Patents Assigned to Bruker Biospin AG
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Patent number: 8847595Abstract: Temperature control device (20) for an NMR sample tube (22), wherein multiple interleaved, concentric flow channels (28, 31; 40, 41, 42; 50, 51) for temperature control fluid extending coaxially with respect to a cylindrical interior space (21) for holding the NMR sample tube are constituted around said interior space (21), wherein said temperature control device is constituted such that it is closed toward the interior space in an axial end region (26) and, an axial end region (23) at the opposite end thereto, open to the interior space for inserting the NMR sample tube into said interior space (21), wherein, in a counter flow region (GB), adjacent flow channels (28, 31; 40, 41, 42; 51) are interconnected through a fluid passage (34, 43, 44) at one axial end in such a way that the direction of a fluid flow in the flow channels of the counter flow region is reversed with respect to the corresponding adjacent flow channel in the counter flow region, wherein the outermost flow channel (28; 51) of the counter flType: GrantFiled: May 10, 2011Date of Patent: September 30, 2014Assignee: Bruker BioSpin AGInventors: Beat Grossniklaus, Federico Raffa, Markus Mayer, Dirk Wilhelm
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Patent number: 8765053Abstract: A method for producing a Sn based alloy (15) comprising a metal matrix of a metal matrix material, wherein the metal matrix material comprises Sn, and inclusions of a compound material, further referred to as compound inclusions, wherein the compound material contains one element or a combination of elements of the group Ti, V, Zr, Hf, further referred to as dopant, and one or a plurality of other elements, in particular Sn, Cu and/or Nb. Particles of the metal matrix material, further referred to as matrix particles, are mixed with particles of the compound material, further referred to as compound particles, and the matrix particles and the compound particles are compacted during and/or after their mixing. A Sn based alloy containing finer compound inclusion of a dopant can be prepared, in order to produce Nb3Sn superconductor material with a superior current carrying capacity.Type: GrantFiled: January 27, 2010Date of Patent: July 1, 2014Assignee: Bruker BioSpin AGInventor: Florin Buta
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Patent number: 8729895Abstract: A method for regulating radio frequency (RF) signals in a nuclear magnetic resonance (NMR) system, comprising a spectrometer, a control loop, and an NMR probe head with RF components (BE, LE, BK), wherein the spectrometer comprises a transmitter that transmits RF signals at measuring frequencies with a transmission power (PS), the NMR probe head contains an RF oscillating circuit, and the RF oscillating circuit comprises an RF coil (LE), is characterized in that the control loop controls the duration and/or the phase and/or the power of the transmitted RF signals. Measurement of a parameter is performed by means of the NMR probe head, via which parameter the current in or the voltage across one of the RF components (BE, LE, BK) can be determined, and the transmission powers (PS) and/or the phases and/or the duration of the RF signals are regulated in dependence on the measured parameter. Any occurring losses can thereby be compensated for without reducing the pulse duration.Type: GrantFiled: December 6, 2010Date of Patent: May 20, 2014Assignee: Bruker BioSpin AGInventor: Nicolas Freytag
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Patent number: 8712489Abstract: A magnet coil configuration (20-24) is manufactured from a band-shaped conductor (1), which is slit in the longitudinal direction except for its two end areas (2, 3) such that the band-shaped conductor (1) has a first and a second half band (4, 5) and two end areas (2, 3) which connect these two half bands (4, 5) to form a closed loop. The two half-bands (4,5) of the slit band-shaped conductor (1) are initially wound onto two separate intermediate coils (14,15) and the final coil structure is subsequently wound by alternate extraction of the two half-bands (4,5) from the intermediate coils (14,15). A simple method is thereby proposed for winding a slit band-shaped conductor to form a magnet coil configuration which also generates strong magnetic fields.Type: GrantFiled: September 3, 2012Date of Patent: April 29, 2014Assignee: Bruker BioSpin AGInventors: Robert Schauwecker, Robert Herzog, Riccardo Tediosi, Matteo Alessandrini
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Patent number: 8692553Abstract: An antenna configuration for use in a magnetic resonance apparatus has at least two individual antennas which each include at least one conductor loop, one tuning network and one matching network, wherein the individual antennas are each combined into separate modules which are positioned on and mounted to a support body and can be removed therefrom in a non-destructive fashion, is characterized in that the individual antennas are connected to each other through decoupling elements, wherein the decoupling elements are mounted to the support body in an undetachable fashion. It is thereby possible to define individual antenna modules which can be arranged in a simple fashion around the measuring volume, are also electromagnetically decoupled from each other, and can be positioned close to the measuring volume in order to ensure that the received MRI image has a maximum, high signal-to-noise ratio.Type: GrantFiled: July 27, 2011Date of Patent: April 8, 2014Assignee: Bruker BioSpin AGInventor: Daniel Schmidig
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Publication number: 20140091792Abstract: A method for producing a hyperpolarized sample for use in a magnetic resonance investigation has the following steps: a) providing a solid sample (50), containing long T1 nuclei and short T1 nuclei in the same molecules (51); b) hyperpolarizing the short T1 nuclei in the solid sample (50); c) transforming the solid sample (50) into a liquid sample (52); and d) transferring the polarization of the short T1 nuclei to the long T1 nuclei within the molecules in the liquid sample (52) by Cross Polarization. The method can provide samples with hyperpolarized long T1 nuclei, in particular 13C or 15N, in a simple and efficient way.Type: ApplicationFiled: October 3, 2012Publication date: April 3, 2014Applicants: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL), BRUKER BIOSPIN AGInventors: Sami Jannin, Joost Lohman, Geoffrey Bodenhausen, Klaes Golman
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Patent number: 8633697Abstract: A method for nuclear magnetic resonance (NMR) spectroscopy of a sample involves excitation of long lived coherences (LLC) between the singlet state S0 and the central triplet state T0 of nuclei of the sample by initiating irradiation of the sample with an rf-field with carrier frequency ?rf; sustaining of the LLC by maintaining the rf-irradiation during an interval ?2; converting the LLC temporarily into observable magnetization by interrupting the rf-irradiation during an observation interval ?3; detecting NMR-signals during the observation interval ?3 and reconversion of the observable magnetization back into LLC after the observation interval ?3. These steps are repeated n times, wherein n is a positive integer. The method allows ultra high-resolution spectra of long-lived coherences to be obtained.Type: GrantFiled: May 8, 2012Date of Patent: January 21, 2014Assignees: Bruker BioSpin AG, Ecole Polytechnique Fédérale de LausanneInventors: Sami Jannin, Aurélien Bornet, Geoffrey Bodenhausen
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Patent number: 8564288Abstract: A method for sample preparation for magnetic resonance measurements using Hyperpolarization by Dissolution Dynamic Nuclear Polarization, involves preparation of frozen beads of a first kind containing paramagnetic substances in addition to the solute under investigation; insertion of the frozen beads into a polarizing magnet; creation of enhanced polarization of nuclei in a magnetic field; heating of the sample to room temperature; transfer of the sample to an MR magnet; and carrying out an MR measurement. In addition, frozen beads of a second kind containing a reducing agent are prepared and inserted into the polarization magnet together with the frozen beads of the first kind. By this method, longitudinal and transverse relaxation times in NMR are extended and free radicals in hyperpolarized solutions are eliminated.Type: GrantFiled: January 12, 2011Date of Patent: October 22, 2013Assignees: Bruker BioSpin AG, Ecole Polytechniqye Fédérale de Lausanne (EDFL)Inventors: Sami Jannin, Pascal Mieville, Geoffrey Bodenhausen
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Publication number: 20130249558Abstract: An electronic interface (10) between a pure NMR receiver resonator (RO) and a preamplifier is characterized in that one or more control diodes (Dmatch1, Dtune1) are provided by means of which the current designed to flow through the switching diodes can be fed into these switching diodes, and the control diodes are connected to the switching diodes directly or via one or more additional series impedances. In this fashion, the impedance of the resonator is transformed to the required preamplifier or line impedance during the receiving process with little loss. In particular, during the receiving process, matching can be adjusted during the transmitting process, the current in the inductance of the resonator generated by the B1 field of the transmitting resonator is minimized and all components are protected against damage.Type: ApplicationFiled: March 20, 2013Publication date: September 26, 2013Applicant: Bruker BioSpin AGInventors: Daniel Marek, Arthur Schwilch, Martin Luke
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Publication number: 20130229182Abstract: In a coil arrangement for nuclear magnetic resonance comprising a main coil (13), a shielding coil (14), and at least one correction coil (41), the function of which consists in forming a magnetic field gradient with eddy current properties which are as good as possible, the main coil (13) and the shielding coil (14) are electrically connected in series with the correction coil (41). The deviations of the residual field from the desired design generated by production tolerances are thereby modified by the correction coil in such a fashion that the long-lasting eddy currents are suppressed. This either reduces the waiting time that must lapse after a gradient pulse before a predetermined field homogeneity is achieved or e.g. the deviations from the desired field are minimized in imaging applications.Type: ApplicationFiled: February 20, 2013Publication date: September 5, 2013Applicant: BRUKER BIOSPIN AGInventors: Schimun Denoth, Silvia Buttazzoni, Thomas Speck, Dirk Wilhelm
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Patent number: 8482278Abstract: A device used in performing imaging magnetic resonance measurements (=MRI) in a Region of Interest (ROI) (9) of a small animal (3) with an MRI magnet system (7), with a cradle (5) on which the small animal (3) is lying, and with a radio-frequency (=RF) antenna (6), wherein the RF antenna (6) and the small animal (3) can be positioned relative to each other, characterized in that the device comprises a slide (1) on which the cradle together with the small animal immobilized thereupon can be moved both outside and inside the MRI magnet system, and characterized in that the RF antenna is rigidly fixed on the slide. This results in a device for the relative positioning of the small animal with respect to the RF antenna for an MRI measurement, which is easy to retrofit on existing tomography equipment, with which this positioning can be implemented both inside and outside the MRI magnet by simple handling and without great additional technical effort.Type: GrantFiled: September 22, 2009Date of Patent: July 9, 2013Assignee: Bruker BioSpin AGInventors: Dietmar Wolke, Daniel Schmidig
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Patent number: 8456165Abstract: A device has a first control loop (28) with which a frequency RF of an RF generator is synchronized with a resonance frequency F0 of an NMR line. A phase shifter (22) is provided to rotate the radio frequency phase of the NMR receiver system in the first control loop. The phase shifter is controlled by a second control loop (27) whose input signal comes from a signal extraction stage.Type: GrantFiled: April 14, 2010Date of Patent: June 4, 2013Assignee: Bruker BioSpin AGInventors: Arthur Schwilch, Michael Schenkel
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Patent number: 8456162Abstract: A method for nuclear magnetic resonance (NMR) or magnetic resonance imaging (MRI) measurements, includes creation of enhanced polarization of nuclei of a first kind within a sample in a magnetic field at cryogenic temperatures and transfer of the polarized sample to room temperature. The enhanced polarization of nuclei of the first kind is thereby transformed into long-lived states (LLS) of nuclei of a second kind and these LLS are sustained. The LLS is at least partially converted into observable magnetization and an NMR or MRI measurement is carried out. The method allows one to extend the time needed between hyperpolarized magnetization and NMR detection.Type: GrantFiled: April 30, 2010Date of Patent: June 4, 2013Assignees: Bruker BioSpin AG, Ecole Polytechnique Fédérale de Lausanne (EPFL)Inventors: Paul Romeo Vasos, Arnaud Comment, Riddhiman Sarkar, Sami Antoine Jannin, Geoffrey Bodenhausen
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Patent number: 8372784Abstract: A method for producing a superconductive wire, whereby an elongated intermediate element is formed out of an initial element in a deformation step and whereby the superconductive filaments are formed by a final reaction heat treatment, is characterized in that prior to the final reaction heat treatment the filaments in the intermediate element are densified in one or more high pressure densification steps following up the deformation step, said densification steps comprising a simultaneous action of at least four hard surfaces perpendicular to the axis of the elongated intermediate element, building up high pressure P?100 MPa on a part of the intermediate element having an axial length L. This leads to a substantial increase of the critical current density Jc, whereby the anisotropy factor ? is be almost not affected thus enabling production of almost isotropic wires or tapes.Type: GrantFiled: September 29, 2009Date of Patent: February 12, 2013Assignee: Bruker Biospin AGInventor: René Flükiger
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Patent number: 8362770Abstract: A method for nuclear magnetic resonance (NMR) spectroscopy of a sample comprises preparation of the sample and carrying out an NMR spectroscopy measurement. Preparation includes excitation of long lived coherences (LLC) between the singlet state S0 and the central triplet state T0 of nuclei of the sample. The thermal equilibrium Boltzmann distribution (Iz+Sz) is thereby transformed into a difference (Iz?Sz), which is flipped to the transverse plane, and irradiation of the sample with an rf-field is initiated. The LLC is sustained by maintaining the rf-irradiation during an interval t1 and the LLC is converted into observable magnetisation by interrupting the rf-irradiation. The method allows nuclear magnetic resonance spectroscopy measurements with improved spectral resolution.Type: GrantFiled: April 30, 2010Date of Patent: January 29, 2013Assignees: Bruker BioSpin AG, Ecole Polytechnique Fédérale de LausanneInventors: Paul Romeo Vasos, Riddhiman Sarkar, Puneet Ahuja, Geoffrey Bodenhausen
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Patent number: 8312781Abstract: A sample frame (30; 81) for preparing a plurality of sample vessels (41, 42), in particular sample tubes, having a plurality of retainers, in each of which a sample vessel (41, 42) is situated, is characterized in that the sample vessels (41, 42) each have a cap (43, 44), which is put over the open end of the sample vessel (41, 42), the cap (41, 42) having a drilled hole (53, 54), through which the interior of the sample vessel (41, 42) is accessible, the sample frame (30; 81) has a removable cover plate (8), whose bottom side faces toward the caps (43, 44) of the sample vessels (41, 42) in the put-on state of the cover plate (8), and the cover plate (8) has an approximately funnel-shaped depression (11, 71) on the top side for each retainer, in whose center a through opening (57) through the cover plate (8) is provided, the through opening (57) aligning with the drilled hole (53, 54) of a cap (43, 44) of a sample vessel (41, 42) retained underneath when the cover plate (8) is put on.Type: GrantFiled: February 17, 2009Date of Patent: November 20, 2012Assignee: Bruker BioSpin AGInventors: Kurt Himmelsbach, Beat Grossniklaus
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Patent number: 8299792Abstract: A device for monitoring a living object during a magnetic resonance (MRI) experiment in an MRI tomograph, wherein the device comprises one or more individual electrodes which are connected in an electrically conducting fashion to the living object to be examined, and are connected to a monitoring device via signal lines, wherein each signal line comprises individual parts that are electrically connected to each other via impedances. The eigenfrequencies of these parts are higher than the NMR measuring frequency, preferably more than twice as high, and the parts are electrically connected to each other via frequency-dependent impedances Zn. The electro-magnetic coupling from the RF antenna and the gradient coils to the signal lines can thereby also be minimized in a simple fashion.Type: GrantFiled: March 2, 2010Date of Patent: October 30, 2012Assignee: Bruker Biospin AGInventor: Daniel Schmidig
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Patent number: 8250020Abstract: A fully automatic, parameter free MR interpretation system is based on human logic emulation. Information is derived mainly from an MR spectrum with maximum confidence and in a similar way as a human expert. This is achieved by the combination of different expert systems that interpret certain MR spectral features as well as features from a proposed structure. The expert systems are dynamically linked to each other and the analysis is performed iteratively in all directions in a way that the expert systems can utilize all of the interpretations of all expert systems at all times. The expert system may generate not just a single result but rather lists of probability weighted hypotheses.Type: GrantFiled: August 26, 2009Date of Patent: August 21, 2012Assignees: Bruker Biospin AG, Universitaet ZuerichInventors: Jiwen Li, Abraham Bernstein, Bjoern Heitmann, Michael Fey, Till Kuehn, Sandra Loss, James Masse, Konstantin Pervushin, Oskar Schett
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Patent number: 8217655Abstract: A transport device for conveying an object to be transported (18) between an input point (A) and a supply point (Z), where the object to be transported (18) can be supplied to an RT tube (4) of a cryostat (1), wherein the input point (A) is both horizontally and also vertically spaced apart from the supply point (Z), wherein a transport tube (14) is provided for pneumatically conveying the object to be transported within the transport tube (14) from a first transfer point (B) to a second transfer point (C), is characterized in that the transport tube (14) is vertically arranged, a first transport container (TB1) and a second transport container (TB2) are provided for receiving the object to be transported (18), a first transfer device is disposed between the input point (A) and the first transfer point (B), and a second transfer device is provided between the second transfer point (C) and the supply point (Z).Type: GrantFiled: December 15, 2009Date of Patent: July 10, 2012Assignee: Bruker BioSpin AGInventors: Jonathan De Vries, Daniel Guy Baumann, Oskar Schett, Werner Maas
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Patent number: 8154292Abstract: An apparatus for DNP-NMR measurement on a sample, with a magnet configuration for producing a magnetic field in a first working volume and in, a second working volume with a magnetic field gradient in the direction of an axis (z) which extends through the second working volume, with a device for measuring MR signals, with a DNP excitation device, and with a positioning mechanism for transferring the sample, is characterized in that, near the second working volume, a compensation configuration made of magnetic material is mounted that, in the operating condition of the magnet configuration, produces a magnetic field gradient in the direction of the axis (z) in the second working volume that is between ?90% and ?110% of the magnetic field gradient of the same order of the stray field of the magnet configuration.Type: GrantFiled: July 14, 2009Date of Patent: April 10, 2012Assignee: Bruker BioSpin AGInventors: Pierre-Alain Bovier, Robert Schauwecker, Daniel Eckert