Patents Assigned to Bruker BioSpin MRI GmbH
  • Patent number: 10901056
    Abstract: A hybrid imaging apparatus includes a magnetic resonance imaging (MM) arrangement having an RF resonator structure (1) and a gradient coil system (8) having a longitudinal axis, an emission tomography (ET) arrangement with a detector device having at least one photosensor (3) and one circuit board arrangement with at least one readout circuit board (11) on which an ET electronics is arranged, and an internal shielding device (7) shielding the readout electronics (4) of the ET arrangement and shielding the RF resonator structure of the MRI arrangement. The photosensor is arranged, in relation to the longitudinal axis, radially inside the sensor circuit boards and radially outside the RF resonator structure. The internal shielding device is arranged radially outside the photosensor and/or integrated into the photosensor. This achieves both a compact design and optimized performance of the detection of the MR and ET imaging.
    Type: Grant
    Filed: July 9, 2019
    Date of Patent: January 26, 2021
    Assignee: BRUKER BIOSPIN MRI GMBH
    Inventors: Arne Berneking, Sven Junge
  • Patent number: 10796465
    Abstract: A method for establishing and/or reducing artifacts that arise when reconstructing (R) an MPI overall image data record from MPI signal data and an appended system matrix (SMapp(r,f)), wherein the appended system matrix (SMapp(r,f)) includes system matrices of different particle classes (P1, P2). The method includes setting a selection region (cvn(r)) of a reconstructed MPI overall image data record (cn(r)), producing virtual signal data (sn(f)) by inverse transformation of the selection region, reconstructing a virtual overall image data record (c?vn(r)) from the virtual signal data and the appended system matrix, setting an artifact region (cartifact_n(r)) within the reconstructed virtual overall image data record so that the artifact region has only voxels lying outside of the selection region, and assigning the image data present in the artifact region as artifact image data (cartifact_n(r)). This permits ghost artifacts to be corrected.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: October 6, 2020
    Assignee: BRUKER BIOSPIN MRI GMBH
    Inventors: Jochen Franke, Michael Herbst
  • Patent number: 10782367
    Abstract: A method for establishing a local concentration distribution of magnetic particles of at least one particle class within an examination volume or a variable derived from this concentration distribution. The method includes providing at least one system matrix, providing MPI signal data of at least one sample including magnetic particles of at least one particle class within a measurement volume, and reconstructing spatially resolved MPI image data from the provided MPI signal data. At least one spatial projection of at least one part of the system matrix is carried out along a projection direction and a projected system matrix is generated thereby. The reconstruction of the MPI image data is implemented with the at least partly projected system matrix, as a result of which MPI image data of a spatial projection of the local concentration distribution of the magnetic particles are produced along the projection direction.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: September 22, 2020
    Assignee: BRUKER BIOSPIN MRI GMBH
    Inventors: Jochen Franke, Michael Herbst
  • Patent number: 10473741
    Abstract: A method to generate an attenuation correction map to compensate imaging errors in emission tomography resulting from the presence of hardware parts inside the imaging volume of an emission tomograph. Components of 3-dimensional CAD models of the hardware parts to be compensated are converted into voxels on a predetermined grid and assigned a filling factor per voxel. Image data sets of each component are multiplied with respective attenuation coefficients and thereafter superimposed to form an attenuation correction map. Thereby, in a simple and automatable way a profoundly exact, mostly noise-free and exactly reproducible attenuation correction map for attenuation correction in an emission tomography device may be generated.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: November 12, 2019
    Assignee: BRUKER BIOSPIN MRI GMBH
    Inventors: Sven Junge, Thimo Hugger
  • Patent number: 10215826
    Abstract: An MPI-apparatus comprising a magnet system for generating a time-varying and position-dependent magnetic field and a detection system detecting signals from MPI contrast agents exposed to said magnetic field within a detection volume, said signals being suitable for reconstructing an image of the spatial and temporal distribution of said MPI contrast agents, is characterized in that the magnet system comprises an array with a plurality of permanent magnetic elements geometrically arranged in such a way that at least a part of the plurality of permanent magnetic elements are moved with sufficient speed in the vicinity of the detection volume to create the spatial and temporal magnetic field variations for inducing within the contrast agent the MPI signals recorded by the detection system. This avoids the high power requirements of current MPI scanners, while opening the way for higher spatial resolutions and variable scanning frequencies.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: February 26, 2019
    Assignee: Bruker BioSpin MRI GmbH
    Inventors: Ulrich Heinen, Jochen Franke
  • Patent number: 10191130
    Abstract: A device for alternating examination of a measurement object (170) by means of MPI and MRI with two magnetic field-generating elements is presented. The device is characterized by a main magnet coil system with two coaxial partial coil systems (100a1, 100a2; 100b2, 100b1) arranged mirror-symmetrically relative to a central plane running perpendicularly to the z-axis through the first volume under investigation (162). The volumes under investigation are superimposed. A polarity reversal device (190) reverses the polarity of the current through a partial coil system and the main magnet coil system generates a homogeneous magnetic field of at least sixth order in the first volume under investigation when the partial coil systems have identical polarity, and a spatially strongly varying magnetic field profile in the second volume under investigation when the polarities are opposite. Repositioning of the measurement object is thereby simplified or can even be eliminated.
    Type: Grant
    Filed: November 22, 2013
    Date of Patent: January 29, 2019
    Assignee: BRUKER BIOSPIN MRI GMBH
    Inventors: Michael Heidenreich, Jochen Franke, Volker Niemann, Rainer Pietig
  • Patent number: 10172587
    Abstract: A phantom system has a housing (2) with a lower part (3) having an opening in the z-direction and a cover part (4) for closing the opening of the housing (2). A first plate-shaped insert element (10a) has at least one depression (11a) for receiving a liquid substance. The lower part (3) and the cover part (4) delimit a cavity (5) with an insert area (8), which is constituted to receive the first insert element (10a). A first sealing element (14a) seals the first insert element (10a) against the cavity (5) and a fixing facility fixes the first insert element (10a) in the cavity (4) of the housing (2) in an operating state of the MPI phantom. The phantom permits good contrast in MPI, MRI, or ?CT using liquid contrast media.
    Type: Grant
    Filed: March 15, 2016
    Date of Patent: January 8, 2019
    Assignee: Bruker BioSpin MRI GmbH
    Inventors: Jochen Franke, Ulrich Heinen
  • Patent number: 10016146
    Abstract: An MPI method determines calibration and measurement volumes, wherein the calibration volume is larger than the measurement volume and the overall measurement volume is arranged within the calibration volume. Calibration signals are detected and a system matrix S is created. An MPI measuring signal u is recorded, a location-dependent magnetic particle concentration c with magnetic particle concentration values ci within the calibration volume is reconstructed and the magnetic particle concentration values ci are associated with voxels in the calibration volume. Magnetic particle concentration values ci which were associated with voxels outside of the measurement volume are discarded and an MPI image is generated which exclusively contains magnetic particle concentration values ci which were associated with the voxels within the measurement volume. MPI image data are thereby generated with little artifacts within a short time even in case of high magnetic particle densities outside of the measurement volume.
    Type: Grant
    Filed: July 13, 2016
    Date of Patent: July 10, 2018
    Assignee: Bruker BioSpin MRI GmbH
    Inventor: Alexander Weber
  • Patent number: 9965874
    Abstract: A calibration method for an MPI (=magnetic particle imaging) apparatus for conducting an MPI experiment, wherein the calibration method comprises m calibration MPI measurements with a calibration test piece and uses these measurements to create an image reconstruction matrix with which the signal contributions of N voxels within an investigation volume of the MPI apparatus are determined, wherein compressed sensing steps are applied in the calibration method with a transformation matrix that sparsifies the image construction matrix, and wherein only a number M<N of calibration MPI measurements for M voxels are carried out, from which the image reconstruction matrix is created and stored. This specifies an efficient method for determination of the system matrix for the MPI imaging method, which does not require much time to determine an MPI system function and nevertheless achieves a high degree of precision.
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: May 8, 2018
    Assignee: Bruker BioSpin MRI GmbH
    Inventor: Tobias Knopp
  • Patent number: 9958522
    Abstract: A method for determining the spatial distribution of magnetic resonance signals from at least one of N subvolumes predefines a reception encoding scheme and determines unique spatial encoding for at least one of the subvolumes but not for the entire volume under examination (UV). A transmission encoding scheme is also defined, wherein encoding is effected via the amplitude and/or phase of the transverse magnetization. The temporal amplitude and phase profile of the RF pulses is then calculated and each reception encoding step is carried out I times with variations according to the I transmission encoding steps in the transmission encoding scheme. The method makes it possible to largely restrict the spatially resolving MR signal encoding and image reconstruction to subvolumes of the object under examination without the achievable image quality sensitively depending on imperfections in the MR apparatus.
    Type: Grant
    Filed: April 18, 2012
    Date of Patent: May 1, 2018
    Assignee: Bruker BioSpin MRI GmbH
    Inventors: Wolfgang Ruhm, Johannes Schneider, Peter Ullmann
  • Patent number: 9927500
    Abstract: Device for alternating examination of a measurement object (103) by means of MPI and MRI within a magnetic system is characterized in that the magnetic system has a specified magnetic field profile, which is not temporally variable during the alternating examination, and both magnetic field generating elements (101,102; 201,202; 801a,801b,811,812) generate a magnetic field portion, in the first examination region (104) and in the second examination region (105), which is essential for the MRI operation and for the MPI operation, and in that there is a transport apparatus (106) by means of which the measurement object can be moved out of the first examination region and into the second examination region and/or vice versa. The total space requirement for both modalities is thus reduced and the complexity of an integrally designed hybrid system is minimized.
    Type: Grant
    Filed: August 16, 2013
    Date of Patent: March 27, 2018
    Assignee: Bruker BioSpin MRI GmbH
    Inventors: Michael Heidenreich, Jochen Franke, Volker Niemann, Rainer Pietig
  • Patent number: 9885768
    Abstract: A method for generating a desired temporal profile of the magnetization state in an object under examination (O) during an experiment involving magnetic resonance is characterized in that at least one spatially dependent change in the magnetization state inside the object under examination (O) is predefined and spatially selective radio-frequency pulses, which allow a simultaneous and independent change in the magnetization state at locations with different stipulations, are irradiated in order to implement the predefined spatially dependent change in the magnetization state. The method permits establishment of the same desired temporal profile of the magnetization state for different regions of the object under examination despite different given experimental parameters or deliberate generation of different desired profiles of the magnetization state at different locations.
    Type: Grant
    Filed: April 18, 2012
    Date of Patent: February 6, 2018
    Assignee: Bruker BioSpin MRI GmbH
    Inventors: Peter Ullmann, Johannes Schneider, Wolfgang Ruhm
  • Patent number: 9869738
    Abstract: A method for determining the position of at least one ferromagnetic particle (30) in a liquid matrix (31) with an MRI system (50). An MRI measurement sequence (MS1, MS2) is applied (20) to a measurement volume (52) in which the particle is situated. The measurement sequence includes a plurality of individual measurements (E1, E2), during each of which there is a spatially encoding gradient switching operation, including an excitation pulse (1) and signal recording (2), via the MRI system. The measurement sequence has a multiplicity of measurement blocks (MB1, MB2), which each include one or more individual measurements and, in a pause of the spatial encoding, an intermediate gradient (ZW) switched by the MRI system. The intermediate gradients are dimensioned such that, averaged over time, the particle is kept substantially in the same position (M1, M2) over each measurement block.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: January 16, 2018
    Assignee: Bruker BioSpin MRI GmbH
    Inventor: Arno Nauerth
  • Patent number: 9689946
    Abstract: A method for magnetic resonance (MR) for imaging an imaging area of an object has a reconstruction image quality which depends on a spatial distribution of background phase. A background phase distribution is initially determined using an optimization algorithm having a reconstruction quality as an optimization criterion, wherein limitation of a spatial variation of a background phase offset distribution is integrated as a boundary condition in the optimization algorithm. At least one spatially selective radio frequency pulse is applied which contributes to generation of an MR signal distribution having a previously determined background phase distribution, wherein the at least one spatially selective radio frequency pulse generates the background phase offset distribution as a part of the background phase distribution. In this fashion, the reconstruction quality is improved in a manner which can be realized using available equipment.
    Type: Grant
    Filed: April 16, 2013
    Date of Patent: June 27, 2017
    Assignee: Bruker BioSpin MRI GmbH
    Inventors: Johannes Schneider, Peter Ullmann
  • Patent number: 9651637
    Abstract: A method related to Magnetic Particle Imaging (MPI) includes a signal processing step in which MPI time signals are acquired and successive acquisition cycles are completed within one scanning period. From the scanning period, an image acquisition period is selected for which a composite time signal is generated by concatenating measured values acquired in immediate succession. A corrected time signal is determined from the composite time signal by windowing, performing a Fourier transform, and reducing a number of frequency values by eliminating intermediate frequencies of the Fourier transform of the windowed, composite time signal. In a reconstruction step, a spatial assignment and/or distribution of the magnetic particles is computed, and in an outputting step, the results of the reconstruction and/or one or more parameters derived therefrom are stored and/or displayed.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: May 16, 2017
    Assignee: Bruker BioSpin MRI GmbH
    Inventors: Alexander Weber, Ulrich Heinen
  • Publication number: 20150221103
    Abstract: A calibration method for an MPI (=magnetic particle imaging) apparatus for conducting an MPI experiment, wherein the calibration method comprises m calibration MPI measurements with a calibration test piece and uses these measurements to create an image reconstruction matrix with which the signal contributions of N voxels within an investigation volume of the MPI apparatus are determined, wherein compressed sensing steps are applied in the calibration method with a transformation matrix that sparsifies the image construction matrix, and wherein only a number M<N of calibration MPI measurements for M voxels are carried out, from which the image reconstruction matrix is created and stored. This specifies an efficient method for determination of the system matrix for the MPI imaging method, which does not require much time to determine an MPI system function and nevertheless achieves a high degree of precision.
    Type: Application
    Filed: November 14, 2012
    Publication date: August 6, 2015
    Applicant: BRUKER BIOSPIN MRI GMBH
    Inventor: Tobias Knopp
  • Publication number: 20150084627
    Abstract: A method for determining the spatial distribution of magnetic resonance signals from at least one of N subvolumes predefines a reception encoding scheme and determines unique spatial encoding for at least one of the subvolumes but not for the entire volume under examination (UV). A transmission encoding scheme is also defined, wherein encoding is effected via the amplitude and/or phase of the transverse magnetization. The temporal amplitude and phase profile of the RF pulses is then calculated and each reception encoding step is carried out I times with variations according to the I transmission encoding steps in the transmission encoding scheme. The method makes it possible to largely restrict the spatially resolving MR signal encoding and image reconstruction to subvolumes of the object under examination without the achievable image quality sensitively depending on imperfections in the MR apparatus.
    Type: Application
    Filed: April 18, 2012
    Publication date: March 26, 2015
    Applicant: BRUKER BIOSPIN MRI GMBH
    Inventors: Wofgang Ruhm, Johannes Schneider, Peter Ullmann
  • Publication number: 20140312898
    Abstract: A method for generating a desired temporal profile of the magnetization state in an object under examination (O) during an experiment involving magnetic resonance is characterized in that at least one spatially dependent change in the magnetization state inside the object under examination (O) is predefined and spatially selective radio-frequency pulses, which allow a simultaneous and independent change in the magnetization state at locations with different stipulations, are irradiated in order to implement the predefined spatially dependent change in the magnetization state. The method permits establishment of the same desired temporal profile of the magnetization state for different regions of the object under examination despite different given experimental parameters or deliberate generation of different desired profiles of the magnetization state at different locations.
    Type: Application
    Filed: April 18, 2012
    Publication date: October 23, 2014
    Applicant: BRUKER BIOSPIN MRI GMBH
    Inventors: Peter Ullmann, Johannes Schneider, Wolfgang Ruhm
  • Patent number: 8633696
    Abstract: A method for designing the time dependence function km(t) for a given k-space trajectory km, where m stands for one or multiple of the spatial dimension indices x, y, or z, of a magnetic resonance imaging (=MRI) experiment carried out on an MRI system, wherein the trajectory km is generated by applying a time varying waveform gm(t) of a gradient magnetic field, the method taking into account—the gradient magnitude limit G and—the gradient slew rate limit S of the MRI system, is characterized in that the method further takes into account a given frequency limit F in such a way that the gradient waveform gm(t) does not contain frequency components above the frequency limit F which is characteristic for the gradient hardware of the MRI system. The invention provides a method for designing a time dependence function for a given k-space trajectory, which allows obtaining better quality MRI images.
    Type: Grant
    Filed: March 16, 2011
    Date of Patent: January 21, 2014
    Assignee: Bruker BioSpin MRI GmbH
    Inventors: Markus Weiger Senften, Thomas Oberhammer, Franciszek Hennel
  • Patent number: 8508224
    Abstract: A method for obtaining amplitude and phase dependencies of radio frequency pulses, which are irradiated within the scope of a main magnetic resonance experiment for generating a predetermined n-dimensional spatial distribution (n>=1) of transverse magnetization in an object by means of at least one radio frequency transmitting antenna of a magnetic resonance measuring system in combination with spatially and temporally varying additional magnetic fields which are superimposed on the static and homogeneous base field of the magnetic resonance measuring system and change the transverse magnetization phase in the object in dependence on location and time is characterized in that, prior to performance of the main experiment, a preparational measurement is performed in which the change with time of the transverse magnetization phase in the object under the action of the additional magnetic fields is measured in a position-resolved fashion and the amplitude and phase dependencies of the radio frequency pulses fo
    Type: Grant
    Filed: March 25, 2010
    Date of Patent: August 13, 2013
    Assignee: Bruker BioSpin MRI GmbH
    Inventors: Johannes Schneider, Peter Ullmann