Abstract: This invention relates to a device for the constant replenishment of an animal dipping bath, or for use in any situation where it is desired to have a concentrate diluted with a liquid with little or no liquid supply pressure.The device consists of a two-component rocking-pan arrangement 8 and 9 for receiving and discharging the mixture and a metering arrangement for discharging concentrate in the pan. The metering arrangement consists of a double acting single piston and cylinder pump, linked to the pan, and comprises a single piston 22, and a single cylinder partitioned by the piston into 2 chambers, 25 and 26 each chamber being capable of receiving and discharging quantities of concentrate. The arrangement of the pump is such that when one chamber is discharging concentrate into the pan the other is receiving concentrate from the supply line, and concentrate is delivered to that one of the two components which is about to be filled with diluent. The device is particularly useful for sheep-dipping purposes.

Abstract: Known perfume dispensing materials such as those which comprise paper or ceramics have been found to affect adversely the odor of the perfume they dispense. Vermiculite appears to overcome this disadvantage when used in a perfume dispensing material.

Abstract: The novel compound 6-deoxyacyclovir is enzymatically converted to acyclovir by xanthine oxidase/dehydrogenase or aldehyde oxidase in vivo, i.e. within the body of the animal being treated. The enzymatic conversion may also be effected ex vivo (i.e. in vitro) as a method of synthesizing acyclovir.

Abstract: Novel peptides of formula (I) ##STR1## wherein R.sup.1 is hydrogen, alkyl of 1 or 2 carbon atoms or an amidino group,R.sup.2 is alkyl of 1 or 2 carbon atoms,R.sup.3 is hydrogen or carbamyl,X.sup.2 is a D-radical having the structure: ##STR2## Z.sup.1 and Z.sup.2 are the same or different and each is hydrogen, halo, nitro or trifluoromethyl and at least one is other than hydrogen,m is 2, 3 or 4 andn is 0, 1 or 2,provided that when R.sup.3 is carbamyl then n is always 1;and salts thereof.The compounds have a selectively peripheral analgesic effect when administered to mammals and also exhibit antidiarrhoeal and antitussive activity and may thus be used in human or veterinary medicine for the relief or prevention of pain, for the treatment of diarrhoea or dysentery and for the suppression of cough.

Abstract: Prostacyclin, its salts, biosynthesis and synthesis thereof, pharmaceutical formulations containing them, and their use in medicine.

Abstract: This invention is directed to novel ether compounds of formula (I) ##STR1## which are of value in medicine in the palliation of haemoglobinopathies, in particular sickle-cell anemia, and also in the palliation of pulmonary dyefunction, protection from the effects of hypoxia and the radio-sensitization of tumours. The invention is also directed to methods for the preparation of the ether compounds, to pharmaceutical formulations containing them, the preparation of such formulations and the use of the compounds in human medicine. Also provided by the invention are intermediates of value in the preparation of the ether compounds, by the methods described, and the preparation of the intermediates.

Abstract: The present invention relates to compounds of formula (I) ##STR1## wherein Ar is a fluoranthene or substituted fluoranthene ring system; R.sup.1 is a C.sub.1-3 alkylene moiety; R.sup.2 is hydrogen or a C.sub.1-6 alkyl group; R.sup.3 is a hydroxy C.sub.1-6 alkyl group; R.sup.4 and R.sup.5 are the same or different and are hydrogen, C.sub.1-6 alkyl or hydroxy C.sub.1-6 alkyl, esters thereof derived from condensation of carboxylic acids and hydroxyl groups of R.sup.3, R.sup.4, and R.sup.5 ;Acid addition salts thereof, which have been found useful for the treatment of tumors in mammals.

Abstract: The present invention relates to compounds of formula (I) ##STR1## wherein Ar is a perylene or substituted perylene ring system;R.sup.1 is a C.sub.1-3 alkylene moiety;R.sup.2 is hydrogen or a C.sub.1-6 alkyl group;R.sup.3 is hydroxyl C.sub.1-6 alkyl group;R.sup.4 and R.sup.5 are the same or different and are hydrogen, C.sub.1-6 alkyl or hydroxy C.sub.1-6 alkyl, esters thereof derived from condensation of carboxylic acids and hydroxyl groups of R.sup.3, R.sup.4, and R.sup.5 ;Acid addition salts thereof, which have been found useful for the treatment of tumors in mammals.

Abstract: This application is directed to treatment of psoriasis with a pyrido pyrimidine compound such as 2,4-diamino-6-(3,4-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine.

Abstract: The present invention relates to compounds of formula (I) ##STR1## wherein Ar is a phenanthrene or substituted phenanthrene ring system;R.sup.1 is a C.sub.1-3 alkylene moiety;R.sup.2 is hydrogen or a C.sub.1-6 alkyl group;R.sup.3 is a hydroxy C.sub.1-6 alkyl group;R.sup.4 and R.sup.5 are the same or different and are hydrogen, C.sub.1-6 alkyl or hydroxy C.sub.1-6 alkyl, esters thereof derived from condensation of carboxylic acids and hydroxyl groups of R.sup.3, R.sup.4, and R.sup.5 ;Acid addition salts thereof, which have been found useful for the treatment of tumors in mammals.

Abstract: A method of treatment of pychosexual dysfunction in male and female human beings by the administration of the compound of the formula (I) ##STR1## or a pharmaceutically acceptable acid addition salt thereof in a non-toxic, effective therapeutic amount (calculated as base) to a human being in need thereof.

Abstract: Compounds of the general formula ##STR1## wherein Ph is a phenyl group which is optionally substituted by one or more substituents selected from halo (i.e. fluoro, chloro, bromo or iodo), C.sub.1-4 alkyl, amino, C.sub.1-4 alkylamino, di-C.sub.1-4 alkylamino, nitro, sulphonyl, aminosulphonyl, trihalomethyl, carboxy, C.sub.1-4 alkoxycarbonyl, amido, C.sub.1-4 alkylamido, C.sub.1-4 alkoxy, C.sub.2-4 alkenyl, cyano, aminomethyl, or methylsulphonyl; Y is a group of formula ##STR2## where R.sup.1 is hydrogen or methyl; R.sup.2 is alkyl of 1 to 3 carbon atoms or is methylthiomethyl; and Z is --OR.sup.3 or --NR.sup.4 R.sup.5 where R.sup.3, R.sup.4 and R.sup.5 are each hydrogen or alkyl of 1 to 4 carbon atoms and R.sup.3 can further be phenylalkyl having 1 to 3 carbon atoms in the alkylene moiety thereof, or phenyl; and basic salts thereof. These compounds have an advantageous enkephalinase inhibitory activity which renders the compounds useful in medical therapy, e.g.

Abstract: In the synthesis of calcium leucovorin (calcium 5-formyl-5,6,7,8-tetrahydrofolate), the use of an amine base in the conversion of anhydroleucovorin (5,10-methenyl-5,6,7,8-tetrahydrofolic acid) to leucovorin unexpectedly results in a pure (USP) product directly from the reaction mixture.

Abstract: Known perfume dispensing materials such as those which comprise paper or ceramics have been found to affect adversely the odor of the perfume they dispense. Vermiculite appears to overcome this disadvantage when used in a perfume dispensing material.

Abstract: This invention provides the neuromuscular blocking agents of formula (I): ##STR1## where B and C are each a group of formula (II) and are meta or para to one another: ##STR2## wherein D is CH.sub.2 CH.sub.2 or CH.dbd.CH (preferably trans); Y is alkyl of 1-4 carbon atoms (methyl, ethyl, propyl or butyl); E and F and H or OCH.sub.3 ; X.sup.- is an anion, preferably pharmaceutically acceptable; and the substituted benzyl and substituted propyl groups are in a trans relationship relative to each other in the nitrogen-containing ring.Methods for preparing the compounds, pharmaceutical formulations containing the compounds, and their use are also described.

Abstract: A method of treatment of thrombo-embolic conditions in a mammal including man comprising the administration of a non-toxic effective amount of the compound of Formula (I) is described: ##STR1## Preferred formulations include those suitable for oral, rectal or parenteral administration, and the preferred dose is in the range of from 1 to 120 mg per kg body weight of the compound per day.

Abstract: Hydantoins of formula (I) ##STR1## have biological properties related to those of naturally occurring prostaglandins and may be used in medicine, for example in the treatment of thrombosis.

Abstract: The novel compounds 3-deaza-2'-deoxyadenosine and certain of its derivatives and their pharmaceutically acceptable salts have anti-inflammatory activity as well as immune response suppression activity. 3-Deaza-2'-deoxyadenosine and certain of its intermediates are synthesized by the enzyme catalyzed reaction of the appropriately substituted 3-deazapurine with a 2'-deoxyribose donor.

Abstract: Compounds of formula (I) ##STR1## inhibit both the cyclo-oxygenase and lipoxygenase pathways of arachidonic acid oxygenation and are useful in medicine as, e.g., anti-inflammatory and anti-asthmatic agents.The compounds may be administered as the raw chemical or in association with a carrier as a pharmaceutical formulation.The compounds may be prepared by methods analogous to those known in the art, e.g. by the method of Duffin and Kendall in J. Chem. Soc. (1954), 408-415, or by other methods.

Abstract: A dissolution system for pharmaceutical solid oral dosage forms (medicinal tablets) comprising one or more open-top flasks for receiving a solvent media and the solid dosage forms to be tested, together with structure for delivering a solvent media into the flasks, structure for agitating the solvent media, structure for removing test samples, and structure in the form of a drain valve assembly at the bottom of each flask for removing residual solute and flushing the tank.