Abstract: Provided herein are methods of treating cancer comprising administering antibodies and antigen-binding fragments thereof that bind the extracellular domain of the HER3 receptor and inhibit various HER3 receptor related functions via ligand-dependent and/or ligand-independent mechanisms, and dosing regimens for related monotherapies and combination therapies.
Type:
Application
Filed:
September 10, 2015
Publication date:
July 6, 2017
Applicant:
BULLDOG PHARMACEUTICALS, INC.
Inventors:
Theresa Marie LAVALLEE, Carolyn Fowler SIDOR, Diego ALVARADO