Abstract: Radiotracer vorozole compounds for in vivo and in vitro assaying, studying and imaging cytochrome P450 aromatase enzymes in humans, animals, and tissues and methods for making and using the same are provided. [N-radio-methyl] vorozole substantially separated from an N-3 radio-methyl isomer of vorozole is provided. Separation is accomplished through use of chromatography resins providing multiple mechanisms of selectivity.
Type:
Application
Filed:
February 11, 2010
Publication date:
August 19, 2010
Applicant:
Brookhaven Scince Associates, LLC
Inventors:
Sung Won Kim, Anat Biegon, Joanna S. Fowler