Patents Assigned to Broaden BioScience and Technology Corp.
  • CHIMERIC ANTIGEN RECEPTOR WITH MODIFIED HINGE REGION AND USES THEREOF
    Publication number: 20230381230
    Abstract: The present disclosure provides a chimeric antigen receptor (CAR) molecule comprising a modified hinge domain, wherein the hinge domain comprises the amino acid sequence of SEQ ID NO:1. Cells expressing a CAR comprising the modified hinge domain disclosed herein are shown to have enhanced anti-tumor activities with reduced release of pro-inflammatory cytokines.
    Type: Application
    Filed: October 27, 2022
    Publication date: November 30, 2023
    Applicants: Orgenesis Inc., Broaden BioScience and Technology Corp.
    Inventors: BUO CHEN, Xiangqun LI, Ang Zhang