Patents Assigned to BVW HOLDING AG
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Patent number: 11141260Abstract: Bio-adhesive textured surfaces are described which allow implants to be localized within a living body. Hierarchical levels of texture on an implantable medical device, some capable of establishing a Wenzel state and others a Cassie state, are employed to interface with living structures to provide resistance to device migration. Since a gaseous state is traditionally required to establish a Cassie or Wenzel state, and gases do not remain long in living tissue, described are tissue/device interactions analogous to the above states with the component normally represented by a gas replaced by a bodily constituent, wherein separation of tissue constituents develops and an analogous Cassie, Wenzel or Cassie-Wenzel state evolves.Type: GrantFiled: March 28, 2019Date of Patent: October 12, 2021Assignee: BVW Holding AGInventors: Lukas Bluecher, Michael Milbocker
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Patent number: 11123364Abstract: A medical composition and devices made from the composition for the delivery of extracts obtained from Boswellia genus, similar compounds synthetically derived, and in particular derivatives of triterpenes is disclosed. The medical device may be implantable, or alternatively a device which contacts the interior of a mammalian body. The medical device may be comprised, of or present an absorbable component containing Boswellia derivatives, or an eluting component. When administered into a particular body site, the Boswellia component may be released substantially and immediately, released slowly, or not released, into the body and residing actively on the medical device surface.Type: GrantFiled: June 21, 2012Date of Patent: September 21, 2021Assignee: BVW Holding AGInventors: Michael T. Milbocker, Lukas von Bluecher
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Patent number: 11103340Abstract: Bio-selective textured surfaces are described which mediate foreign body response, bacterial adhesion, and tissue adhesion on devices implanted in a mammalian body. Hierarchical levels of texture, some capable of establishing a Wenzel state others a Cassie state, are employed to interface with living structures, either to promote or discourage a particular biological response/interaction. Since a gaseous state is traditionally required to establish a Cassie or Wenzel state, and gases do not remain long in living tissue, described are tissue/device interactions analogous to the above states with the component normally represented by a gas replaced by a bodily constituent, wherein separation of tissue constituents develops and a desired interaction state evolves.Type: GrantFiled: December 18, 2017Date of Patent: August 31, 2021Assignee: BVW HOLDING AGInventors: Lukas Bluecher, Michael Milbocker
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Patent number: 11051567Abstract: The present disclosure provides microstructured hydrophobic surfaces and devices for gripping wet deformable surfaces. The surfaces and devices disclosed herein utilize a split contact Wenzel-Cassie mechanism to develop multi-level Wenzel-Cassie structures. The Wenzel-Cassie structures are separated with a spatial period corresponding to at least one wrinkle eigenmode of a wet deformable surface to which the microstructure or device is designed to contact, allowing grip of the deformable surface without slippage. Microstructures of the present invention are specifically designed to prevent the formation of Shallamach waves when a shear force is applied to a deformable surface. The multi-level Wenzel-Cassie states of the present disclosure develop temporally, and accordingly are characterized by hierarchical fluid pinning, both in the instance of slippage, and more importantly in the instance of localization.Type: GrantFiled: September 28, 2018Date of Patent: July 6, 2021Assignee: BVW Holding AGInventors: Michael Milbocker, Lukas Bluecher
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Patent number: 11013827Abstract: The invention relates to the field of tissue engineering and regenerative medicine, and particularly to a three-dimensional biomimetic tissue scaffold that exploits the use of three-dimensional print technology. Surface energy is controlled by precisely placing polymers with differing surface chemistry, and using surface texture and bulk composition to pattern absorbable and non-absorbable polymers for the purpose of promoting functional healing in a mammalian body.Type: GrantFiled: November 10, 2017Date of Patent: May 25, 2021Assignee: BVW Holding AGInventors: Lukas Bluecher, Michael Milbocker
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Patent number: 10953138Abstract: Polymer devices are disclosed with microstructured surfaces that modify their absorption pathway. Polymers which generally degrade in water by fracturing into high surface energy fragments, are modified to degrade in vivo without the formation of sharp fragments. Devices are disclosed that possess improved handling characteristics and degrade in an aqueous environment in a uniform and continuous way that favors the formation of soluble monomers rather than solid particulate. Absorbable medical implants with the disclosed surface modifications are more biocompatible, with reduced foreign body response, and dissolution into metabolizable molecular species.Type: GrantFiled: October 18, 2018Date of Patent: March 23, 2021Assignee: BVW HOLDING AGInventors: Lukas Bluecher, Kenneth Kleinhenz, Michael Milbocker
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Patent number: 10758380Abstract: The present disclosure provides stents, particularly self-expanding stents, useful for the GI tract, and more particularly, useful for treating esophageal strictures. The stents provided herein include a medial region and proximal and distal cuffs having external diameters greater than the medial region diameter when the stent is in the deployed state. The medial region comprises an open weave wire construction. An elastomeric coating circumscribes the medial region, while the may be an extension of the wire construction or separate elements. Preferably, the cuffs have a textured surface for contact with the esophageal wall tissue to resist stent migration. The elastomer coated medial region provides a barrier to tissue ingrowth, and has an enhanced radial restoring force to maintain an open passageway in a body lumen. Optionally, the stent includes an exterior sheath with a surface pattern, to which the stent couples.Type: GrantFiled: December 30, 2017Date of Patent: September 1, 2020Assignee: BVW Holding AGInventors: Lukas Bluecher, Michael Milbocker, Roel Trip
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Patent number: 10675297Abstract: The present disclosure relates to compositions A composition comprising a polymerization product of an anionic polysaccharide, a diisocyanate, and a linker, wherein the linker comprises i) an ether group, an ester group, or a combination thereof and, ii) a chain extender comprising a hydroxyl group, a thiol group, an amine group, or a combination thereof. The disclosure further relates to medical devices comprising the aforementioned compositions, and to methods of using the compositions and devices. More particularly, the compositions, devices and methods described herein are useful for preventing protein adhesions in vivo, particularly the Vroman effect.Type: GrantFiled: October 17, 2019Date of Patent: June 9, 2020Assignee: BVW Holding AGInventors: Lukas Bluecher, Michael Milbocker
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Patent number: 10668190Abstract: Disclosed are hydrogels polymerized with or around a solid biofunctional moiety, biodegradable or permanent, designed to be implantable in a mammalian body, intended to block or mitigate the formation of tissue adhesions, and intended to aid in functional healing. The hydrogels of the present invention are characterized by comprising multiphasic structural elements: a) at least one gel phase, b) at least one solid phase, c) optional polymeric chains connecting gel and solid phases, d) optional shape designs that provide for an interpenetrating geometry between gels and solids, e) optional shape designs that enhance a tissue-hydrogel interface, and f) optional shape designs that provide a biofunctional aspect. The hydrophobicity of the various phases is chosen to reduce tissue adhesion and enhance tissue healing. The morphology of the polymers comprising the gel phase is typically of high molecular weight and has morphology that encourages entanglement.Type: GrantFiled: May 3, 2017Date of Patent: June 2, 2020Assignee: BVW Holding AGInventors: Michael Milbocker, Lukas Bluecher
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Publication number: 20200113933Abstract: The present disclosure relates to compositions A composition comprising a polymerization product of an anionic polysaccharide, a diisocyanate, and a linker, wherein the linker comprises i) an ether group, an ester group, or a combination thereof and, ii) a chain extender comprising a hydroxyl group, a thiol group, an amine group, or a combination thereof. The disclosure further relates to medical devices comprising the aforementioned compositions, and to methods of using the compositions and devices. More particularly, the compositions, devices and methods described herein are useful for preventing protein adhesions in vivo, particularly the Vroman effect.Type: ApplicationFiled: October 17, 2019Publication date: April 16, 2020Applicant: BVW Holding AGInventors: Lukas Bluecher, Michael Milbocker
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Patent number: 10507015Abstract: Retraction of one or more three-dimensional or planar amorphous objects is provided to gain access for a procedure where the retracted elements are easily damaged by application of normal forces. For example, a surgical instrument to provide access to an organ or tissue plane. Microtextured surfaces are provided that provide immobilization of amorphous objects, the immobilization of which is characterized by low normal forces and high shear or in plane forces. The retraction device is comprised of microstructured surfaces on one or more arms. Preferably these arms are soft and flexible to minimize damage to retracted objects. In some instances, these arms resemble and are used as a nonslip tape. Alternatively, parts or whole arms of the retraction device are rigid to provide a supportive aspect. These arms may be configured around a handle.Type: GrantFiled: October 5, 2016Date of Patent: December 17, 2019Assignee: BVW Holding AGInventors: Michael Milbocker, Lukas Bluecher
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Patent number: 10485822Abstract: The present disclosure relates to compositions A composition comprising a polymerization product of an anionic polysaccharide, a diisocyanate, and a linker, wherein the linker comprises i) an ether group, an ester group, or a combination thereof and, ii) a chain extender comprising a hydroxyl group, a thiol group, an amine group, or a combination thereof. The disclosure further relates to medical devices comprising the aforementioned compositions, and to methods of using the compositions and devices. More particularly, the compositions, devices and methods described herein are useful for preventing protein adhesions in vivo, particularly the Vroman effect.Type: GrantFiled: October 5, 2012Date of Patent: November 26, 2019Assignee: BVW Holding AGInventors: Lukas Bluecher, Michael Milbocker
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Patent number: 10433924Abstract: A glove with an enhanced gripping textured surface is disclosed herein. In preferred embodiments, the glove contains a palm region adapted to cover the palm of a person's hand, a thumb region extending outwardly from the palm region, an index finger region disposed adjacent the thumb region, a middle finger region adjacent the index finger region, a ring finger region adjacent the middle finger region, and a little finger region adjacent the ring finger region with each region containing a textured surface. In preferred embodiments, the textured surface is formed by a plurality of dimensionally hierarchical structures superimposed in layers. The textured surface of the invention, when in contact with wet tissue, repels water at a first texture layer and traps tissue at a second texture layer, such that when in tissue contact, especially exudative tissue, tissue fixatively localizes to the glove surface.Type: GrantFiled: June 8, 2017Date of Patent: October 8, 2019Assignee: BVW Holding AGInventors: Lukas Bluecher, Michael Milbocker
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Patent number: 10292806Abstract: Bio-adhesive textured surfaces are described which allow implants to be localized within a living body. Hierarchical levels of texture on an implantable medical device, some capable of establishing a Wenzel state and others a Cassie state, are employed to interface with living structures to provide resistance to device migration. Since a gaseous state is traditionally required to establish a Cassie or Wenzel state, and gases do not remain long in living tissue, described are tissue/device interactions analogous to the above states with the component normally represented by a gas replaced by a bodily constituent, wherein separation of tissue constituents develops and an analogous Cassie, Wenzel or Cassie-Wenzel state evolves.Type: GrantFiled: January 18, 2013Date of Patent: May 21, 2019Assignee: BVW Holding AGInventors: Lukas Bluecher, Michael Milbocker
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Patent number: 10130459Abstract: Bio-selective textured surfaces are described which mediate foreign body response, bacterial adhesion, and tissue adhesion on devices implanted in a mammalian body. Hierarchical levels of texture, some capable of establishing a Wenzel state others a Cassie state, are employed to interface with living structures, either to promote or discourage a particular biological response/interaction. Since a gaseous state is traditionally required to establish a Cassie or Wenzel state, and gases do not remain long in living tissue, described are tissue/device interactions analogous to the above states with the component normally represented by a gas replaced by a bodily constituent, wherein separation of tissue constituents develops and a desired interaction state evolves.Type: GrantFiled: January 18, 2013Date of Patent: November 20, 2018Assignee: BVW Holding AGInventors: Lukas Bluecher, Michael Milbocker
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Patent number: 10034956Abstract: Disclosed are hydrogels polymerized with a biofunctional moiety, biodegradable and permanent, designed to be implantable in a mammalian body and intended to block or mitigate the formation of tissue adhesions. The hydrogels of the present invention are characterized by comprising four structural elements: a) a polymeric backbone which defines the overall polymeric morphology, b) linkage groups, c) side chains, and d) biofunctional end groups. The hydrophobicity of the various structural elements are chosen to reduce tissue adhesion and enhance the biofunctional aspect of the end groups. The morphology of these polymers are typically of high molecular weight and have shape to encourage entanglement. Useful structures include branching chains, comb or brush, and dendritic morphologies.Type: GrantFiled: October 1, 2016Date of Patent: July 31, 2018Assignee: BVW Holding AGInventors: Lukas Bluecher, Michael Milbocker
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Patent number: 9480747Abstract: Disclosed are hydrogels polymerized with a biofunctional moiety, biodegradable and permanent, designed to be implantable in a mammalian body and intended to block or mitigate the formation of tissue adhesions. The hydrogels of the present invention are characterized by comprising four structural elements: a) a polymeric backbone which defines the overall polymeric morphology, b) linkage groups, c) side chains, and d) biofunctional end groups. The hydrophobicity of the various structural elements are chosen to reduce tissue adhesion and enhance the biofunctional aspect of the end groups. The morphology of these polymers are typically of high molecular weight and have shape to encourage entanglement. Useful structures include branching chains, comb or brush, and dendritic morphologies.Type: GrantFiled: January 18, 2013Date of Patent: November 1, 2016Assignee: BVW Holding AGInventors: Lukas Bluecher, Michael Milbocker
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Publication number: 20140288582Abstract: An implantable medical device for providing structural support to tissue is described wherein the implant adheres to tissue without the benefit of suture, surgical adhesive and the like. The adherent or localization means is a hemostat or protein polymerizing materials such as oxidized cellulose, alpha cellulose, polyanhydroglucuronic acid and the like. The structure of the hemostat may be fibular (hallow and solid), woven, particulate, and the structure of hemostats in general. These protein polymerization compounds are beneficially attach to at least one side of a planar implant such as a surgical repair mesh, surgical barrier, and any implantable device intended to isolate or strength a layer of mammalian tissue.Type: ApplicationFiled: June 21, 2012Publication date: September 25, 2014Applicant: BVW HOLDING AGInventors: Michael T. Milbocker, Lukas von Bluecher
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Publication number: 20140207251Abstract: Bio-selective textured surfaces are described which mediate foreign body response, bacterial adhesion, and tissue adhesion on devices implanted in a mammalian body. Hierarchical levels of texture, some capable of establishing a Wenzel state others a Cassie state, are employed to interface with living structures, either to promote or discourage a particular biological response/interaction. Since a gaseous state is traditionally required to establish a Cassie or Wenzel state, and gases do not remain long in living tissue, described are tissue/device interactions analogous to the above states with the component normally represented by a gas replaced by a bodily constituent, wherein separation of tissue constituents develops and a desired interaction state evolves.Type: ApplicationFiled: January 18, 2013Publication date: July 24, 2014Applicant: BVW HOLDING AGInventors: Lukas Bluecher, Michael Milbocker
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Publication number: 20140200679Abstract: Bio-adhesive textured surfaces are described which allow implants to be localized within a living body. Hierarchical levels of texture on an implantable medical device, some capable of establishing a Wenzel state and others a Cassie state, are employed to interface with living structures to provide resistance to device migration. Since a gaseous state is traditionally required to establish a Cassie or Wenzel state, and gases do not remain long in living tissue, described are tissue/device interactions analogous to the above states with the component normally represented by a gas replaced by a bodily constituent, wherein separation of tissue constituents develops and an analogous Cassie, Wenzel or Cassie-Wenzel state evolves.Type: ApplicationFiled: January 18, 2013Publication date: July 17, 2014Applicant: BVW HOLDING AGInventors: Lukas Bluecher, Michael Milbocker