Abstract: The size and location of microsphere uptake/delivery are important determinants of the final biodistribution of oral microsphere systems. Formulations, kits, methods of administering the formulations, and using the kits are described herein. The formulations are oral dosage formulations. In one embodiment, the formulations contain microparticles and/or nanoparticles having a homogenous size range selected to optimize uptake in a specific region of the GI tract and target drug delivery to specific organs. In some embodiments, the dosage formulation contains an enteric coating and/or a magnetic material. In a preferred embodiment, the formulation contains a magnetic material and an active agent to be delivered, optionally the active agent is in the form of micro- or nano-particles. In some embodiments metallomucoadhesive materials and/or magnetic materials are employed as magnetic and/or mucoadhesive sources.

Abstract: A system using neurological control signals to control a device is disclosed. The system may include a sensor sensing electrical activity of a plurality of neurons over time and a vector generator generating a neural control vector from the sensed electrical activity of the plurality of neurons over time. The system may also include a control filter to which the neural control vector is applied to provide a control variable and an output device controlled by the control variable.

Abstract: Optical gratings that perform a number of functions at various wavelengths are formed by various methods that preserve spectral information within a wavelength band, the functions including: coupling radiation from one waveguide to another, controllable gratings that operate on different wavelengths in response to external control signals.

Abstract: An optical component including at least one optical supergrating is provided. The optical supergrating includes a quantized refractive index profile adapted to exhibit a finite plurality of refractive indexes; which in turn are adapted to generate a reflectance spectrum in at least one spectral band corresponding to a Fourier transformed analog refractive index profile.

Abstract: An optical component including at least one optical supergrating is provided. The optical supergrating includes a quantized refractive index profile adapted to exhibit a finite plurality of refractive indexes; which in turn are adapted to generate a reflectance spectrum in at least one spectral band corresponding to a Fourier transformed analog refractive index profile.

Abstract: Optical gratings that perform a number of functions at various wavelengths are formed by various methods that preserve spectral information within a wavelength band, the functions including: coupling radiation from one waveguide to another, controllable gratings that operate on different wavelengths in response to external control signals.

Abstract: Described is a system, method and computer program product for rendering volumetric multivalued primary data. The system includes a rendering engine having an input coupled to a source of multivalued primary data and an output coupled to a display. The rendering engine includes a data processor for calculating additional data values from the primary data, deriving at least one visual representation from the primary data and the additional data values, and mapping the derived visual representation through transfer functions to hardware primitives for volumetrically rendering the derived visual representation to provide a visualization. The system further includes a user interface for interacting with the visualization.

Abstract: An optical waveguide has a surface. An array of separately actuated bodies is disposed proximal to the exposed surface, and an actuator separately actuates at least some of the bodies to change a spectral characteristic of a wave propagating through the waveguide. Preferably, the bodies are metal striplines, an electro-optical material is disposed between the striplines and the exposed surface, and the actuator is a CMOS chip that imposes a voltage to some or all of the lines. The voltage changes the refractive index at the interface with the surface, changing an index of refraction profile of the waveguide and effectively imposing a grating. Alternatively, the bodies are micro-beams and the actuator, also controlled by a CMOS chip, separately moves each micro-beam into and out of proximity to the surface. The grating is programmable via the CMOS chip.

Abstract: The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophin associated protein complex (DAPC); disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation. Examples of diseases include muscular dystrophies, such as Duchenne's Muscular Dystrophy, Becker's Muscular Dystrophy, neuromuscular disorders and neurological disorders.

Abstract: According to embodiments of the invention, one or more implants in a body may be connected with optical fibers for transmitting data and/or power to or from the implants. Aspects of the invention related to various embodiments of the actual implant as well as to various embodiments for connecting optical fibers to the implants.

Abstract: New aerogels are disclosed which comprise silica and at least one organic polymer having polar functional groups. Also disclosed are methods for making such aerogels and for making them as substantially transparent objects. In addition, gas detectors, liquid and gas absorbing objects, and optical devices made using these aerogels are disclosed. The present invention concerns optical elements which are substantially transparent and exhibit low refractive indices. The invention further relates to detectors of reactive and absorbate gases based on the physical changes exhibited by the aerogels upon reacting with or absorbing such gases. The present invention further concerns printable objects comprising these aerogels, specifically when the print media are imaged by the absorption of liquid and the spatial localization of pigments or dyes. The invention further concerns reactive gas absorbers comprising these aerogels and the catalytic function the aerogels serve to catalyze subsequent chemical reaction.

Abstract: An optical waveguide has a surface. An array of separately actuated bodies is disposed proximal to the exposed surface, and an actuator separately actuates at least some of the bodies to change a spectral characteristic of a wave propagating through the waveguide. Preferably, the bodies are metal striplines, an electro-optical material is disposed between the striplines and the exposed surface, and the actuator is a CMOS chip that imposes a voltage to some or all of the lines. The voltage changes the refractive index at the interface with the surface, changing an index of refraction profile of the waveguide and effectively imposing a grating. Alternatively, the bodies are micro-beams and the actuator, also controlled by a CMOS chip, separately moves each micro-beam into and out of proximity to the surface. The grating is programmable via the CMOS chip.

Abstract: A brain implant system consistent with embodiments of the present invention includes an electrode array having a plurality of electrodes for sensing neuron signals. A method for manufacturing the electrode array includes machining a piece of an electrically conductive substance to create a plurality of electrodes extending from a base member. Each electrode also has a corresponding base section. A nonconductive layer is provided around at least a portion of the base section of each electrode to support the plurality of electrodes. The base section of the electrodes are then cut to separate the base member from the plurality of electrodes supported by the nonconductive support layer. The present invention also includes a complete brain implant system using the above electrode array.

Abstract: A system using neurological control signals to control a device is disclosed. The system may include a sensor sensing electrical activity of a plurality of neurons over time and a vector generator generating a neural control vector from the sensed electrical activity of the plurality of neurons over time. The system may also include a control filter to which the neural control vector is applied to provide a control variable and an output device controlled by the control variable.

Abstract: New aerogels are disclosed which comprise silica, at least one organic polymer having polar functional groups, and at least one metal ion. Also disclosed are methods for making such aerogels. The present invention further concerns printable objects comprising these aerogels, specifically when the print media are imaged by the absorption of liquid and the spatial localization of pigments or dyes.

Abstract: A scanning magnetic microscope SMM (20) includes a sensor (10) for sensing a magnetic field generated by a specimen (78), the sensor including one of a MTJ, a GMR, or an EHE sensor; translation apparatus (22A–C, 52) for translating the sensor relative to a surface of sad specimen; and a data processor (50), having an input coupled to an output of said sensor, for constructing an image of said magnetic field. The sensor preferably includes one to three sensing units each defining a sensing axis for sensing a component of a magnetic field from a specimen, the sensing units disposed such that the sensing axes are orthogonal to one another. Pluralities of such sensors can be disposed in two or three dimensional arrays. The SMM can be used for examining the current flow in ICs, electromigration, magnetic data storage media, biomagnetic systems and magnetic ink used to print currency.

Abstract: Modular polyketide synthases modified so as not to incorporate natural starter units can be used for clean synthesis of novel polyketides.

Abstract: The systems and methods described herein relate to nucleic acid probes comprising a pattern of universal and designate nucleotides (or analogs thereof), or ‘gapped’ probes, and the use of sets of gapped probes in sequencing by hybridization to determine the sequence of nucleic acid sequences. The inclusion of universal nucleotides in the probes allows for efficient and rapid sequencing of longer nucleotide sequences than can be sequenced using traditional probes. The systems and methods described herein also relate to apparatus for sequencing nucleic acids which include gapped probes, as well as computer systems capable of analyzing data generated using gapped probes in such apparatus.

Abstract: The invention pertains to a human N-type calcium channel isoform, h?1B+SFVG, which is involved in central nervous system signaling, and nucleic acids relating thereto. The present invention also includes fragments and biologically functional variants of the human h?1B+SFVG channel. Also included are human N-type calcium channel h?1B+SFVG subunit inhibitors which inhibit human N-type calcium channel h?1B+SFVG subunit activity by inhibiting the expression or function of human N-type calcium channel h?1B+SFVG subunit. The invention further relates to methods of using such nucleic acids, polypeptides, and inhibitors in the treatment and/or diagnosis of disease, such as in methods for treating stroke, pain, e.g., neuropathic pain, and traumatic brain injury.

Abstract: A particle detector has a chamber defining a pathway that a target particle follows between an entry and an exit point, a solid-state energy source such as an LED, and a re-emission sensor. The energy source imparts energy to the particle between the two points, and the sensor includes an arcuate or multi-planar lens to focus energy re-emitted by the particle. The particle is identifiable by its re-emitted energy spectrum. A scanner re-directs the beam from a single energy source to track the particle between the entry and exit points. Alternatively, the energy source is a plurality of source elements that each scan the particle at a single position. Another embodiment is a chipscale detector system wherein energy source elements are disposed on a source layer, sensor elements are disposed on a sensor layer, and one or more target particles to be detected are retained on a capture layer disposed therebetween.