Abstract: An attenuated enterovirus or rhinovirus, suitable for use as a vaccine, has a reversed base pairing in the part, or in a part corresponding to the part, of the 5' non-coding region of the genome of poliovirus type 3 Leon strain shown below: ##STR1## A suitable attenuated poliovirus has the bases G and C at positions 469 and 534 respectively for a type 1 or type 2 poliovirus or at positions 472 and 537 respectively for a type 3 poliovirus.
Type:
Grant
Filed:
February 10, 1995
Date of Patent:
June 17, 1997
Assignee:
Brtish Technology Group Limited
Inventors:
Jeffrey William Almond, Philip David Minor, Michael Anthony Skinner, Colin Ruaraidh Young