR.sub.4 wherein R.sub.4 is chosen in the group consisting of CHO, COCH.sub.3, acyl derivative of a carboxylic acid containing up to 6 carbon atoms;R.sub.1 is chosen in the group consisting of: H, OH, OCH.sub.3 ;R.sub.2 is chosen in the group consisting of: H, OH, NH.sub.2R.sub.3 is chosen in the group consisting of: H, OH, NH.sub.2, residue of formula (A) ##STR2## The compounds are characterized by having cis-stereochemistry between the groups 8--F and 9--OH. Their preparation and pharmaceutical compositions containing them are also described.
    Type: Grant
    Filed: April 21, 1997
    Date of Patent: September 29, 1998
    Assignees: Bristol-Myers Squibb, S.p.A., A. Menarini Industrie Farmaceutiche Riunite S.R.L.
    Inventors: Fabio Animati, Federico Arcamone, Giuseppe Giannini, Paolo Lombardi, Edith Monteagudo
  • Antracycline disaccharides, process for their preparation, and pharmaceutical compositions containing them
    Patent number: 5801152
    Abstract: The present invention is referred to compounds of general formula (I) and (II), respectively ##STR1## their pharmaceutically acceptable salts, the process for their preparation, and the pharmaceutical compositions containing them.
    Type: Grant
    Filed: March 28, 1996
    Date of Patent: September 1, 1998
    Assignees: A. Menarini Industrie Farmaceutiche Riunite S.r.l., Bristol-Myers Squibb S.p.A.
    Inventors: Fabio Animati, Paolo Lombardi, Frederico Arcamone, Amalia Cipollone
  • Distamycin a derivatives as anti-malarial agents
    Patent number: 5670534
    Abstract: The present invention relates to Distamycin compounds of formula (I), methods of use and their pharmaceutical compositions.
    Type: Grant
    Filed: February 16, 1996
    Date of Patent: September 23, 1997
    Assignees: A. Menarini Industrie Farmaceutice Reunite S.R.L., Bristol Myers Squibb S.P.A.
    Inventors: Fabio Animati, Federico Arcamone, Paolo Lombardi, Cristina Rossi