Abstract: A pressure relief device for a sealed system is provided. The device includes a negative pressure support that is engageable with the system. A seal is disposed between the support and the system such that a negative pressure differential created in the system acts on the seal to move the seal away from the negative pressure support. A wire connects the seal to the support. The wire is configured to break, thereby releasing the seal, when the seal is exposed to a negative pressure differential having a predetermined level. The device may also include a positive pressure support disposed between the seal and the negative pressure support. The positive pressure support prevents the seal from releasing until the system experiences a positive pressure differential of a predetermined level. The device may also include a sensor that indicates when the seal has released.