Abstract: A method for injecting a therapeutic agent into a target tissue, the method comprising: (a) providing an expandable member; (b) positioning said expandable member in proximity to the target tissue; (c) Introducing the therapeutic agent into the expandable member until a desired pressure is achieved; and (d) creating a plurality of small apertures in the expandable member.

Abstract: A method for injecting a therapeutic agent into a target tissue, the method comprising: (a) providing an expandable member; (b) positioning said expandable member in proximity to the target tissue; (c) Introducing the therapeutic agent into the expandable member until a desired pressure is achieved; and (d) creating a plurality of small apertures in the expandable member.

Abstract: A method for injecting a therapeutic agent into a target tissue, the method comprising: (a) providing an expandable member; (b) positioning said expandable member in proximity to the target tissue; (c) Introducing the therapeutic agent into the expandable member until a desired pressure is achieved; and (d) creating a plurality of small apertures in the expandable member.

Abstract: A method and system for delivering a medicament into tissue, for example via a balloon with small pores. Optionally, the pressure used is high enough to cause jetting, but the pore sizes, pore density, pressure and/or delivery time are such that the jetting do not cause unacceptable tissue damage. Optionally, the pores are smaller than 2 microns, are between 300 and 600 per square centimeter and the pressure is above 8 atmospheres.

Abstract: A system and method for delivering medicament to tissue, using a pulse pressure source and optional pre-pressuring. Optionally, the delivery system is modular and/or adjustable for various applications. Optionally, the treated tissue is a blood vessel wall. Optionally, the delivery system is mechanical.

Abstract: A pressure sensitive valve comprising: (a) an outer balloon adapted for intravascular insertion comprising at least one hole adapted for ejection of a fluid; (b) an inner structure adapted to substantially fill the outer balloon; (c) at least one selectively blockable flow path between the outer balloon and the inner structure, at least some of the at least one flow path in fluid communication with at least one of the at least one hole; (d) an inlet port to the at least one flow path; and (e) a pressure source operable to provide a fluid at least at a selected injection pressure to the inlet port. A flow of the fluid along the at least one selectively blockable flow path to the at least one hole is prevented when the pressure source provides any pressure below the selected injection pressure and a flow of the fluid along the at least one selectively blockable low path to the at least one hole occurs when the pressure source provides pressure at or above the selected injection pressure.

Abstract: A balloon for injecting material into a wall of a hollow organ of a human, comprising: an expandable balloon body having a surface and having an axis; at least one predefined ejection port on said body adapted for ejection of fluid therefrom, in a transaxial direction; and an impulse source configured for and adapted to eject material out of said point at a velocity and shape suitable for mechanically penetrating tissue adjacent said port.

Abstract: A method for injecting a therapeutic agent into a target tissue, the method comprising: (a) providing an expandable member; (b) positioning said expandable member in proximity to the target tissue; (c) Introducing the therapeutic agent into the expandable member until a desired pressure is achieved; and (d) creating a plurality of small apertures in the expandable member.

Abstract: Various anastomotic connectors (400) for attaching two blood vessels are described, including connectors, which comprise a plurality of clip like elements. In some embodiments, each clip like element comprises a flat medallion section (404) and a tearable hook section (402).

Abstract: A sliding surgical clip adapted to connect blood vessel tissue, comprising: an elongate rail leg having a main axis and terminating with a first tissue penetrating tip; and a sliding leg terminating with a second tip and configured to slide along said rail leg towards said first tissue penetrating tip, such that said two tips face each other and engage vascular tissue between them.

Abstract: An anastomotic connector for connecting a graft to a target vessel, comprising a thin collar section (104) adapted to engage a portion of the graft; and a separate spike section (124) adapted to mount on said collar section, and comprising a plurality of spikes (126) each of said spikes (126) adapted to transfix said graft. Preferably, the connector comprises at least one locking element for interlocking said spike section (124), and said collar section (104). Preferably the locking element provides a spring action between the two sections.

Abstract: This invention is a device (500) for sealing a hole in a blood vessel, comprising a ring (504); a plurality of spikes (506) extending from said ring towards a center of said ring, and to first direction along an axis of said ring, said spikes being adapted for engaging a blood vessel; a plurality of tabs (502) extending substantially radially from said ring, wherein rotating said tabs around said ring distorts said ring such that said spikes are rotated in a same direction as said tabs.

Abstract: A cutter (300) adapted for making an aperture in a blood vessel (810) suitable for receiving an anastomotic connector, the cutter comprising a handle a curved element extending from the handle, a sharp tip (306) at the end of the element, the tip (306) adapted for making at least one entry cut in a blood vessel (810) and at least one exit cut in the same blood vessel a distance from the entry cut while a portion of the curved element is substantially within the vessel lumen and a sharp edge (376) along a portion of the convex aspect of the portion, the edge adapted to cut the vessel as the handle is pulled radially away from the lumen.

Abstract: An anastomotic connector (60) for attaching two blood vessels, comprising a cylinder-like portion having a lumen, two ends, and an array of cells elements, and a tissue engaging portion (60) comprising at least one set of spikes (64) wherein at least one spike arranged adjacent one of the two ends of said cylinder-like portion. The connector (60) may comprise at least a second set of spikes (66) adjacent the other of the two ends.

Abstract: A method of performing an anastomosis, comprising, juxtaposing two blood vessels to be anastomosed using an juxtaposition device, to a desired configuration in which at least one vessel is an end vessel; applying an adhesive to said vessels while they are in said configuration, said adhesive being sufficient to ensure both sealing and bonding of said two vessels to each other, and removing said juxtaposition device after said adhesive sufficiently sets.

Abstract: A leg compacting system for compacting inwards a group of legs (228) of an anastomotic connector towards a central location thereof, comprising, a coupler for coupling to a delivery system on which said connector is mounted; and a plurality of leg confiners (820), said leg confiners (820) configured to selectively move in an inwards direction and said confiners configured to have a resting compacted configuration in which a space of between 7 and 1 mm in width is maintained between the innermost leg contacting sections of said confiners such that a graft vessel suitable for mounting on said connector can be passed between said confiners (820).

Abstract: An anastomosis connector comprises a plurality of ring segments (106), together defining a radially expandable ring-like shape (106) having a lumen; at least one pivot bar (114) coupled to at least one of said ring segments (106); at least one spike (109) mounted on said pivot bar (114) and rotatable around said pivot bar (114), wherein radial deformation of said ring-like shape (106) does not substantially directly affect said spike (109) rotational position.

Abstract: A method of accessing a blood vessel, comprising: forming a hole in the blood vessel; mounting a hole closure device onto the blood vessel; accessing the blood vessel through the hole, while the hole closure device is mounted on the blood vessel; and closing the hole by the hole closure device, after accessing the blood vessel through the hole.

Abstract: A fluid-based anastomosis system, including a body, a fluid power source, an actuator powered by said source and at least two elements coupled to said actuator and adapted to perform at least two different relative motions, responsive to serial powering of said actuator.

Abstract: Hole-forming apparatus (1900) for forming a hole in a blood vessel, comprising a penetration shaft (1908), having a tip (1904) adapted to be inserted through a wall of a blood vessel; a tissue holder (1986), configured to hold a portion of said wall, said holder (1986) being activated to perform said holding separately from an insertion of said penetration shaft (1908) through said wall; and a cutting surface (1910) adapted to cut through the wall.