Patents Assigned to Brookhaven Science Associates
  • Publication number: 20130178357
    Abstract: A method of synthesizing activated electrocatalyst, preferably having a morphology of a nanostructure, is disclosed. The method includes safely and efficiently removing surfactants and capping agents from the surface of the metal structures. With regard to metal nanoparticles, the method includes synthesis of nanoparticle(s) in polar or non-polar solution with surfactants or capping agents and subsequent activation by CO-adsorption-induced surfactant/capping agent desorption and electrochemical oxidation. The method produces activated macroparticle or nanoparticle electrocatalysts without damaging the surface of the electrocatalyst that includes breaking, increasing particle thickness or increasing the number of low coordination sites.
    Type: Application
    Filed: January 7, 2013
    Publication date: July 11, 2013
    Applicant: Brookhaven Science Associates, LLC
    Inventor: Brookhaven Science Associates, LLC
  • Publication number: 20130157133
    Abstract: A method of synthesizing defect-free phospho-olivine materials is disclosed. The method is based on direct hydrothermal synthesis of phospho-olivine compound(s) and subsequent lattice reordering at or near the transition temperature to eliminate lattice defects or on one-pot in situ hydrothermal synthesis of phospho-olivine compound(s), where the cation ordering occurs during dwell time after rapid synthesis to eliminate lattice defects. The disclosed methods produce defect-free phospho-olivine compound(s) having a crystal lattice with a Pnma space group. In order to determine the exact transition temperature for complete removal of single- or mixed-transition metals from lithium sites or to monitor the crystal growth and removal of single- or mixed-transition metals from lithium sites during the hydrothermal synthesis, the method encompasses a procedure for determining and monitoring defects in the phospho-olivine phases using X-ray diffraction.
    Type: Application
    Filed: November 14, 2012
    Publication date: June 20, 2013
    Applicant: Brookhaven Science Associates, LLC
    Inventor: Brookhaven Science Associates, LLC
  • Publication number: 20130150240
    Abstract: The present invention relates to a novel species of Enterobacter, Enterobacter sp. 638, and to its use in connection, for example, with a method for increasing growth in a plant, increasing biomass in a plant, increasing fruit and/or seed productivity in a plant, increasing disease tolerance and/or resistance in a plant, and increasing drought tolerance and/or resistance in a plant, as compared to a control or wild-type plant grown under identical conditions without application of the inventive method or composition. The methods include applying an effective amount of a composition, which includes an isolated culture of Enterobacter sp. 638, to the plant.
    Type: Application
    Filed: March 10, 2011
    Publication date: June 13, 2013
    Applicant: BROOKHAVEN SCIENCE ASSOCIATES/BROOKHAVEN NATIONAL LABORATORY
    Inventors: Lee Newman, Daniel van der Lelie, Safiyh Taghavi
  • Publication number: 20130146843
    Abstract: Vapor-liquid-solid growth of nanowires is tailored to achieve complex one-dimensional material geometries using phase diagrams determined for nanoscale materials. Segmented one-dimensional nanowires having constant composition display locally variable electronic band structures that are determined by the diameter of the nanowires. The unique electrical and optical properties of the segmented nanowires are exploited to form electronic and optoelectronic devices. Using gold-germanium as a model system, in situ transmission electron microscopy establishes, for nanometer-sized Au—Ge alloy drops at the tips of Ge nanowires (NWs), the parts of the phase diagram that determine their temperature-dependent equilibrium composition. The nanoscale phase diagram is then used to determine the exchange of material between the NW and the drop. The phase diagram for the nanoscale drop deviates significantly from that of the bulk alloy.
    Type: Application
    Filed: February 1, 2013
    Publication date: June 13, 2013
    Applicant: Brookhaven Science Associates, LLC
    Inventor: Brookhaven Science Associates, LLC
  • Publication number: 20130137602
    Abstract: The present invention is directed to nanoscale fabrication of nano-materials with application in electronics, energy conversion, bio-sensing and others. Specifically, the invention is directed to arbitrary, that is periodic and non-periodic, assembly of nano-objects on I D and 2D arrays. The present invention utilizes self-organization properties of nanoscale bio-encoded building blocks, programmability of biomolecular interactions, and simple processing techniques for providing arbitrary by-design fabrication capability. Specifically, the present invention utilizes double stranded DNA attached to a surface and intercalating PNA-DNA hybrids attached to nano-objects to bind the nano-objects to the dsDNA in a site specific manner. The present invention allows for an integration of a large number of nano-components in unified well-defined systems.
    Type: Application
    Filed: March 7, 2011
    Publication date: May 30, 2013
    Applicant: Brookhaven Science Associates, LLC
    Inventors: Oleg Gang, Daniel van der Lelie
  • Patent number: 8449816
    Abstract: A composition suitable for use as a target containing antimony to be irradiated by accelerated charged particles (e.g., by protons to produce tin-117m) comprises an intermetallic compound of antimony and titanium which is synthesized at high-temperature, for example, in an arc furnace. The formed material is powdered and melted in an induction furnace, or heated at high gas pressure in gas static camera. The obtained product has a density, temperature stability, and heat conductivity sufficient to provide an appropriate target material.
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: May 28, 2013
    Assignee: Brookhaven Science Associates
    Inventors: Yurii D. Seropeghin, Boris L. Zhuikov
  • Publication number: 20130126746
    Abstract: A novel radiation detector system is disclosed that solves the electron trapping problem by optimizing shielding of the individual virtual Frisch-grid detectors in an array configuration.
    Type: Application
    Filed: May 2, 2011
    Publication date: May 23, 2013
    Applicant: BROOKHAVEN SCIENCE ASSOCIATES, LLC
    Inventors: Aleksey E. Bolotnikov, Ge Yang, Giuseppe Camarda, Yonggang Cui, Anwar Hossain, Ki Hyun Kim, Ralph B. James
  • Patent number: 8444953
    Abstract: The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity halogenated, carborane-containing 5,10,15,20-tetraphenylporphyrin compounds and methods for their use particularly in boron neutron capture therapy (BNCT) and photodynamic therapy (PDT) for the treatment of tumors of the brain, head and neck, and surrounding tissue. The invention is also directed to using these halogenated, carborane-containing tetraphenylporphyrin compounds in methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET.
    Type: Grant
    Filed: March 22, 2007
    Date of Patent: May 21, 2013
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Michiko Miura, Haitao Wu
  • Patent number: 8426833
    Abstract: A particle therapy gantry for delivering a particle beam to a patient includes a beam tube having a curvature defining a particle beam path and a plurality of superconducting, variable field magnets sequentially arranged along the beam tube for guiding the particle beam along the particle path. In a method for delivering a particle beam to a patient through a gantry, a particle beam is guided by a plurality of variable field magnets sequentially arranged along a beam tube of the gantry and the beam is alternately focused and defocused with alternately arranged focusing and defocusing variable field magnets.
    Type: Grant
    Filed: December 9, 2011
    Date of Patent: April 23, 2013
    Assignee: Brookhaven Science Associates, LLC
    Inventor: Dejan Trbojevic
  • Patent number: 8415344
    Abstract: Methods for treatment of depression-related mood disorders in mammals, particularly humans are disclosed. The methods of the invention include administration of compounds capable of enhancing glutamate transporter activity in the brain of mammals suffering from depression. ATP-sensitive K+ channel openers and ?-lactam antibiotics are used to enhance glutamate transport and to treat depression-related mood disorders and depressive symptoms.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: April 9, 2013
    Assignee: Brookhaven Science Associates, LLC
    Inventor: Fritz Henn
  • Patent number: 8404613
    Abstract: High-surface-area carbon nanostructures coated with a smooth and conformal submonolayer-to-multilayer thin metal films and their method of manufacture are described. The preferred manufacturing process involves the initial oxidation of the carbon nanostructures followed by immersion in a solution with the desired pH to create negative surface dipoles. The nanostructures are subsequently immersed in an alkaline solution containing non-noble metal ions which adsorb at surface reaction sites. The metal ions are then reduced via chemical or electrical means and the nanostructures are exposed to a solution containing a salt of one or more noble metals which replace adsorbed non-noble surface metal atoms by galvanic displacement. Subsequent film growth may be performed via the initial quasi-underpotential deposition of a non-noble metal followed by immersion in a solution comprising a more noble metal.
    Type: Grant
    Filed: February 22, 2010
    Date of Patent: March 26, 2013
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Radoslav Adzic, Alexander Harris
  • Patent number: 8399217
    Abstract: A method for promoting and suppressing auto-induction of transcription of a cloned gene 1 of bacteriophage T7 in cultures of bacterial cells grown batchwise is disclosed. The transcription is under the control of a promoter whose activity can be induced by an exogenous inducer whose ability to induce said promoter is dependent on the metabolic state of said bacterial cells.
    Type: Grant
    Filed: April 27, 2007
    Date of Patent: March 19, 2013
    Assignee: Brookhaven Science Associates, LLC
    Inventor: F. William Studier
  • Publication number: 20130056359
    Abstract: An apparatus and method for the synthesis and treatment of electrocatalyst particles in batch or continuous fashion is provided. In one embodiment, the apparatus is comprised of a three-electrode cell which includes a reference electrode, a counter electrode, and a working electrode. The working electrode is preferably a cylindrical vessel having an electrically conductive region. The electrode assembly is introduced into a slurry containing metal ions and a plurality of particles. During operation an electrical potential is applied and the working electrode is rotated at a predetermined speed. When particles in the slurry collide with the electrically conductive region the transferred charge facilitates deposition of an ad-layer of the desired metal. In this manner film growth can commence on a large number of particles simultaneously. This process is especially suitable as a commercial thin film deposition process for forming catalytically active layers on nanoparticles for use in energy conversion devices.
    Type: Application
    Filed: March 24, 2011
    Publication date: March 7, 2013
    Applicant: BROOKHAVEN SCIENCE ASSOCIATES LLC
    Inventors: Radoslav Adzic, Miomir Vukmirovic
  • Patent number: 8389387
    Abstract: Vapor-liquid-solid growth of nanowires is tailored to achieve complex one-dimensional material geometries using phase diagrams determined for nanoscale materials. Segmented one-dimensional nanowires having constant composition display locally variable electronic band structures that are determined by the diameter of the nanowires. The unique electrical and optical properties of the segmented nanowires are exploited to form electronic and optoelectronic devices. Using gold-germanium as a model system, in situ transmission electron microscopy establishes, for nanometer-sized Au—Ge alloy drops at the tips of Ge nanowires (NWs), the parts of the phase diagram that determine their temperature-dependent equilibrium composition. The nanoscale phase diagram is then used to determine the exchange of material between the NW and the drop. The phase diagram for the nanoscale drop deviates significantly from that of the bulk alloy.
    Type: Grant
    Filed: January 6, 2010
    Date of Patent: March 5, 2013
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Eli Anguelova Sutter, Peter Werner Sutter
  • Publication number: 20130045151
    Abstract: A method for providing 11C-labeled cyanides from 11C labeled oxides in a target gas stream retrieved from an irradiated high pressure gaseous target containing O2, wherein 11C labeled oxides are reduced with H2 in the presence of a nickel catalyst under a pressure and a temperature sufficient to form a product stream comprising at least about 95% 11CH4, the 11CH4 is then combined with an excess of NH3 in a carrier/reaction stream flowing at an accelerated velocity and the combined 11CH4 carrier/reaction stream is then contacted with a platinum (Pt) catalyst particulate supported on a substantially-chemically-nonreactive heat-stable support at a temperature of at least about 900° C., whereby a product stream comprising at least about 60% H11CN is provided in less than 10 minutes from retrieval of the 11C labeled oxide.
    Type: Application
    Filed: August 13, 2012
    Publication date: February 21, 2013
    Applicant: Brookhaven Science Associates, LLC
    Inventors: Dohyun Kim, David Alexoff, Sung Won Kim, Jacob Hooker, Richard A. Ferrieri
  • Publication number: 20130045328
    Abstract: High-surface-area carbon nanostructures coated with a smooth and conformal submonolayer-to-multilayer thin metal films and their method of manufacture are described. The preferred manufacturing process involves the initial oxidation of the carbon nanostructures followed by a surface preparation process involving immersion in a solution with the desired pH to create negative surface dipoles. The nanostructures are subsequently immersed in an alkaline solution containing a suitable quantity of non-noble metal ions which adsorb at surface reaction sites. The metal ions are then reduced via chemical or electrical means. The nanostructures are exposed to a solution containing a salt of one or more noble metals which replace adsorbed non-noble surface metal atoms by galvanic displacement. The process can be controlled and repeated to obtain a desired film coverage.
    Type: Application
    Filed: October 11, 2012
    Publication date: February 21, 2013
    Applicant: Brookhaven Science Associates, LLC
    Inventor: Brookhaven Science Associates, LLC
  • Patent number: 8378329
    Abstract: Graphene magnet multilayers (GMMs) are employed to facilitate development of spintronic devices. The GMMs can include a sheet of monolayer (ML) or few-layer (FL) graphene in contact with a magnetic material, such as a ferromagnetic (FM) or an antiferromagnetic material. Electrode terminals can be disposed on the GMMs to be in electrical contact with the graphene. A magnetic field effect is induced in the graphene sheet based on an exchange magnetic field resulting from a magnetization of the magnetic material which is in contact with graphene. Electrical characteristics of the graphene can be manipulated based on the magnetization of the magnetic material in the GMM.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: February 19, 2013
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Igor Zaliznyak, Alexei Tsvelik, Dmitri Kharzeev
  • Publication number: 20130041028
    Abstract: (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid also known as CPP-115 or its pharmaceutically acceptable salts can be used to treat addiction and neurological disorders such as epilepsy without side effects such as visual field defects caused by vigabatrin (Sabril).
    Type: Application
    Filed: February 25, 2011
    Publication date: February 14, 2013
    Applicants: NORTHWESTERN UNIVERSITY, CATALYST PHARMACEUTICAL PARTNERS, INC., BROOKHAVEN SCIENCE ASSOCIATES
    Inventors: Richard B. Silverman, Stephen L. Dewey, Steven Miller
  • Publication number: 20130040343
    Abstract: The invention provides methods for enriching methyl-CpG sequences from a DNA sample. The method makes use of conversion of cytosine residues to uracil under conditions in which methyl-cytosine residues are preserved. Additional methods of the invention enable to preservation of the context of me-CpG dinucleotides. The invention also provides a recombinant, full length and substantially pure McrA protein (rMcrA) for binding and isolation of DNA fragments containing the sequence 5?-CMeCpGG-3?. Methods for making and using the rMcrA protein, and derivatives thereof are provided.
    Type: Application
    Filed: August 3, 2012
    Publication date: February 14, 2013
    Applicant: Brookhaven Science Associates, LLC
    Inventor: John J. Dunn
  • Publication number: 20130035236
    Abstract: This invention provides a method of making a fluorinated precursor of a superconducting ceramic. The method comprises providing a solution comprising a rare earth salt, an alkaline earth metal salt and a copper salt; spraying the solution onto a substrate to provide a film-covered substrate; and heating the film-covered substrate in an atmosphere containing fluorinated gas to provide the fluorinated precursor.
    Type: Application
    Filed: June 8, 2012
    Publication date: February 7, 2013
    Applicant: Brookhaven Science Associates, LLC
    Inventors: Harold Wiesmann, Vyacheslav Solovyov