Patents Assigned to Burnstein Technologies, Inc.
  • Methods and apparatus for blood typing with optical bio-disc
    Patent number: 7087203
    Abstract: This invention relates to clinical diagnostic assays and related optical bio-discs and a disc-reading apparatus. The invention is directed to a method for determining the blood cell type of an individual.
    Type: Grant
    Filed: November 19, 2001
    Date of Patent: August 8, 2006
    Assignees: Nagaoka & Co., Ltd., Burnstein Technologies, Inc.
    Inventors: John Francis Gordon, Susan Newcomb Hurt, David Samuel Cohen
  • Surface assembly for immobilizing DNA capture probes in genetic assays using enzymatic reactions to generate signal in optical bio-discs and methods relating thereto
    Patent number: 7083920
    Abstract: The present invention relates to methods and systems for the detection of specific sequences of nucleic acids or oligonucleotides. It relates more particularly to a conjugated enzyme based assay system utilizing reflective and/or transmissive optical bio-discs for detection of specific sequences of nucleic acids. In the assay according to the present invention, an enzyme reaction is used to detect the presence of an analyte (DNA or RNA) in a microchannel in an optical bio-disc. The analyte is immobilized by hybridization with a specific capture probe on a capture layer on the surface and the signal that is generated is localized and specific. The signal can be in the form of a pellet, a fluorescent product, and/or a colored product, and can be detected and quantified by an optical bio-disc reader utilized in conjunction with the inventions hereof. This assay is thus quantitative in nature.
    Type: Grant
    Filed: May 17, 2002
    Date of Patent: August 1, 2006
    Assignees: Nagaoka & Co. Ltd., Burnstein Technologies, Inc.
    Inventors: Martina Elisabeth Werner, Ramon Magpantay Valencia, John Francis Gordon
  • Supramolecules containing binding and therapeutic molecules bound to hybridized nucleic acids
    Patent number: 6814964
    Abstract: A supramolecule has a first supramolecular component including a first effector molecule covalently joined to a first nucleic acid, and a second supramolecular component including a second effector molecule covalently joined to a second nucleic acid, wherein the second nucleic acid has a region of at least partial complementarity to the first nucleic acid, wherein the first nucleic acid is in a base pairing relationship with the second nucleic acid and the first or second effector molecules are proteins, polypeptides, lipids or sugars. The supramolecule may further have a third supramolecule component which includes a third effector molecule covalently joined to a third nucleic acid, wherein the third nucleic acid has a region of at least partial complementary to the first nucleic acid or the second nucleic acid and wherein the third nucleic acid is in a base pairing relationship with the second nucleic acid or the first nucleic acid.
    Type: Grant
    Filed: March 25, 2002
    Date of Patent: November 9, 2004
    Assignees: Nagaoka & Co. Ltd., Burnstein Technologies, Inc.
    Inventors: Jorma Virtanen, Sinikka Virtanen