Abstract: The invention relates to an improved process for preparing [(1R), 2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester of the formula: Compound I has been shown to be useful for the treatment of certain types of cancer.
Type:
Grant
Filed:
April 20, 2007
Date of Patent:
March 2, 2010
Assignee:
Britsol-Myers Squibb Company
Inventors:
Gerard A. Crispino, Mourad Hamedi, Thomas L. LaPorte, John E. Thornton, Jaan A. Pesti, Zhongmin Xu, Paul C. Lobben, David K. Leahy, Jale Muslehiddinoglu, Chiajen Lai, Lori Ann Spangler, Robert P. Discordia, Francis S. Gibson
Abstract: Disclosed are anthranilic acid derivatives having Formula (I): and pharmaceutically acceptable salts thereof; and pharmaceutical compositions comprising such compounds. Also disclosed are methods of using such compounds in the treatment of conditions or diseases such as prostate cancer, and methods of using such compounds in the inhibition of 17?-hydroxysteroid dehydrogenase type 3 enzyme.
Type:
Grant
Filed:
October 21, 2005
Date of Patent:
August 4, 2009
Assignee:
Britsol-Myers Squibb Company
Inventors:
Ellen K. Kick, R. Michael Lawrence, Brian E. Fink, Raj N. Misra, Gregory D. Vite
Abstract: A system for mixing and dispensing oxygen sensitive hair dye consists of concentrates in a sealed air-tight system using preferably 3--8 dye concentrates in collapsible bags having an oxygen barrier. The dye concentrates, along with oxygen activating liquids, are sufficient to produce an infinite number of hair dye formulations, thereby avoiding buying and stocking many bottles of specific color dyes. For formulating the dye mixtures, exact charges, i.e., volumes measured to within 1 ml, are raised from the bags and discharged. Each bag is removably connected, in an air-tight seal, to a separate precision lift pump whose piston lift excursion may be selectively set to determine the volume of the dye charge.