Patents Assigned to Broaden BioScience and Technology Corp.
  • ONCOLYTIC VIRUS COMBINED WITH CAR T CELLS FOR ANTI-TUMOR THERAPY
    Publication number: 20240131096
    Abstract: The present disclosure provides methods of treating cancer using complementary transgenic oncolytic viruses and genetically engineered CAR T cells. In one embodiment, the oncolytic virus comprises nucleotide sequences encoding CD19, or CD19 and IL-12, and the genetically engineered T cells express a chimeric antigen receptor that recognizes CD19.
    Type: Application
    Filed: October 23, 2023
    Publication date: April 25, 2024
    Applicants: Broaden Bioscience and Technology Corp, Orgenesis, Inc, Joint BioSciences Ltd
    Inventors: BUO CHEN, GUOQING ZHOU, XIANGGUM LI
  • CHIMERIC ANTIGEN RECEPTOR WITH MODIFIED HINGE REGION AND USES THEREOF
    Publication number: 20230381230
    Abstract: The present disclosure provides a chimeric antigen receptor (CAR) molecule comprising a modified hinge domain, wherein the hinge domain comprises the amino acid sequence of SEQ ID NO:1. Cells expressing a CAR comprising the modified hinge domain disclosed herein are shown to have enhanced anti-tumor activities with reduced release of pro-inflammatory cytokines.
    Type: Application
    Filed: October 27, 2022
    Publication date: November 30, 2023
    Applicants: Orgenesis Inc., Broaden BioScience and Technology Corp.
    Inventors: BUO CHEN, Xiangqun LI, Ang Zhang