Patents Assigned to Bristol-Myers Squibb
  • Hydrocolloid foam dressing
    Patent number: 6326524
    Abstract: The invention is a foamed, pressure sensitive, hydrocolloid adhesive for bonding to the body, and methods for its manufacture. The foamed structure of the adhesive itself improves absorbency, enables transmission of moisture through the adhesive, increases flexibility, and lowers product cost, all of which are key elements in making a product that is effective in adhering to the body.
    Type: Grant
    Filed: March 2, 2000
    Date of Patent: December 4, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: George F. Fattman, Richard F. Bayless
  • Fused pyridine inhibitors of cGMP phosphodiesterase
    Patent number: 6326379
    Abstract: Compounds of the formulas are useful as inhibitors of cGMP PDE, especially type V.
    Type: Grant
    Filed: September 10, 1999
    Date of Patent: December 4, 2001
    Assignee: Bristol-Myers Squibb Co.
    Inventors: John E. Macor, Guixue Yu
  • Assays and peptide substrate for determining aggrecan degrading metallo protease activity
    Patent number: 6326162
    Abstract: This invention is directed to assays to determine the presence or absence of proteins that exhibit aggrecanase or ADMP activity. This invention also relates to peptides that acts as a substrates for ADMPs, their use in various assays to determine the presence or absence of ADMP activity, and their use as inhibitors of ADMP activity.
    Type: Grant
    Filed: July 24, 1998
    Date of Patent: December 4, 2001
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Jeffrey A. Miller, Elizabeth C. Arner, Robert A. Copeland, Gary L. Davis, Ruiqin Liu, Michael Pratta, Micky D. Tortorella
  • Melatonin receptor-deficient mice and uses thereof
    Patent number: 6326526
    Abstract: Disclosed are mice containing a targeted disruption of various melatonin receptor subtypes, and methods of using the mice to identify agonists and antagonists of melatonin.
    Type: Grant
    Filed: January 7, 2000
    Date of Patent: December 4, 2001
    Assignees: Bristol-Myers Squibb Company, The General Hospital Corporation
    Inventors: Steven M. Reppert, Valentin K. Gribkoff
  • Process for azole antifungal intermediate
    Patent number: 6326509
    Abstract: An improved process is provided for synthesis of a halomethyl benzoic acid chloromethyl ester, a key intermediate for use in production of azole antifungal compounds and other pharmaceutical products.
    Type: Grant
    Filed: May 9, 2000
    Date of Patent: December 4, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Wangying Yang, Xuebao Wang, Apurba Bhattacharya, Melissa Chau
  • Process for the reduction of oxiranyl epothilones to olefinic epothilones
    Patent number: 6320045
    Abstract: The invention as claimed is directed to a process for making an epothilone having the following structures from ones having an oxiranyl moiety, by reacting a compound having the latter structure with a metal or metal-assisted reagent. Said metal or metal-assisted reagent is selected from the group consisting of a) reactive metallocenes; b) [N2C(CO2Me)2, cat Rh2,(OAC)4]; c) [N2C(CO2Me)2, cat[(n-C7H15CO2)2 Rh]2]; d) [Zn—Cu, EtOH]; e) [Mg(Hg), MgBr]; f) Cr; g) [FeCl3, n-BuLi]; h) [TiCl3, LiAlH4]; i) [TiCl4, Zn]; j) [WCl6, LiAlH4,]; k) [NbCl5, NaAlH4]; l) [VCl3,Zn] and m) [WCl6, n-BuLi].
    Type: Grant
    Filed: May 21, 1999
    Date of Patent: November 20, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Soong-Hoon Kim, James A. Johnson
  • Tibial knee component with a mobile bearing
    Patent number: 6319283
    Abstract: An orthopaedic knee component for implanting within a proximal tibia includes a tibial tray with a proximal tibial plateau and a projection extending generally orthogonal to the tibial plateau. The tibial tray also includes a distally extending stem. A bearing is coupled with the tibial plateau and has an articular bearing surface for engagement with a femoral component. The bearing is rotationally movable between a first rotational limit and a second rotational limit about an axis extending generally orthogonal to the tibial plateau. The bearing has a backing surface engaging the tibial plateau which is sized and shaped such that the backing surface is substantially entirely supported by the tibial plateau at any position during rotational movement between the first rotation limit and the second rotational limit.
    Type: Grant
    Filed: July 2, 1999
    Date of Patent: November 20, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: John Insall, Audrey Patmore, Christopher McLean, Linggawati Tanamal, Clayton R. Miller
  • Retinoid antagonists and uses thereof
    Patent number: 6319948
    Abstract: Retinoid antagonist compounds have been found to be useful in the prevention and/or minimization of surgical adhesion formation. Also provided by the invention are certain novel substituted (5,6)-dihydronaphthalenyl compounds which are retinoid antagonists and possess the above-mentioned property in addition to their use as antiinflammatory agents for chronic skin inflammatory diseases, as agents for the treatment of rheumatic diseases and as agents for the treatment of various tumors as well as non-malignant proliferative skin conditions.
    Type: Grant
    Filed: December 8, 2000
    Date of Patent: November 20, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Kenneth M. Tramposch, Xina Nair, Anne Marinier, Fred Christopher Zusi
  • Fused pyridopyridazine inhibitors of cGMP phosphodiesterase
    Patent number: 6316438
    Abstract: Compounds of the formula are useful as inhibitors of cGMP PDE especially Type 5.
    Type: Grant
    Filed: March 15, 2000
    Date of Patent: November 13, 2001
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Guixue Yu, John Macor, Soojin Kim, Hyei-Jha Chung, Michael Humora, Kishta Katipally, Yizhe Wang
  • Method of treating graft-versus-host disease with anti-GP39 antibodies and bone marrow cells
    Patent number: 6312692
    Abstract: A method of treating graft-vs-host diseases by administration of bone marrow and an anti-gp39 antibody specific to human gp39 is provided.
    Type: Grant
    Filed: April 30, 1998
    Date of Patent: November 6, 2001
    Assignees: Trustees of Dartmouth College, Bristol-Myers Squibb Company
    Inventors: Randolph J. Noelle, Teresa M. Foy, Alejandro Aruffo, Jeffrey A. Ledbetter
  • Method for treatment of anxiety and depression
    Patent number: 6312717
    Abstract: An improved method of treatment for anxiety and/or depression provides a quicker and more robust anxiolytic/antidepressant activity to a patient suffering from depression. The method comprises the concurrent administration of effective doses of certain azapirones, such as buspirone, given in a manner that suppresses formation of the 1-(2-pyrimidinyl)piperazine metabolite; and a 5-HT1A autosomal receptor antagonist, such as pindolol.
    Type: Grant
    Filed: June 14, 1999
    Date of Patent: November 6, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Perry B. Molinoff, Geoffrey C. Dunbar
  • Synthesis of melanoquaternary compounds and their use as hair dyes and for skin treatment
    Patent number: 6313313
    Abstract: Water soluble, cationic compounds useful as hair colorants or for the treatment of skin which are esters or amides formed by reaction of 5,6-dihydroxyindole-2-carboxylic acid or its N-substituted derivatives and a quaternary salt containing a reactive amino or hydroxyl group, and polymers from such compounds obtained by oxidative polymerization.
    Type: Grant
    Filed: September 18, 1998
    Date of Patent: November 6, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Gottfried Wenke, Giuseppe Prota
  • Methods for the preparation of biphenyl isoxazole sulfonamides
    Patent number: 6313308
    Abstract: Methods for the preparation of biphenyl isoxazole sulfonamides and intermediates therof. The present invention also relates to the novel intermediates prepared by these methods. The biphenyl isoxazole sulfonamides prepared by the present methods are endothelin antagonists useful, inter alia, for the treatment of hypertension, congestive heart failure and male erectile dysfunction.
    Type: Grant
    Filed: March 20, 2000
    Date of Patent: November 6, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ambarish Singh, Chien-Kuang Chen, John A. Grosso, Edward J. Delaney, Xuebao Wang, Richard P. Polniaszek, John K. Thottathil
  • &bgr;-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes
    Patent number: 6310201
    Abstract: Novel &bgr;-lactams finding utility as intermediates in the preparation of sidechain-bearing taxes such as tall and tall derivatives. The present invention also relates to novel methods of coupling &bgr;-lactams to form such sidechain-bearing taxes, and to novel sidechain-bearing taxes.
    Type: Grant
    Filed: June 11, 1999
    Date of Patent: October 30, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: John K. Thottathil, Ivan D. Trifunovich, David J. Kucera, Wen-Sen Li
  • Synthesis of paclitaxel from baccatin III by protection of the 7-hydroxyl of baccatin III using a strong base and an electrophile
    Patent number: 6307071
    Abstract: Process for synthesizing paclitaxel by treating baccatin III with a strong base in a solvent, adding an electrophile to the solution to form a 7-O-protected baccatin III derivative, reacting the 7-O-protected baccatin III derivative with a protected paclitaxel sidechain in a solvent such that the protected paclitaxel sidechain is coupled to the 13-hydroxyl of the 7-O-protected baccatin III, and subsequently deprotecting the protected paclitaxel sidechain and the 7-O protecting group to form paclitaxel, and intermediates used therein.
    Type: Grant
    Filed: February 1, 2000
    Date of Patent: October 23, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventor: Francis S. Gibson
  • Sonic impinging jet crystallization apparatus and process
    Patent number: 6302958
    Abstract: A novel apparatus and process for crystallizing submicron-sized crystals of a pharmaceutical composition. The submicron-sized crystals, which have an average size of less than 1 micron, provide high surface area end product crystals with greatly improved stability and purity, and which afford crystals having improved bioavailability, higher dissolution, decreased decomposition rate and longer shelf-life.
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: October 16, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Mark D. Lindrud, Soojin Kim, Chenkou Wei
  • Low odor permanent waving compositions containing a disulfide
    Patent number: 6302119
    Abstract: This invention provides compositions and methods for reducing odors associated with permanent hair waving by contacting the hair with a disulfide before, during, or after application of a sulfur-based reducing agent.
    Type: Grant
    Filed: December 6, 1999
    Date of Patent: October 16, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Janet Lynn Coope, Renee E. Nardone
  • Lactam inhibitors of FXa and method
    Patent number: 6297233
    Abstract: Caprolactam inhibitors are provided which have the structure including pharmaceutically acceptable salts thereof and all stereoisomers thereof, and prodrugs thereof, wherein n is 1 to 5; and and Y R1, R2, R3, R5, R5a, R6, R7, R8, R9 and R10 are as defined herein. These compounds are inhibitors of Factor Xa and thus are useful as anticoagulants. A method for treating cardiovascular diseases associated with thromboses is also provided.
    Type: Grant
    Filed: February 2, 2000
    Date of Patent: October 2, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Philip D. Stein, Gregory S. Bisacchi, Yan Shi, Stephen P. O'Connor, Chi Li
  • Carbamate derivatives of diaryl 1,3,4-oxadiazolone
    Patent number: 6297241
    Abstract: The present invention provides novel carbamate oxadiazolone derivatives having the general formula wherein R1 and R2 are as defined herein, or a nontoxic pharmaceutically acceptable salt or solvate thereof and are useful in the treatment of disorders which are responsive to the opening of the large conductance calcium-activated potassium channels.
    Type: Grant
    Filed: November 6, 2000
    Date of Patent: October 2, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Piyasena Hewawasam, Xi Chen, John E. Starrett
  • Process for the preparation of aziridinyl epothilones from oxiranyl epothilones
    Patent number: 6291684
    Abstract: The present invention relates to a stereospecific process to produce aziridinyl epothilones from oxiranyl epothilones and the intermediates derived therein.
    Type: Grant
    Filed: March 17, 2000
    Date of Patent: September 18, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert M. Borzilleri, Soong-Hoon Kim, Alicia Regueiro-Ren, Gregory D. Vite