Patents Assigned to BTG International Ltd.
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Patent number: 10472100Abstract: A therapeutic foam for the treatment of, inter alia, varicose veins comprises a sclerosing solution foamed with a physiological gas such as carbon dioxide, oxygen or a mixture thereof. The foam has a nitrogen content of less than 0.8%. It may be generated using a pressurized canister system incorporating a fine mesh of micron dimensions through which the gas and sclerosing liquid are passed to make the foam. Alternatively, the foam may be generated by passing gas and solution between two syringes through a fine mesh. Techniques are described for minimizing the amount of nitrogen in a canister or syringe based product. A technique for generating and delivering foam simultaneously using a syringe based device is also disclosed.Type: GrantFiled: May 8, 2015Date of Patent: November 12, 2019Assignee: BTG International Ltd.Inventors: David Dakin Iorwerth Wright, Anthony David Harman, Nikki Robinson, Garry Hodges, Adil Kadar, Geoffrey D. Moggridge, Hugh Van Liew
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Publication number: 20140221501Abstract: A therapeutic foam for the treatment of, inter alia, varicose veins comprises a sclerosing solution foamed with a physiological gas such as carbon dioxide, oxygen or a mixture thereof. The foam has a nitrogen content of less than 0.8%. It may be generated using a pressurised canister system incorporating a fine mesh of micron dimensions through which the gas and sclerosing liquid are passed to make the foam. Alternatively, the foam may be generated by passing gas and solution between two syringes through a fine mesh. Techniques are described for minimising the amount of nitrogen in a canister or syringe based product. A technique for generating and delivering foam simultaneously using a syringe based device is also disclosed.Type: ApplicationFiled: April 9, 2014Publication date: August 7, 2014Applicant: BTG International Ltd.Inventors: David Dakin Iorwerth WRIGHT, Anthony David HARMAN, Nikki ROBINSON, Garry HODGES, Adil KADAR, Geoffrey D. MOGGRIDGE, Hugh VAN LIEW
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Patent number: 8734833Abstract: A therapeutic foam for the treatment of, inter alia, varicose veins comprises a sclerosing solution foamed with a physiological gas such as carbon dioxide, oxygen or a mixture thereof. The foam has a nitrogen content of less than 0.8%. It may be generated using a pressurized canister system incorporating a fine mesh of micron dimensions through which the gas and sclerosing liquid are passed to make the foam. Alternatively, the foam may be generated by passing gas and solution between two syringes through a fine mesh. Techniques are described for minimizing the amount of nitrogen in a canister or syringe based product. A technique for generating and delivering foam simultaneously using a syringe based device is also disclosed.Type: GrantFiled: November 2, 2012Date of Patent: May 27, 2014Assignee: BTG International Ltd.Inventors: David Dakin Iorwerth Wright, Anthony David Harman, Nikki Robinson, Garry Hodges, Adil Kadar, Geoffrey D. Moggridge, Hugh Van Liew
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Patent number: 8703827Abstract: A foam for the treatment of varicose veins is disclosed, comprising a sclersosant solution, e.g. polidocanol, foamed with a gas mixture which includes greater than 41% of a lipid soluble gas such as xenon. The aim is to provide a foam which may be injected into a varicose vein in large quantities because the gas component is dissipated quickly after the foam has acted on the varicose vein.Type: GrantFiled: May 12, 2006Date of Patent: April 22, 2014Assignee: BTG International Ltd.Inventor: William John Jenkins
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Patent number: 8517975Abstract: A device and a method for generating therapeutic foam from a sclerosing solution such as polidocanol and a gas which is absorbable or dissolvable in the body comprises a disposable cassette including a liquid container and a flexible chamber containing gas, chamber being formed as a loop. Located in the loop chamber is a foam generating mesh. In use, liquid is introduced into the chamber and then the cassette is inserted into a pumping machine where it is engaged by a peristaltic pump which circulates the contents of the loop chamber through the mesh, thus creating foam. When a steady state is reached, foam may be withdrawn using a syringe via either a port or septum.Type: GrantFiled: July 9, 2012Date of Patent: August 27, 2013Assignee: BTG International Ltd.Inventors: David Dakin Iorwerth Wright, Anthony David Harman, Garry Hodges, David John Targell, Mark Simpson Yeoman, Jeremy Francis Donnan
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Patent number: 8512680Abstract: The placing of a drug that is suitable for parenteral administration on bubbles formed with sterile gases produces an exponential increase in its active surface area with a decrease in the diameter of the bubble, modifies the kinetics of its distribution and, thanks to its micronization, increases its therapeutic effect. Furthermore, the echogenicity of the bubbles allows us to follow them on ultrasound after their injection, so that we can visualise the medicament and, thanks to its steerability, can direct it to the selected site or prevent it from reaching undesired areas. This pharmaceutical form is of interest in the treatment of diseases that require a greater local action of the injected drugs than can be achieved with the pharmaceutical forms in current use.Type: GrantFiled: July 16, 2007Date of Patent: August 20, 2013Assignee: BTG International Ltd.Inventor: María Antonia García-Olmedo Dominguez
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Publication number: 20130059923Abstract: A therapeutic foam for the treatment of, inter alia, varicose veins comprises a sclerosing solution foamed with a physiological gas such as carbon dioxide, oxygen or a mixture thereof. The foam has a nitrogen content of less than 0.8%. It may be generated using a pressurised canister system incorporating a fine mesh of micron dimensions through which the gas and sclerosing liquid are passed to make the foam. Alternatively, the foam may be generated by passing gas and solution between two syringes through a fine mesh. Techniques are described for minimising the amount of nitrogen in a canister or syringe based product. A technique for generating and delivering foam simultaneously using a syringe based device is also disclosed.Type: ApplicationFiled: November 2, 2012Publication date: March 7, 2013Applicant: BTG INTERNATIONAL LTD.Inventors: David Dakin Iorwerth Wright, Anthony David Harman, Nikki Robinson, Garry Hodges, SR., Adil Kadar, Geoffrey D. Moggridge, Hugh Van Liew
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Patent number: 8323677Abstract: A therapeutic foam for the treatment of, inter alia, varicose veins comprises a sclerosing solution foamed with a physiological gas such as carbon dioxide, oxygen or a mixture thereof. The foam has a nitrogen content of less than 0.8%. It may be generated using a pressurized canister system incorporating a fine mesh of micron dimensions through which the gas and sclerosing liquid are passed to make the foam. Alternatively, the foam may be generated by passing gas and solution between two syringes through a fine mesh. Techniques are described for minimizing the amount of nitrogen in a canister or syringe based product. A technique for generating and delivering foam simultaneously using a syringe based device is also disclosed.Type: GrantFiled: April 23, 2010Date of Patent: December 4, 2012Assignee: BTG International Ltd.Inventors: David Dakin Iorwerth Wright, Anthony David Harman, Nikki Robinson, Garry Hodges, Adil Kadar, Geoffrey D. Moggridge, Hugh Van Liew
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Patent number: 8235935Abstract: A device and a method for generating therapeutic foam from a sclerosing solution such as polidocanol and a gas which is absorbable or dissolvable in the body comprises a disposable cassette including a liquid container and a flexible chamber containing gas, chamber being formed as a loop. Located in the loop chamber is a foam generating mesh. In use, liquid is introduced into the chamber and then the cassette is inserted into a pumping machine where it is engaged by a peristaltic pump which circulates the contents of the loop chamber through the mesh, thus creating foam. When a steady state is reached, foam may be withdrawn using a syringe via either a port or septum.Type: GrantFiled: December 21, 2007Date of Patent: August 7, 2012Assignee: BTG International, LtdInventors: David Dakin Iorwerth Wright, Anthony David Harman, Garry Hodges, David John Targell, Mark Simpson Yeoman, Jeremy Francis Donnan
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Publication number: 20110275640Abstract: The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general formula (I) below or a pharmacologically permitted salt thereof; and also to nitrogen-containing heteroaryl derivatives having specific substituents, or pharmacologically permitted salts thereof, which are valuable as preventives or remedies for Alzheimer's disease, or as amyloid protein fibril-formation inhibitors: (where, R1 and R2 are H or alkyl; Z1 and Z2 are H, alkyl, alkoxy, haloalkyl or halogeno; Z3 is alkoxy, SH, alkylthio, NH2, mono- or di-alkylamino, OH or halogeno; Z4 and Z5 are H or halogeno; and A is 4,6-pyrimidine-1,3-diyl, 1,3,5-triazine-2,6-diyl, etc).Type: ApplicationFiled: May 10, 2011Publication date: November 10, 2011Applicant: BTG International Ltd.Inventors: Masaki Meguro, Tomiichiro Oda, Yasuhiro Nakagami, Shinji Marumoto, Kazuo Koyama, Isao Kaneko
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Publication number: 20110275641Abstract: The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general formula (I) below or a pharmacologically permitted salt thereof; and also to nitrogen-containing heteroaryl derivatives having specific substituents, or pharmacologically permitted salts thereof, which are valuable as preventives or remedies for Alzheimer's disease, or as amyloid protein fibril-formation inhibitors: (where, R1 and R2 are H or alkyl; Z1 and Z2 are H, alkyl, alkoxy, haloalkyl or halogeno; Z3 is alkoxy, SH, alkylthio, NH2, mono- or di-alkylamino, OH or halogeno; Z4 and Z5 are H or halogeno; and A is 4,6-pyrimidine-1,3-diyl, 1,3,5-triazine-2,6-diyl, etc).Type: ApplicationFiled: May 10, 2011Publication date: November 10, 2011Applicant: BTG International Ltd.Inventors: Masaki Meguro, Tomiichiro Oda, Yasuhiro Nakagami, Shinji Marumoto, Kazuo Koyama, Isao Kaneko
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Patent number: 8048439Abstract: A therapeutic foam for the treatment of, inter alia, varicose veins comprises a sclerosing solution foamed with a physiological gas such as carbon dioxide, oxygen or a mixture thereof. The foam has a nitrogen content of less than 0.8%. It may be generated using a pressurized canister system incorporating a fine mesh of micron dimensions through which the gas and sclerosing liquid are passed to make the foam. Alternatively, the foam may be generated by passing gas and solution between two syringes through a fine mesh. Techniques are described for minimizing the amount of nitrogen in a canister or syringe based product. A technique for generating and delivering foam simultaneously using a syringe based device is also disclosed.Type: GrantFiled: May 13, 2005Date of Patent: November 1, 2011Assignee: BTG International Ltd.Inventors: David Dakin Iorwerth Wright, Anthony David Harman, Nikki Robinson, Garry Hodges, Adil Kadar, Geoffrey D. Moggridge, Hugh Van Liew, William John Jenkins
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Patent number: 8003645Abstract: The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general formula (I) below or a pharmacologically permitted salt thereof; and also to nitrogen-containing heteroaryl derivatives having specific substituents, or pharmacologically permitted salts thereof, which are valuable as preventives or remedies for Alzheimer's disease, or as amyloid protein fibril-formation inhibitors: (where, R1 and R2 are H or alkyl; Z1 and Z2 are H, alkyl, alkoxy, haloalkyl or halogeno; Z3 is alkoxy, SH, alkylthio, NH2, mono- or di-alkylamino, OH or halogeno; Z4 and Z5 are H or halogeno; and A is 4,6-pyrimidine-1,3-diyl, 1,3,5-triazine-2,6-diyl, etc).Type: GrantFiled: February 6, 2008Date of Patent: August 23, 2011Assignee: BTG International Ltd.Inventors: Masaki Meguro, Tomichiro Oda, Yasuhiro Nakagami, Shinji Marumoto, Kazuo Koyama, Isao Kaneko
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Publication number: 20100203171Abstract: A therapeutic foam for the treatment of, inter alia, varicose veins comprises a sclerosing solution foamed with a physiological gas such as carbon dioxide, oxygen or a mixture thereof. The foam has a nitrogen content of less than 0.8%. It may be generated using a pressurised canister system incorporating a fine mesh of micron dimensions through which the gas and sclerosing liquid are passed to make the foam. Alternatively, the foam may be generated by passing gas and solution between two syringes through a fine mesh. Techniques are described for minimising the amount of nitrogen in a canister or syringe based product. A technique for generating and delivering foam simultaneously using a syringe based device is also disclosed.Type: ApplicationFiled: April 23, 2010Publication date: August 12, 2010Applicant: BTG International Ltd.,Inventors: David Dakin Iorwerth WRIGHT, Anthony David Harman, Nikki Robinson, Garry Hodges, Adil Kadar, Geoffrey D. Moggridge, Hugh Van Liew
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Patent number: 7763269Abstract: A therapeutic foam for the treatment of, inter alia, varicose veins comprises a sclerosing solution foamed with a physiological gas such as carbon dioxide, oxygen or a mixture thereof. The foam has a nitrogen content of less than 0.8%. It may be generated using a pressurised canister system incorporating a fine mesh of micron dimensions through which the gas and sclerosing liquid are passed to make the foam. Alternatively, the foam may be generated by passing gas and solution between two syringes through a fine mesh. Techniques are described for minimising the amount of nitrogen in a canister or syringe based product. A technique for generating and delivering foam simultaneously using a syringe based device is also disclosed.Type: GrantFiled: November 17, 2004Date of Patent: July 27, 2010Assignee: BTG International Ltd.Inventors: David Dakin Iorwerth Wright, Anthony David Harman, Nikki Robinson, Garry Hodges, Adil Kadar, Geoffrey D. Moggridge, Hugh Van Liew
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Patent number: 7731986Abstract: A therapeutic foam for the treatment of, inter alia, varicose veins comprises a sclerosing solution foamed with a physiological gas such as carbon dioxide, oxygen or a mixture thereof. The foam has a nitrogen content of less than 0.8%. It may be generated using a pressurised canister system incorporating a fine mesh of micron dimensions through which the gas and sclerosing liquid are passed to make the foam. Alternatively, the foam may be generated by passing gas and solution between two syringes through a fine mesh. Techniques are described for minimising the amount of nitrogen in a canister or syringe based product. A technique for generating and delivering foam simultaneously using a syringe based device is also disclosed.Type: GrantFiled: November 17, 2004Date of Patent: June 8, 2010Assignee: BTG International Ltd.Inventors: David Dakin Iorwerth Wright, Anthony David Harman, Nikki Robinson, Garry Hodges, Adil Kadar, Geoffrey D. Moggridge, Hugh Van Liew
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Publication number: 20090286794Abstract: The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general formula (I) below or a pharmacologically permitted salt thereof; and also to nitrogen-containing heteroaryl derivatives having specific substituents, or pharmacologically permitted salts thereof, which are valuable as preventives or remedies for Alzheimer's disease, or as amyloid protein fibril-formation inhibitors: (where, R1 and R2 are H or alkyl; Z1 and Z2 are H, alkyl, alkoxy, haloalkyl or halogeno; Z3 is alkoxy, SH, alkylthio, NH2, mono- or di-alkylamino, OH or halogeno; Z4 and Z5 are H or halogeno; and A is 4,6-pyrimidine-1,3-diyl, 1,3,5-triazine-2,6-diyl, etc).Type: ApplicationFiled: July 27, 2009Publication date: November 19, 2009Applicant: BTG International Ltd.Inventors: Masaki Meguro, Tomiichiro Oda, Yasuhiro Nakagami, Shinji Marumoto, Kazuo Koyama, Isao Kaneko
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Publication number: 20090286809Abstract: The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general formula (I) below or a pharmacologically permitted salt thereof; and also to nitrogen-containing heteroaryl derivatives having specific substituents, or pharmacologically permitted salts thereof, which are valuable as preventives or remedies for Alzheimer's disease, or as amyloid protein fibril-formation inhibitors: (where, R1 and R2 are H or alkyl; Z1 and Z2 are H, alkyl, alkoxy, haloalkyl or halogeno; Z3 is alkoxy, SH, alkylthio, NH2, mono- or di-alkylamino, OH or halogeno; Z4 and Z5 are H or halogeno; and A is 4,6-pyrimidine-1,3-diyl, 1,3,5-triazine-2,6-diyl, etc).Type: ApplicationFiled: July 27, 2009Publication date: November 19, 2009Applicant: BTG International Ltd.Inventors: Masaki Meguro, Tomiichiro Oda, Yasuhiro Nakagami, Shinji Marumoto, Kazuo Koyama, Isao Kaneko
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Patent number: 7604185Abstract: Improved therapeutic sclerosing microfoams and methods and devices for making them are provided that have advantage in producing a consistent profile injectable foam with minimal input by the physician yet using high volume percentages of blood dispersible gases, thus avoiding use of potentially hazardous amounts of nitrogen.Type: GrantFiled: September 14, 2005Date of Patent: October 20, 2009Assignee: BTG International Ltd.Inventors: Tariq Osman, Sheila Bronwen Flynn, David Dakin Iorwerth Wright, Anthony David Harman, Timothy David Boorman
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Patent number: RE40640Abstract: Injectable microfoam for scleroteraphy. The sclerotherapy of varices is based on the injection of liquid substances capable of suppressing them. The present invention relates to the preparation of sclerosing substances in the form of a microfoam. The microfoam is prepared with sclerosing agents, and is then injected in the vein to be treated, so that the microfoam displaces the blood contained in the vein and provides for the contact of the sclerosing agent with the vascular endothelium, with a predetermined known concentration and during a controllable time.Type: GrantFiled: September 15, 2004Date of Patent: February 17, 2009Assignee: BTG International Ltd.Inventors: Juan Cabrera Garrido, Juan Cabrera Garcia-Olmedo