Patents Assigned to British Bio-Technology Ltd.
  • Thrombin activatable plasminogen analogues
    Patent number: 5688664
    Abstract: A plasminogen analogue activatable by thrombin to have plasmin activity which contains the cleavage site sequence (SEQ ID NO: 23): ##STR1## where Xaa at position 1 represents P4; Xaa at position 2 represents P3; Xaa at position 5 represents P1'; and Xaa at position 6 represents P2' where P3 is a basic amino acid residue, P4 is a hydrophobic amino acid residue and each of P1' and P2' is independently a non-acidic amino acid residue, said site being cleavable by thrombin between Arg and P1'.
    Type: Grant
    Filed: October 29, 1993
    Date of Patent: November 18, 1997
    Assignee: British Bio-Technology Ltd.
    Inventors: Keith Martyn Dawson, Richard James Gilbert, Michael George Hunter