Abstract: The present invention relates to compounds of formula (I) and (IV), and pharmaceutically acceptable salts, tautomers, stereoisomers thereof, which are inhibitors of histone deacetylase (HDAC). The compounds of the present invention are for use in the treatment of disorders that are ameliorated by inhibition of HDAC such as cancer and hemoglobinopathies like ?-thalassemia or sickle cell anemia.
Type:
Grant
Filed:
August 7, 2013
Date of Patent:
June 21, 2016
Assignees:
IRBM-SCIENCE PARK S.P.A., C.N.C.C.S. SCARL COLLEZIONE NAZIONALE DEI COMPOSTI CHIMICI E CENTRO SCREENING
Inventors:
Sergio Altamura, Alberto Bresciani, Giulia Breveglieri, Danilo Fabbrini, Roberto Gambari, Steven Harper, Ralph Laufer, Edith Monteagudo, Emanuela Nizi, Paola Pace, Vincenzo Summa
Abstract: The present invention relates to compounds useful for treating parasitic diseases, which are infectious diseases caused or transmitted by a parasite. Compounds of the invention are particularly active against the causative pathogens in malaria. Such compounds are selective inhibitors of parasitic histone deacetylase (PfHDAC) and suppress the growth of parasites, such as Plasmodium falciparum, at a lower concentration than the concentration required for the inhibition of the growth of mammalian cells.
Type:
Application
Filed:
October 30, 2013
Publication date:
October 22, 2015
Applicants:
IRBM - SCIENCE PARK S.P.A., C.N.C.C.S. SCARL COLLEZIONE NAZIONALE DEI COMPOSTI CHIMICI E CENTRO SCREENING
Inventors:
Sergio ALTAMURA, Ilaria BIANCOFIORE, Alberto BRESCIANI, Federica FERRIGNO, Steven HARPER, Ralph LAUFER, Jesus Maria ONTORIA ONTORIA, Savina MALANCONA, Edith MONTEAGUDO, Emanuela NIZI, Maria Vittoria ORSALE, Simona PONZI, Giacomo PAONESSA, Vincenzo SUMMA, Maria VENEZIANO