Abstract: Device for locking and unlocking at least one interface card plugged into a socket of a receiving system (2) linked to a data processing system. The device (1) comprises a box (3) mounted to the receiving system (2) and receiving at least one sliding locking/unlocking element (4a-4n) for locking/unlocking interface cards. Each of elements (4a-4n) is disposed opposite a socket in a position that blocks the access to or removal of an interface card. Each element (4a-4n) comprising an element for controlling the power supply (63) of the card, a visual element for indicating the operation and the recognition of the card, and a detecting element for detecting the intent to unlock the card. The device (1) includes a communication element that makes it possible to transmit signals between the data processing system and the device.