Abstract: An apparatus for delivering at least one therapeutic agent to a dental tissue of a subject includes at least one electrode, a medicament layer including at least one therapeutic agent, an electrical signal source, and logic configured to control the electrical signal source. At least one electrode has oppositely disposed, dental mouthpiece-shaped first and second major surfaces. The first major surface is curved such that the first major surface substantially conforms to the contour of the dental tissue when placed in contact with the dental tissue. The medicament layer is disposed on at least a portion of the second major surface. The electrical signal source provides a signal having certain characteristics and is electrically connected to at least one electrode. The certain characteristics comprise at least one orienting frequency and at least one motivating frequency sufficient to motivate at least one therapeutic agent into the dental tissue.