Abstract: A method for identifying a chemical that acts as an agonist for a G-protein coupled cell surface (GPC) receptor.

Abstract: A method for detecting the interaction between an oligomeric molecule and a target is provided. A plurality of beads is applied to a substrate, each bead having associated therewith multiple copies of only a single oligomeric molecule. The beads are substantially spaced-apart from one another and are substantially immobilized on the substrate. Conditions are applied such that a substantial portion of the multiple copies associated with each bead can disassociate from and diffuse into the substrate, the substrate constructed and arranged to permit only substantially localized diffusion. A localized signal occurring as a result of the diffusion is detected. Coated beads and libraries of coated beads also are provided.

Abstract: A method for identifying a chemical that acts as an agonist for a G-protein coupled cell surface (GPC) receptor.