Patents Assigned to c/o Enzo Biochem, Inc.
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Publication number: 20090069500Abstract: This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful for labeling probes or targets, including nucleic acids and proteins. These reagents can be usefully applied to protein and nucleic acid probe based assays. They are also applicable to real-time detection processes.Type: ApplicationFiled: January 22, 2004Publication date: March 12, 2009Applicant: Enzo Life Sciences, Inc., c/o Enzo Biochem, Inc.Inventors: Jannis G. Stavrianopoulos, Elazar Rabbani
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Patent number: 7396647Abstract: This invention provides for compositions for use in real time nucleic acid detection processes. Such real time nucleic acid detection processes are carried out with energy transfer elements attached to nucleic acid primers, nucleotides, nucleic acid probes or nucleic acid binding agents. Real time nucleic acid detection allows for the qualitative or quantitative detection or determination of single-stranded or double-stranded nucleic acids of interest in a sample. Other processes are provided by this invention including processes for removing a portion of a homopolymeric sequence, e.g., poly A sequence or tail, from an analyte or library of analytes. Compositions useful in carrying out such removal processes are also described and provided.Type: GrantFiled: September 27, 2005Date of Patent: July 8, 2008Assignee: Enzo Life Science, Inc. c/o Enzo Biochem Inc.Inventors: Elazar Rabbani, Jannis G. Stavrianopoulos, James J. Donegan, Jack Coleman, Dakai Liu
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Patent number: 7323571Abstract: This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful for labeling probes or targets, including nucleic acids and proteins. These reagents can be usefully applied to protein and nucleic acid probe based assays. They are also applicable to real-time detection processes.Type: GrantFiled: January 23, 2004Date of Patent: January 29, 2008Assignee: Enzo Life Sciences, Inc. c/o Enzo Biochem, Inc.Inventors: Jannis G. Stavrianopoulos, Elazar Rabban
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Patent number: 7256299Abstract: This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful for labeling probes or targets, including nucleic acids and proteins. These reagents can be usefully applied to protein and nucleic acid probe based assays. They are also applicable to real-time detection processes.Type: GrantFiled: January 23, 2004Date of Patent: August 14, 2007Assignee: Enzo Life Sciences, Inc. c/o Enzo Biochem, Inc.Inventors: Jannis G. Stavrianopoulos, Elazar Rabbani
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Patent number: 7220854Abstract: The present invention provides a nucleotide having the formula, wherein PM is a phosphate moiety, SM is a ribose or a deoxyribose sugar moiety, and BASE is a pyrimidine, purine or 7-deazapurine moiety. PM is attached to SM at a position independently selected from the 2?, 3?, and 5? positions of SM when the nucleotide is a ribonucleotide, and at a position independently selected from the 3? and 5? positions when the nucleotide is a deoxyribonucleotide. BASE is attached to the 1? position of SM from the N1 position when BASE is a pyrimidine, or the N9 position when BASE is a purine or 7-deazapurine. Sig is a detectable moiety covalently attached to SM directly or through a linkage group. Also provided are an oligo- or polynucleotide comprising at least one such sugar moiety labeled nucleotide, and other compositions including those wherein a polypeptide is terminal ligated or attached to the oligo- or polynucleotide.Type: GrantFiled: June 7, 1995Date of Patent: May 22, 2007Assignee: Enzo Life Sciences, Inc. c/o Enzo Biochem, Inc.Inventors: Dean Engelhardt, Elazar Rabbani, Stanley Kline, Jannis G. Stavrianopoulos, Dollie Kirtikar
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Patent number: 7166478Abstract: This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful for labeling probes or targets, including nucleic acids and proteins. These reagents can be usefully applied to protein and nucleic acid probe based assays. They are also applicable to real-time detection processes.Type: GrantFiled: March 12, 2002Date of Patent: January 23, 2007Assignee: Enzo Life Sciences, Inc., c/o Enzo Biochem, Inc.Inventors: Jannis G. Stavrianopoulos, Elazar Rabbani
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Patent number: 7163796Abstract: This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful for labeling probes or targets, including nucleic acids and proteins. These reagents can be usefully applied to protein and nucleic acid probe based assays. They are also applicable to real-time detection processes.Type: GrantFiled: January 23, 2004Date of Patent: January 16, 2007Assignees: Enzo Life Sciences, Inc., c/o Enzo Biochem, Inc.Inventors: Jannis G. Stavrianopoulos, Elazar Rabbani
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Publication number: 20060172308Abstract: This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful for labeling probes or targets, including nucleic acids and proteins. These reagents can be usefully applied to protein and nucleic acid probe based assays. They are also applicable to real-time detection processes.Type: ApplicationFiled: January 22, 2004Publication date: August 3, 2006Applicant: Enzo Life Sciences, Inc., c/o Enzo Biochem, Inc.Inventors: Jannis Stavrianopoulos, Elazar Rabbani
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Publication number: 20060172310Abstract: This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention.Type: ApplicationFiled: July 27, 2004Publication date: August 3, 2006Applicant: Enzo Life Sciences, Inc., c/o Enzo Biochem, Inc.Inventors: Elazar Rabbani, Jannis Stavrianopoulos, James Donegan, Jack Coleman
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Patent number: 7064197Abstract: Nucleic acids are fixed or immobilized to non-porous solid supports (substrates), and include systems containing such supports and arrays with fixed or immobilized nucleic acids. These compositions are useful for nucleic acid analyses and a host of applications, including, for example, detection, mutational analysis and quantification. The non-porous solid supports can be transparent or translucent, and the surfaces can be treated with agents to fix or immobilize the nucleic acids. Such agents include, for example, amine providing compounds, epoxy compounds and acid solutions. The fixed or immobilized nucleic acids can be unlabeled, or labeled with at least one non-radioactive signaling moiety, such as the case when the nucleic acids are double-stranded.Type: GrantFiled: June 7, 1995Date of Patent: June 20, 2006Assignee: Enzo Life Sciences, Inc. c/o Enzo Biochem, Inc.Inventors: Elazar Rabbani, Jannis G. Stavrianopoulos, Dollie Kirtikar, Kenneth H. Johnston, Barbara E. Thalenfeld
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Publication number: 20060040272Abstract: This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention.Type: ApplicationFiled: July 29, 2004Publication date: February 23, 2006Applicant: Enzo Life Sciences, Inc., c/o Enzo Biochem, Inc.Inventors: Elazar Rabbani, Jannis Stavrianopoulos, James Donegan, Jack Coleman
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Patent number: 6992180Abstract: The present invention provides a nucleotide having the formula, Sig-PM-SM-BASE wherein PM is a phosphate moiety, SM is a sugar moiety and BASE is a pyrimidine, purine or 7-deazapurine moiety. PM is attached to the 3? or the 5? position of the sugar moiety when the nucleotide is a deoxyribonucleotide and at the 2?, 3? or 5? position when the nucleotide is a ribonucleotide. BASE is attached to the 1? position of SM from the N1 position when BASE is a pyrmidine or the N9 position when BASE is a purine or 7-deazapurine. Sig is covalently attached to PM directly or via a chemical linkage, and represents a detectable moiety covalently attached to SM directly or through a linkage group. Also provided are an oligo- or polynucleotide comprising at least one such phosphate-moiety labeled nucleotide, and other compositions including those wherein a polypeptide is terminally ligated or attached to the oligo- or polynucleotide.Type: GrantFiled: June 7, 1995Date of Patent: January 31, 2006Assignee: Enzo Life Sciences, Inc. c/o Enzo Biochem, Inc.Inventors: Dean Engelhardt, Elazar Rabbani, Stanley Kline, Janes G. Stavrianopoulos, Dollie Kirtikar
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Publication number: 20050277112Abstract: This invention provides novel processes for therapeutic applications, including the treatment of subjects carrying infectious agents or having impaired autoimmunity or impaired immune condition. The therapeutic applications disclosed herein are also directed at the treatment of cancerous subjects with malignant tumors containing cancerous cells or malignant or cancerous cells. Vaccination processes for preventing infections in subjects are also provided. The novel processes comprise introducing into or adminstering to a subject one or more antigens, or trained or adopted immune cells. These antigens or immune cells are capable of establishing or increasing at least one first specific immune response and decreasing at least one second specific immune response. Such responses include components, such as cellular immune reaction elements, humoral immune reaction elements and cytokines, the latter also encompassing interferons and lymphokines. Useful compositions are also provided by this invention.Type: ApplicationFiled: December 8, 2003Publication date: December 15, 2005Applicant: Enzo Therapeutics, Inc., c/o Enzo Biochem, Inc.Inventors: Yaron Ilan, Elazar Rabbani, Dean Engelhardt, Israel Gotsman, James Donegan
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Publication number: 20050260226Abstract: This invention provides novel processes for therapeutic applications, including the treatment of subjects carrying infectious agents or having impaired autoimmunity or impaired immune condition. The therapeutic applications disclosed herein are also directed at the treatment of cancerous subjects with malignant tumors containing cancerous cells or malignant or cancerous cells. Vaccination processes for preventing infections in subjects are also provided. The novel processes comprise introducing into or adminstering to a subject one or more antigens, or trained or adopted immune cells. These antigens or immune cells are capable of establishing or increasing at least one first specific immune response and decreasing at least one second specific immune response. Such responses include components, such as cellular immune reaction elements, humoral immune reaction elements and cytokines, the latter also encompassing interferons and lymphokines. Useful compositions are also provided by this invention.Type: ApplicationFiled: December 8, 2003Publication date: November 24, 2005Applicant: Enzo Therapeutics, Inc., c/o Enzo Biochem, Inc.Inventors: Yaron Ilan, Elazar Rabbani, Dean Engelhardt, Israel Gotsman, James Donegan
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Publication number: 20050260560Abstract: This invention provides novel processes for therapeutic applications, including the treatment of subjects carrying infectious agents or having impaired autoimmunity or impaired immune condition. The therapeutic applications disclosed herein are also directed at the treatment of cancerous subjects with malignant tumors containing cancerous cells or malignant or cancerous cells. Vaccination processes for preventing infections in subjects are also provided. The novel processes comprise introducing into or adminstering to a subject one or more antigens, or trained or adopted immurie cells. These antigens or immune cells are capable of establishing or increasing at least one first specific immune response and decreasing at least one second specific immune response. Such responses include components, such as cellular immune reaction elements, humoral immune reaction elements and cytokines, the latter also encompassing interferons and lymphokines. Useful compositions are also provided by this invention.Type: ApplicationFiled: December 8, 2003Publication date: November 24, 2005Applicant: Enzo Therapeutics, Inc., c/o Enzo Biochem, Inc.Inventors: Yaron Ilan, Elazar Rabbani, Dean Engelhardt, Isarel Gotsman, James Donegan
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Publication number: 20050260227Abstract: This invention provides novel processes for therapeutic applications, including the treatment of subjects carrying infectious agents or having impaired autoimmunity or impaired immune condition. The therapeutic applications disclosed herein are also directed at the treatment of cancerous subjects with malignant tumors containing cancerous cells or malignant or cancerous cells. Vaccination processes for preventing infections in subjects are also provided. The novel processes comprise introducing into or adminstering to a subject one or more antigens, or trained or adopted immune cells. These antigens or immune cells are capable of establishing or increasing at least one first specific immune response and decreasing at least one second specific immune response. Such responses include components, such as cellular immune reaction elements, humoral immune reaction elements and cytokines, the latter also encompassing interferons and lymphokines. Useful compositions are also provided by this invention.Type: ApplicationFiled: December 8, 2003Publication date: November 24, 2005Applicant: Enzo Therapeutics, Inc., c/o Enzo Biochem, Inc.Inventors: Yaron Ilan, Elazar Rabbani, Dean Engelhardt, Israel Gotsman, James Donegan
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Publication number: 20050202456Abstract: This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention.Type: ApplicationFiled: July 29, 2004Publication date: September 15, 2005Applicant: Enzo Life Sciences, Inc., c/o Enzo Biochem, Inc.Inventors: Elazar Rabbani, Jannis Stavrianopoulos, James Donegan, Jack Coleman
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Publication number: 20050170370Abstract: This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention.Type: ApplicationFiled: July 29, 2004Publication date: August 4, 2005Applicant: Enzo Life Sciences, Inc., c/o Enzo Biochem, Inc.Inventors: Elazar Rabbani, Jannis Stavrianopqulos, James Donegan, Jack Coleman
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Publication number: 20050136074Abstract: This invention provides novel processes for therapeutic applications, including the treatment of subjects carrying infectious agents or having impaired autoimmunity or impaired immune condition. The therapeutic applications disclosed herein are also directed at the treatment of cancerous subjects with malignant tumors containing cancerous cells or malignant or cancerous cells. Vaccination processes for preventing infections in subjects are also provided. The novel processes comprise introducing into or adminstering to a subject one or more antigens, or trained or adopted immune cells. These antigens or immune cells are capable of establishing or increasing at least one first specific immune response and decreasing at least one second specific immune response. Such responses include components, such as cellular immune reaction elements, humoral immune reaction elements and cytokines, the latter also encompassing interferons and lymphokines. Useful compositions are also provided by this invention.Type: ApplicationFiled: December 8, 2003Publication date: June 23, 2005Applicant: Enzo Therapeutics, Inc., c/o Enzo Biochem, Inc.Inventors: Yaron Ilan, Elazar Rabbani, Dean Engelhardt, Israel Gotsman, James Donegan
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Publication number: 20050118196Abstract: This invention provides novel processes for therapeutic applications, including the treatment of subjects carrying infectious agents or having impaired autoimmunity or impaired immune condition. The therapeutic applications disclosed herein are also directed at the treatment of cancerous subjects with malignant tumors containing cancerous cells or malignant or cancerous cells. Vaccination processes for preventing infections in subjects are also provided. The novel processes comprise introducing into or adminstering to a subject one or more antigens, or trained or adopted immune cells. These antigens or immune cells are capable of establishing or increasing at least one first specific immune response and decreasing at least one second specific immune response. Such responses include components, such as cellular immune reaction elements, humoral immune reaction elements and cytokines, the latter also encompassing interferons and lymphokines. Useful compositions are also provided by this invention.Type: ApplicationFiled: December 8, 2003Publication date: June 2, 2005Applicant: Enzo Therapeutics, Inc. c/o Enzo Biochem, Inc.Inventors: Yaron Ilan, Elazar Rabbani, Dean Engelhardt, Israel Gotsman, James Donegan