Abstract: Microbicidal compositions containing synergistic combinations of propiconazole, (RS)-1-2-[(2,4-dichlorophenyl)-2-propyl-1,3-dioxalan-2ylmethyl]-1H-1,2,4-t riazole, and 2-mercaptobenzothiazole or alkali metal salt thereof are described. The propiconazole and 2-mercaptobenzothiazole or an alkali metal salt thereof are applied to a substrate or aqueous system subject to the growth of at least one microorganism. Methods for controlling the growth of microorganisms on various substrates and in various aqueous systems are also described. The combination of propiconazole and 2-mercaptobenzothiazole or an alkali metal salt thereof is particularly useful as microbicidal in the leather industry, the lumber industry, the papermaking industry, the textile industry, the agricultural industry, and the coating industry, as well as in industrial process waters.
Abstract: The present invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one polyglycol fatty acid ester to inhibit bacterial adhesion to the submergible surface. The present invention also relates to a method for controlling biofouling of an aqueous system. This method adds an effective amount of at least one polyglycol fatty acid ester to inhibit bacteria from adhering to a submerged surface within the aqueous system. This method effectively controls biofouling without substantially killing the fouling organisms. The present invention also relates to a composition containing polyglycol fatty acid esters and useable in the above methods. The compositions comprise at least one polyglycol fatty acid ester in an amount effective to inhibit bacteria from adhering to submergible or submerged surfaces.
Type:
Grant
Filed:
September 29, 1995
Date of Patent:
August 29, 2000
Assignee:
Buckman Laboratories International Inc
Inventors:
Daniel E. Glover, Marilyn S. Whittemore, Stephen D. Bryant
Abstract: Compositions comprising an ionene polymer and a salt of dodecylamine are disclosed which are synergistically effective compared to the respective components alone in controlling the growth of microorganisms in or on a material or medium. Methods to control the growth of microorganisms with the use of the compositions of the present invention are also disclosed.
Type:
Grant
Filed:
September 10, 1998
Date of Patent:
August 15, 2000
Assignee:
Buckman Laboratories International, Inc.
Inventors:
Fernando Del Corral, Percy Jaquess, David Oppong
Abstract: The invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one sulfamic acid or salt thereof to inhibit bacterial adhesion to the submergible surface. The invention also relates to a method for controlling biofouling of an aqueous system. This method adds an effective amount of at least one sulfamic acid or salt thereof to inhibit bacteria from adhering to a submerged surface within the aqueous system. This method effectively controls biofouling without substantially killing the fouling organisms. The sulfamic acid used in the method of the invention has the formula R.sup.1 R.sup.2 NS(O).sub.2 (OH). In this formula, R.sup.1 and R.sup.2 are independently a hydrogen, a C.sub.4 -C.sub.20 alkyl group or a cyclohexyl group. However, R.sup.1 and R.sup.2 are not both hydrogen. Alternatively, R.sup.1 and R.sup.
Type:
Grant
Filed:
July 29, 1997
Date of Patent:
August 15, 2000
Assignee:
Buckman Laboratories International Inc.
Inventors:
Thomas E. McNeel, Marilyn S. Whittemore, Stephen D. Bryant, Graciela H. Vunk
Abstract: The present invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one thiourea to inhibit bacterial adhesion to the submergible surface. The present invention also relates to a method for controlling biofouling of an aqueous system. This method adds an effective amount of at least one thiourea to inhibit bacteria from adhering to a submerged surface within the aqueous system. This method effectively controls biofouling without substantially killing the bactaria. The thiourea used in the method of the invention has the following formula a compound of the formula: The present invention also relates to compositions containing thiourea compounds and useable in the above methods. The compositions comprise at least one thiourea in an amount effective to inhibit bacteria from adhering to submergible or submerged surfaces.
Abstract: Microbicidal compositions are described. The compositions comprise (a) 2-(Thiocyanomethylthio)benzothiazole (TCMTB) and (b) an N-alkyl heterocyclic compound of the formula: ##STR1## The variable "n" ranges from 5 to 17, and the heterocyclic ring defined by ##STR2## is a substituted or unsubstituted ring having four to eight members. Components (a) and (b) are present in a combined amount effective to control the growth of at least one microorganism. Methods for controlling the growth of microorganisms on various substrates or in aqueous systems are also described. Also described is the industrial application of the microbicidal composition in the leather industry, the lumber industry, the papermaking industry, the textile industry, the agricultural industry, and the coating industry, as well as in aqueous systems.
Type:
Grant
Filed:
November 26, 1997
Date of Patent:
May 9, 2000
Assignee:
Buckman Laboratories International, Inc.
Inventors:
Marilyn S. Whittemore, Daniel E. Glover, S. Rao Rayudu, Dean T. Didato
Abstract: A method for increasing the effectiveness of a microbicide is described, wherein a microbicide and an N-alkyl heterocyclic compound are applied to a substrate or aqueous system subject to the growth of microorganisms. The N-alkyl heterocyclic compound is applied in an amount effective to increase the microbicidal activity of the microbicide. The N-alkyl heterocyclic compound has the formula: ##STR1## The variable "In" ranges from 5 to 17, and the heterocyclic ring defined by ##STR2## is a substituted or unsubstituted ring having four to eight members. Microbicidal compositions are described where the microbicide and the N-alkyl heterocyclic compound are present in a combined amount effective to control the growth of at least one microorganism. Methods for controlling the growth of microorganisms on various substrates and in various aqueous systems are also described.
Type:
Grant
Filed:
May 30, 1995
Date of Patent:
March 7, 2000
Assignee:
Buckman Laboratories International Inc
Inventors:
Marilyn S. Whittemore, Daniel E. Glover, S. Rao Rayudu
Abstract: The present invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one amide to inhibit bacterial adhesion to the submergible surface. The present invention also relates to a method for controlling biofouling of an aqueous system. This method adds an effective amount of at least one amide to inhibit bacteria from adhering to a submerged surface within the aqueous system. This method effectively controls biofouling without substantially killing the bacteria. The amide used in the method of the invention has the following formula: ##STR1## The present invention also relates to compositions containing amides and useable in the above methods. The compositions comprise at least one amide in an amount effective to inhibit bacteria from adhering to submergible or submerged surfaces.
Type:
Grant
Filed:
September 29, 1998
Date of Patent:
February 29, 2000
Assignee:
Buckman Laboratories International, Inc.
Inventors:
Marilyn S. Whittemore, Daniel E. Glover, Mark L. Zollinger, Stephen D. Bryant
Abstract: Compositions comprising an ionene polymer and a pyrithione salt are disclosed which are synergistically effective compared to the respective components alone in controlling the growth of microorganisms in or on a material or medium. Methods to control the growth of microorganisms and prevent spoilage caused by microorganisms with the use of the compositions of the present invention are also disclosed.
Type:
Grant
Filed:
April 30, 1998
Date of Patent:
December 28, 1999
Assignee:
Buckman Laboratories International, Inc.
Inventors:
David Oppong, Russel E. Fues, Graciella H. Canullo
Abstract: ASA sizing emulsions containing low and high molecular weight cationic polymers are described. An ASA sizing emulsion of the invention contains 25 to 99 percent by weight water, 0.003 to 60 percent by weight ASA, 0.003 to 50 percent by weight of a cationic polymer mixture, and 0 to 2 percent by weight of a surfactant. The cationic polymer mixture contains 75 to 99 percent by weight of an ionene polymer and 1 to 25 percent by weight of a high molecular weight polyethyleneimine polymer. In the sizing emulsion, the ASA has a particle size ranging from 0.5 to 3 microns. A method for sizing paper using such an emulsion is also described.
Type:
Grant
Filed:
June 25, 1997
Date of Patent:
October 5, 1999
Assignee:
Buckman Laboratories International, Inc.
Abstract: Compositions for controlling the growth of microorganisms in or on a product, material, or medium comprising synergistically effective amounts of (a) dodecylmorpholine or a salt thereof and (b) dodecylamine or a salt thereof are disclosed. Methods to control the growth of microorganisms and prevent spoilage caused by microorganisms with the use of the compositions of the present invention are also disclosed.
Type:
Grant
Filed:
September 16, 1997
Date of Patent:
July 27, 1999
Assignee:
Buckman Laboratories International, Inc.
Inventors:
David Oppong, Percy A. Jaquess, Fernando Del Corral, Marilyn S. Whittemore
Abstract: A method for increasing the effectiveness of an anti-fungal compound is described. In the method, an anti-fungal compound and an N-alkyl heterocyclic compound or a salt thereof are administered to a mammal in a combined amount effective to treat a fungal infection. The N-alkyl heterocyclic compound or salt thereof is present in an amount effective to potentiate or increase the anti-fungal activity of the anti-fungal compound. The N-alkyl heterocyclic compound has the formula: ##STR1## The variable "n" ranges from 5 to 17, and the heterocyclic ring defined by ##STR2## is a substituted or unsubstituted ring having four to eight members. A pharmaceutical composition is described where the anti-fungal compound and the N-alkyl heterocyclic compound or salt thereof are present in a combined amount effective to treat a fungal infection.
Type:
Grant
Filed:
August 8, 1997
Date of Patent:
July 20, 1999
Assignee:
Buckman Laboratories International, Inc.
Abstract: The present invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one N-alkyl heterocyclic compound to inhibit bacterial adhesion to the submergible surface. The present invention also relates to a method for controlling biofouling of an aqueous system. This method adds an effective amount of at least one N-alkyl heterocyclic compound to inhibit bacteria from adhering to a submerged surface within the aqueous system. This method effectively controls biofouling without substantially killing the fouling organisms. The N-alkyl heterocyclic compound used in the method of the invention has the following formula: ##STR1## The substituent R.sup.1 is a C.sub.8 -C.sub.20 alkyl group. The heterocyclic ring is a 5-8 membered heterocyclic ring where X is O, NH, or CH.sub.2. R.sup.2 is methyl, hydroxymethyl, or hydroxyethyl. The integer n ranges from 0 to 3.
Type:
Grant
Filed:
September 29, 1995
Date of Patent:
May 11, 1999
Assignee:
Buckman Laboratories International Inc.
Inventors:
Marilyn S. Whittemore, Daniel E. Glover, Joe C. Steelhammer, Stephen D. Bryant
Abstract: Microbicidal compositions are described. The compositions contain (a) propiconazole and (b) dodecylamine or a dodecylamine salt. The propiconazole and dodecylamine or dodecylamine salt are present in a synergistically effective amount to control the growth of at least one microorganism. Methods for controlling the growth of microorganisms on various substrates or in aqueous systems are also described. Also described is the industrial application of the microbicidal composition in the leather industry, the lumber industry, the papermaking industry, the textile industry, the agricultural industry, and the coating industry, as well as in aqueous systems.
Type:
Grant
Filed:
March 21, 1997
Date of Patent:
May 11, 1999
Assignee:
Buckman Laboratories International Inc.
Inventors:
Percy A. Jacquess, David Oppong, Sheldon M. Ellis, L. Fernando Del Corral
Abstract: The invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one amino methyl phosphonic acid or salt thereof to inhibit bacterial adhesion to the submergible surface. The invention also relates to a method for controlling biofouling of an aqueous system. This method adds an effective amount of at least one amino methyl phosphonic acid or salt thereof to inhibit bacteria from adhering to a submerged surface within the aqueous system. This method effectively controls biofouling without substantially killing the fouling organisms. The amino methyl phosphonic acid used in the methods of the invention has the formula R.sup.1 R.sup.2 NCH.sub.2 P(O)(OH).sub.2. In this formula, R.sup.1 and R.sup.2 are independently a C.sub.6 -C.sub.20 alkyl group or a CH.sub.2 P(O)(OH).sub.2 group. However, R.sup.1 and R.sup.2 are not both a CH.sub.2 P(O)(OH).sub.2 group. Alternatively, R.sup.1 and R.sup.
Type:
Grant
Filed:
July 29, 1997
Date of Patent:
March 30, 1999
Assignee:
Buckman Laboratories International Inc.
Inventors:
Thomas E. McNeel, Marilyn S. Whittemore, Stephen D. Bryant, Graciela H. Vunk
Abstract: The present invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one fluorosurfactant to inhibit bacterial adhesion to the submergible surface. The present invention also relates to a method for controlling biofouling of an aqueous system. This method adds an effective amount of at least one fluorosurfactant to inhibit bacteria from adhering to a submerged surface within the aqueous system. This method effectively controls biofouling without substantially killing the bacteria fouling organisms. The fluorosurfactant used in the method of the invention is an anionic or nonionic fluorosurfactant selected from: R.sub.f CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2 CO.sub.2 Li, (R.sub.f CH.sub.2 CH.sub.2 O)P(O) (ONH.sub.4).sub.2, (R.sub.f CH.sub.2 CH.sub.2 O).sub.2 P(O) (ONH.sub.4), (R.sub.f CH.sub.2 CH.sub.2 O)P(O) (OH).sub.2, (R.sub.f CH.sub.2 CH.sub.2 O).sub.2 P(O) (OH), R.sub.f CH.sub.2 CH.sub.2 O (CH.
Type:
Grant
Filed:
December 27, 1995
Date of Patent:
March 9, 1999
Assignee:
Buckman Laboratories International Inc.
Inventors:
Daniel E. Glover, Joe C. Steelhammer, Stephen D. Bryant
Abstract: Compositions comprising a mixture of 2-(thiocyanomethylthio)benzothiazole and methylene-bis(thiocyanate) with dimethylamide of a carboxylic acid are disclosed which are synergistically effective compared to the respective components alone in controlling the growth of microorganisms in or on a product, material, or medium. Methods to control the growth of microorganisms and prevent spoilage caused by microorganisms with the use of the compositions of the present invention are also disclosed.
Type:
Grant
Filed:
July 11, 1997
Date of Patent:
February 23, 1999
Assignee:
Buckman Laboratories International, inc.
Abstract: A diamine useful as a catalyst for the polymerization of urethane. A method of making the catalyst comprises reacting a spiro quaternary amine with a secondary amine. The spiro quaternary amine is also useful as an antimicrobial agent.
Type:
Grant
Filed:
November 5, 1993
Date of Patent:
February 9, 1999
Assignee:
Buckman Laboratories International, Inc.
Abstract: The present invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an ionene polymer and a salt of dodecylamine in a combined amount effective to inhibit bacterial adhesion to the submergible surface. The present invention also relates to a method for controlling biofouling of an aqueous system. This method adds an ionene polymer and a salt of dodecylamine in a combined amount effective to inhibit bacteria from adhering to a submerged surface within the aqueous system. This method effectively controls biofouling without substantially killing the fouling organisms. The present invention also relates to compositions containing an ionene polymer and a salt of dodecylamine and useable in the above methods. The compositions comprise an ionene polymer and a salt of dodecylamine in a combined amount effective to inhibit bacteria from adhering to submergible or submerged surfaces.
Type:
Grant
Filed:
July 1, 1997
Date of Patent:
February 2, 1999
Assignee:
Buckman Laboratories International, Inc.
Inventors:
Percy A. Jaquess, Luis Fernando Del Corral, Richard A. Clark
Abstract: Compositions comprising a compound of formula I ##STR1## where R and R' are independently selected from hydrogen and alkyl of 1 to 4 carbon atoms, R" is a moiety selected from the group consisting of (a) hydrogen, (b) a halogen atom selected from the group consisting of F, Cl, Br, and I, and (c) a nitro group, or the hydrochloride salt of said compound; and at least one preservative are disclosed which are synergistically effective compared to the respective components alone in controlling and/or reducing the growth of microorganisms in or on a material or medium. Methods to control and/or reduce the growth of microorganisms and prevent spoilage caused by microorganisms with the use of the compositions of the present invention are also disclosed.
Type:
Grant
Filed:
May 27, 1997
Date of Patent:
January 12, 1999
Assignee:
Buckman Laboratories International, Inc.