Abstract: Disclosed herein is a composition comprising: an amount of water; a non-water-soluble substance; and a first excipient, wherein the composition is configured to form a flowable ice slurry when exposed to freezing temperatures. Also disclosed herein is a method of preparing a cold slurry for administration to a patient at a clinical point of care, the method comprising: preparing a composition comprising a plurality of lipid particles; adding an excipient to the composition, wherein the excipient is configured to reduce the freezing point of a volume external to the plurality of lipid particles and of a volume internal to the plurality of lipid particles; and cooling the composition to a predetermined temperature such that the cold slurry is formed, wherein the cold slurry comprises a plurality of ice particles.

Abstract: The present disclosure relates to compositions and methods for manufacturing biomaterials that form flowable and injectable cold slurries. More particularly, the present disclosure relates to a composition containing a plurality of liposomes where the encapsulated internal liposomal media and external liposomal media have different freezing points.

Abstract: Disclosed herein is a system for creating an injectable and flowable cold slurry, the system comprising a housing; a mount operatively connected to the housing configured to accept a container; a first motor configured to move the mount from a first position to a second position; a second motor; and a drive shaft in communication with the second motor, wherein the drive shaft is configured to rotate to cause an internal volume of the container to be transformed into the injectable and flowable cold slurry.