Patents Assigned to c-a-i-r biosciences GmbH
  • Dibenzocycloheptatone derivatives and pharmaceutical agents containing said compounds
    Patent number: 8633312
    Abstract: The present invention relates to compounds of the formula I wherein R1, R2, R3, R4, X and Y have the meanings given in the description. The compounds have an action which is immunomodulating and inhibits or regulates the release of IL-1? and/or TNF-?. They can therefore be used for treatment of diseases connected with a disturbance in the immune system.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: January 21, 2014
    Assignee: c-a-i-r biosciences GmbH
    Inventors: Stefan Laufer, Wolfgang Albrecht
  • Choline and tromethamine salt of licofelone
    Patent number: 8519155
    Abstract: The present invention relates to the choline and tromethamine salt of Licofelone.
    Type: Grant
    Filed: October 30, 2009
    Date of Patent: August 27, 2013
    Assignee: c-a-i-r biosciences GmbH
    Inventors: Wolfgang Albrecht, Hans-Günter Striegel, Stefan Laufer
  • CHOLINE AND TROMETHAMINE SALT OF LICOFELONE
    Publication number: 20120010261
    Abstract: The present invention relates to the choline and tromethamine salt of Licofelone.
    Type: Application
    Filed: October 30, 2009
    Publication date: January 12, 2012
    Applicant: c-a-i-r biosciences GmbH
    Inventors: Wolfgang Albrecht, Hans-Günter Striegel, Stefan Laufer
  • 2-thio-substituted imidazole derivatives and their use in pharmaceutics
    Patent number: 7582660
    Abstract: The invention relates to 2-thio-substituted imidazole derivatives of the formula I in which the radicals R1, R2, R3 and m are as defined in the description. The compounds according to the invention have immunomodulating and/or cytokine-release-inhibiting action and are therefore suitable for treating disorders associated with a disturbed immune system.
    Type: Grant
    Filed: August 20, 2003
    Date of Patent: September 1, 2009
    Assignee: c-a-i-r biosciences GmbH
    Inventors: Stefan Laufer, Hans-Günter Striegel, Karola Tollmann, Wolfgang Albrecht
  • Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
    Patent number: 7579324
    Abstract: This invention features a compound of the following formula: T-(-L-C)m, T is a transportophore, L is a bond or a linker having a molecular weight up to 240 dalton, C is a non-antibiotic therapeutic agent, and m is 1, 2, 3, 4, 5, 6, 7, or 8, in which the transportophore has an immune selectivity ratio of at least 2, the transportophore is covalently bonded to the non-antibiotic therapeutic agent via the bond or the linker, and the compound has an immune selectivity ratio of at least 2.
    Type: Grant
    Filed: February 14, 2003
    Date of Patent: August 25, 2009
    Assignee: c-a-i-r biosciences GmbH
    Inventors: Michael Burnet, Jan-Hinrich Guse, Hans-Jurgen Gutke, Albert Beck, Georgia Tsotsou, Irina Droste-Borel, Jeannette Reichert, Kattie Luyten, Maximilian Busch, Michael Wolff, Moussa Khobzaoui, Simona Margutti, Thomas Meindl, Gene Kim, Laurence Barker
  • Method for subgroup analysis in subjects having or being suspected of having inflammatory disease, use of anti-p38MAPK antibodies, kits and their use
    Publication number: 20090098536
    Abstract: The present invention relates to a method of determining whether a subject having or suspected of having inflammatory disease may potentially benefit from treatment with a p38 mitogen-activated protein kinase (p38MAPK) inhibitor, which method comprises (I) obtaining an inflammatory tissue sample from the subject; and (II) determining whether p38MAPK, in particular p38MAPK?, is expressed in the tissue sample. The present invention further relates to the use of an antibody against the p38MAPK protein for determining whether a subject having or suspected of having inflammatory disease may benefit from treatment with a p38 mitogen-activated protein kinase (p38MAPK) inhibitor; kits for determining from an inflammatory tissue sample whether a subject having or suspected of having inflammatory disease may benefit from treatment with a p38 mitogen-activated protein kinase (p38MAPK) inhibitor; and to the corresponding use of said kit.
    Type: Application
    Filed: October 12, 2007
    Publication date: April 16, 2009
    Applicant: c-a-i-r- biosciences GmbH
    Inventors: Georg Schett, Wolfgang Albrecht, Stefan Laufer