Abstract: A nozzle assembly for forming hollow fibers, particularly a "Z-fiber" having longitudinally oriented trabeculae with the fiber wall, is provided. The nozzle assembly contains a replaceable nozzle cap, a replaceable seal-guide, and a retractable central bore used to supply core material for the hollow fibers. The Z-fibers are particularly useful in enabling cells, solutes, or the like, to enter the fiber wall and move longitudinally into the center of the fiber wall.
Type:
Grant
Filed:
September 17, 1992
Date of Patent:
January 2, 1996
Assignee:
Brown Univ. Research Foundation
Inventors:
Frank T. Gentile, Michael J. Lysaght, Nicholas F. Warner