Abstract: Vaccines active against coccidiosis in domestic fowls contain attenuated precocious strains of Eimeria species.

Abstract: The invention relates to quinazoline derivatives or pharceutically-acceptable salts thereof, which possess anti-tumor activity; to processes for their manufacture; and to pharmaceutical compositions containing them.The invention provides a quinazoline of the formula: ##STR1## wherein R.sup.1 is (1-4C)alkyl; the quinazoline ring may optionally bear one or two further substituents selected from halogeno, (1-4C)alkyl and (1-4C)alkoxy;R.sup.2 is hydrogen or (1-4C)alkyl;R.sup.3 includes hydrogen and (1-4C)alkyl; andAr is optionally substituted phenylene or heterocyclene;or a pharmaceutically-acceptable salt or ester thereof.

Abstract: An endoprosthetic acetabular component of overall cup form is improved by the provision of an outer part (100; 300; 500) for securement to bone and a plurality of inner parts (200; 400; 600) individually selectively interconnectable with the outer part in like manner but providing a dished articulating surface (203; 403; 603) in respectively different predetermined positions varying in depth and/or inclination. The interconnection is preferably rotatably adjustable relative to the cup mouth, suitably by the provision of mutually complementary indented/detented surface formations (104,202; 304,402; 505,607) on the parts. The outer part may also be selectable from a range adapted to respectively different manners of securement to bone.

Abstract: The present invention relates to novel peptides isolated from the blowfly Calliphora vomitoria. The invention also relates to nucleic acid molecules encoding these peptides, vectors and host cells comprising these nucleic acid molecules, and chemical and biological methods for producing these peptides. The present peptides have novel sequences comprising hydroxyproline residues and C-terminal amide groups which give the peptides improved stability in the gut of insects. The peptides of the invention are related to the allatostatin class of insect neuropeptides, have inhibitory effects on gut motility in the blowfly C. vomitoria, and have allatostatic effects in cockroaches of the species Diploptera punctata and Periplaneta americana. The invention also provides compositions comprising the present peptides which may be used as insecticides, and provides methods of killing or controlling insects comprising administering the nucleic acid molecules, peptides or compositions of the invention to insects.

Abstract: By applying two or more electrical fields (DC, AC, pulsed) of different characteristics to an electrode array on e.g. the wall of a treatment cell, particles suspended in liquid in the cell may be manipulated as desired on a microscopic scale, in particular by exploiting the dielectrophoretic properties of the particles. The particles may be solid, semi-solid or liquid, and may be of simple materials or may be biological particles such as whole cells or fragments thereof.

Abstract: The invention relates to tricyclic compounds of formula (I) ##STR1## wherein R.sup.1 is hydrogen, amino, (1-4C)alkyl, (1-4C)alkoxy, hydroxy-(1-4C)alkyl or fluoro-(1-4C)alkyl; R.sup.2 is hydrogen, (1-4C)alkyl, (3-4C)alkenyl, (3-4C)alkynyl, hydroxy-(2-4C)alkyl, halogeno-(2-4C)alkyl or cyano-(1-4C)alkyl; Ar is optionally-substituted phenylene, thiophenediyl, thiazolediyl, pyridinediyl or pyrimidinediyl; and R.sup.3 includes a group of the formula --NHCH(CO.sub.2 H)--A.sup.1 --Y.sup.1 wherein A.sup.1 is (1-6C)alkylene and Y.sup.1 is carboxy, tetrazol-5-yl, N-?(1-4C)alkylsulphonyl!carbamoyl, N(phenylsulphonyl)carbamoyl, tetrazol-5-ylthio, tetrazol-5-ylsulphinyl or tetrazol-5-ylsulphonyl; or pharmaceutically-acceptable salts or esters thereof; to processes for their manufacture; to pharmaceutical compositions containing them; and to their use as anti-cancer agents.

Abstract: A method of verifying the identity of an individual comprises capturing an image of the subcutaneous vein pattern at a predetermined region of the individual, converting the captured image to a plurality of stored values representative of the intensity of said image at specified relative locations, processing the stored values to produce a second plurality of stored values representative of the image of the vein pattern having enhanced contrast and subjecting the second plurality of stored values to a thresholding process to select those above a predetermined value and storing a set of measurements derived from the selected ones of said second plurality of stored values for comparison with a corresponding set of measurements made on the individual.

Abstract: Optically non-linear materials suitable upon repeated Langmuir-Blodgett dipping for forming Z-type (head-to-tail) films for second harmonic generation include hemicyanine dyes which are very unsymmetrical, i.e. which have hydrophobic substituents differing in size by at least 4 carbon atoms, each end of a hydrophilic chromophore. A suitable dye is E-N-octadecyl-4-?2-(4-dibutylaminophenyl)ethenyl!quinolinium iodide.

Abstract: A high pressure pre-mixed analgesic anaesthetic gas composition comprising a life supporting gas and a volatile analgesic anaesthetic mixture; characterised in that the mixture comprises a first and a second anaesthetic analgesic, said first analgesic having blood/gas solubility co-efficient .lambda. significantly in excess of the .lambda. of the second analgesic.

Abstract: A structurally modified protein is provided that will bind to a tumor-associated structure wherein the amino group in at least one basic amino acid in the binding protein is structurally modified to convert the amino group, --NH.sub.2, to the grouping --NH--CO--X--NHR in which R is H or an amino protecting group and the grouping --CO--X--NHR is the residue of a peptide of the formula NHR--X--COOH capable of acting as a substrate for a phosphokinase.

Abstract: An implantable prosthetic patellar component comprises a patellar part (1) having one side (1a) adapted to be secured to the inner surface of a natural patella (10), and a femoral part (3) having one side (5) defining an articulation surface to replace the femoral facet of the patella, the opposite surfaces (1b and 3a) of said parts being mutually engageable to afford sliding movement therebetween in a medio-lateral direction.The implant is able to accommodate relative medio-lateral movement and thereby improve congruency. It may be used in combination with other prosthetic components in a knee joint.

Abstract: A laser ultrasound probe, suitable for intravascular use, of the kind having an ultrasonic transducer element comprising an ultrasound receiving surface of piezoelectric polymeric material and an optical fiber with one end directed forwardly from that surface and arranged to receive laser radiation for transmission through the optical fiber and emission from the said one end thereof, wherein the optical fiber is coupled with laser source means adapted to provide alternatively a relatively low average power laser beam, which, when modulated or pulsed and emitted from the one end of the optical fiber and incident on a target, will generate ultrasound at an intensity suitable to be received by the transducer element and converted thereby into electrical monitoring signals, and a relatively high average power laser beam suitable, when incident on the said target, to produce ablation thereof, the transducer element being sufficiently robust to withstand the ultrasound which is then also generated.

Abstract: The invention provides a composition for sustaining plant material comprising an aminopurine or a derivative or salt thereof and at least one water soluble sulfonated polyester or sulfonamide.

Abstract: Compounds of formula (I) ##STR1## in which X represents a group >O, >S, >C.dbd.O or >NR wherein R is hydrogen, C.sub.1-6 alkyl, phenyl or C.sub.7-12 phenalkyl, R.sub.1 and R.sub.2 each represent hydrogen or together represent an oxo group and R.sub.3, R.sub.4 and R.sub.5 each represent hydrogen or R.sub.1 represents hydrogen and two of R.sub.2, R.sub.3, R.sub.4 and R.sub.5 together represent the second bond of a double bond joining positions 7 and 8, 8 and 9 or 9 and 10 with the remaining two of R.sub.2, R.sub.3, R.sub.4 and R.sub.5 representing hydrogen, the compound optionally being in the form of a salt thereof formed with a physiologically acceptable inorganic or organic acid, are of value for the treatment of anxiety and in the improvement of learning ability and/or the reversal of amnesia.

Abstract: A chimaeric protein is provided, capable of forming part of a capsid assembly and comprising the amino acid sequence of the coat protein of phage MS-2, or a conservatively modified variant thereof, or sufficient of said sequence or variant to retain the capability of forming a capsid assembly, which amino acid sequence has been modified by removal of the cysteine residues present externally of the N-terminal protruberant .beta.-hairpin of the coat protein and insertion of a cysteine residue within the region corresponding to the N-terminal protruberant .beta.-hairpin.

Abstract: The invention provides a physiologically acceptable polymer comprising a backbone to which are attached guanidino groups, the polymer having a minimum molecular weight of 10,000. The invention also extends to foodstuffs and pharmaceutical compositions comprising the physiologically acceptable polymer. Such foodstuffs and compositions are of value in controlling phosphate levels in the body.

Abstract: Nucleoside thiotriphosphates carrying .sup.32 P in the gamma-thiophosphate group, prepared by reaction between a nucleoside diphosphate and .sup.32 p labelled thiophosphate salt, are used as thiophosphorylating agents for antibodies that bind to tumour-associated antigens. The labelled thiotriphosphates can be used to introduce a therapeutically useful .sup.32 P atom into an antibody that has been modified by the incorporation into its structute of a peptide region capable of acting as a substrate for a phosphokinase. The resulting labelled antibody can then be used for injection in anti-tumour therapy and has clinical advantages over the corresponding phosphoylated analogue.

Abstract: A device to facilitate self-catheterisation in women suffering from deviation from normal bladder function is provided. The device includes a handle designed for manipulation by a patient and a catheter co-operable with the handle such that the catheter can be inserted into the patient's urethra by manipulation of the handle. The device has a flexion portion to allow the catheter to be positioned in a desired orientation relative to the handle for ease of insertion. The handle and catheter may be designed as a one-piece disposable construction or may be separate elements, the handle being useable with disposable catheters. The flexion portion may be an articulation structure, such as a ball-and-socket joint. Catheterisation is further facilitated by the provision of a mirror and/or light source on or associated with the handle.

Abstract: Pharmaceutical compositions containing a 3-hydroxypyrid-2-one or 3-hydroxypyrid one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic acyl group, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by one or, except in the case of ionizable groups, more than one substituent selected from aliphatic acyl, alkoxy, aliphatic amine, aliphatic amide, carboxy, aliphatic ester, halogen, hydroxy and sulpho groups and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by one of said substituents, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by an alkoxy, aliphatic ester, halogen or hydroxy group, but excluding compounds in which said replacement of hydrogen atoms in the compound is effected only by aliphatic hydrocarbon groups, or a salt thereof containing a physiologically acceptable ion or ions, are of value for removing toxic amounts of metals, particularly iron, f

Abstract: Pharmaceutical compositions containing an iron complex of a 3-hydroxypyrid-2-one or 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic acyl group, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by one or, except in the case of ionizable groups, more than one substituent selected from aliphatic acyl, alkoxy, aliphatic amine, aliphatic amide, carboxy, aliphatic ester, halogen, hydroxy and sulpho groups and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by one of said substituents, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by an alkoxy, aliphatic ester, halogen or hydroxy group, but excluding compounds in which said replacement of hydrogen atoms in the compound is effected only by aliphatic hydrocarbon groups, are of value for the treatment of iron deficiency anemia.