Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
Type:
Grant
Filed:
March 10, 2017
Date of Patent:
February 26, 2019
Assignees:
UNITY BIOTECHNOLOGY, INC., BUCK INSTITUE FOR RESEARCH ON AGING, MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Inventors:
Remi-Martin Laberge, Judith Campisi, Albert Davalos, Marco Demaria, Nathaniel David, Yi Zhu, James L. Kirkland, Tamar Tchkonia