Abstract: A self-sealing vascular graft with kink resistance is described. The vascular graft includes a substrate that can be a PTFE, having a self-sealing region that may include several layers of material. The central section of the vascular graft may be constructed differently from surrounding self-sealing regions, in order to provide kink resistance following the clamping of the graft. Also described is a graft with a flared cuff attached to one or both ends, the attachment or transition region including reinforcement beading.

Abstract: A reinforced multi-lumen catheter and method of manufacturing the same. An assembly for manufacturing the multi-lumen catheter includes a catheter body substrate including a septum, one or more mandrels, a reinforcing element and one or more sleeves. The septum may have a distal region with a cross-sectional thickness greater than that of a proximal region. The septum can be separately formed. The septum can be split along a length of the distal region. The reinforcing element can be positioned over at least a proximal region of the catheter body substrate.

Abstract: Method and apparatus for treating conductive irregularities in the heart, particularly atrial fibrillation and accessory path arrythmias. An ablative catheter is positioned relative to an inter-atrial electrical pathway, or a vicinity of accessory paths such as the coronary sinus or fossa ovalis, and actuated to form a lesion that partially or completely blocks electrical conduction in at least one direction along the pathway.

Abstract: Embodiments of the invention relate to electrophysiology catheters and methods of using the same. According to one embodiment, the catheter includes a braided conductive member at its distal end that can be radially expanded, for example using a mandrel slidably disposed within a shaft of the catheter. According to another embodiment, the catheter comprises a tip portion constructed of an elastomeric material. According to a further embodiment, the catheter includes a braided conductive member wherein a thermocouple is formed using one filament of the braided conductive member and one thermocouple wire. Other embodiments of the invention relate to a handle for use with a catheter and methods of using the same. According to one embodiment, the handle comprises a thumbwheel coupled to a housing, a spring disposed within the housing in contact with the thumbwheel, and means for increasing compression of the spring to increase rotational friction on the thumbwheel.

Abstract: The present invention provides an endoscopic accessory control system that resides externally of the endoscope. The system comprises the endoscopic accessory with a working end to be placed at the distal end of the endoscope, a control sheath extending proximally external to the endoscope and a control handle joined to the proximal end of the control sheath. The control handle is slidably mounted to the exterior surface of the endoscope shaft and is configured to permit grasping of both the shaft and the handle. With the control handle and endoscope shaft grasped with one hand, the other hand of the user is left free to manipulate the endoscope distal tip controls. Additionally, the external arrangement of the control sheath leaves the working channel of the endoscope free for use of accessories or operations.

Abstract: The invention concerns a method of providing a stent with a radiopaque marker comprising the steps of: i) providing in the stent a radiopaque marker carrier portion; ii) sleeving the carrier portion with radiopaque material, with an insulating surface between the carrier and the marker material, and iii) plastically deforming material within the sleeve of radiopaque material, to secure the sleeve on the carrier portion. The invention further concerns a stent with a radiopaque marker, the stent exhibiting a generally annular form with luminal and abluminal major surfaces, the marker also exhibiting opposed major luminal and abluminal surfaces characterised in that i) the marker envelops a carrier portion of the stent and is electrically insulated from it; ii) portions of the material of the marker which exhibit evidence of plastic deformation secure the marker on the carrier portion.

Abstract: A valved sheath introducer for venous cannulation, including a valve, sheath, handle and cap. The valve is configured to permit safe introduction and removal of medical instruments through the sheath introducer. The valve may have one or more anchoring members and a thickened central portion through which a slit is formed. The central portion may have one or more concave surfaces and the slit can be angled with respect to the top surface of the valve. The cap is attached to the handle, compressing a portion of the valve therebetween.

Abstract: An endotracheal device may include an elongated body member having a first end and a second end, first and second lumen defined by the body member, and a funnel member proximal the second end. The first lumen may extend from a first opening in the first end to a first opening in the second end The second lumen may extend from a second opening in the first end to at least one point in a wall of the body member proximal the second end. The tunneling member may be configured to direct fluid toward at least one of the points in the wall.

Abstract: An ACS therapy system for continuously monitoring Intra-Abdominal Pressure (IAP) and preventing the onset of ACS. The automated ACS therapy system includes a urine withdrawal device, an IAP regulation circuit, an IAP monitor connected to the urine withdrawal device to supply an IAP value to the IAP regulation circuit, and an abdominal fluid removal device The abdominal fluid removal device may be connected to an active suction device, which withdraws fluid from the abdominal cavity through the abdominal fluid removal device when activated by the IAP regulation circuit. Based on the IAP value, the IAP regulation circuit may send a control signal that controls the active suction device to turn on and drain fluid from the abdominal cavity. When the IAP value reaches certain levels, the IAP regulation circuit may cause the active suction device to be turned off.

Abstract: Junctions of ablation electrodes and catheters are disclosed. Electrophysiology catheter systems include a recessed region such as a channel at a junction of an electrode and a catheter shaft. The channel can help to reduce electrode hotspots, energy density and/or blood coagulation at the junction. The channel may be incorporated in a distal tip electrode or a ring electrode.

Abstract: A stenting ring made of a tube or rolled-up sheet that has a characteristic wall thickness. The ring defines a lumen and is equipped with at least one marker made of a material different from that of the ring. The ring is expansible from a radially compact disposition with a relatively small circumference to a radially expanded disposition with a relatively large circumference. The ring exhibits in the compact disposition a serpentine arrangement of succeeding struts lying in alternate opposite directions to the longitudinal axis of the lumen. The marker has a thickness in the radial direction of the ring that is less than the characteristic wall thickness, and has a width that extends circumferentially around an arc of the ring. The marker is attached to the ring at a zone located at a point intermediate in the extent of said arc.

Abstract: A blood filter device for placement in a blood vessel including a plurality of anchor members disposed radially and extending angularly about a first hub. A filter basket is preferably positioned upstream from the anchor members. The anchor members each include a hook configured to penetrate the vessel wall to prevent longitudinal movement due to blood flow. The filter basket is made up of a number of filter members configured to retain blood clots within the basket without completely blocking blood flow or applying additional force to vessel walls. Portions of the filter members may project radially outward to position the basket near the vessel centerline, but the filter basket preferably does not include hooks or anchors for anchoring the filter basket to the blood vessel.

Abstract: A wall, for example the wall of a vascular graft, has multiple channels within it. The channels may be used to hold drugs or reinforcing fibers. The channels may have a predetermined roughness. The channels may be formed by coextrusion using a soluble material, for example, to define the channels and then dissolving them to open the channels in the extrudate.

Abstract: A filter having a first set of members and a second set of members defining a trap sized to fit into a blood vessel. Each of the first and second members are configured to resiliently extend from the trap. At least one of the first set of members includes a first surface for engaging the vessel wall such that the at least one of the first set of members resists downstream movement within the vessel. At least one of the second set of members includes a second surface for engaging the vessel wall such that the at least one second member resists upstream movement within the vessel.

Abstract: A method of loading a self-expanding stent into a delivery sheath configured to retain the stent in a radially compressed pre-deployment configuration, including the steps of radially compressing the stent from a relaxed outside diameter d0 to a compressed outside diameter d1, providing a loading sheath with an inner diameter d2, where d0>d2>d1, translating the stent relative to the sheath, whereby the stent is accommodated within the lumen of the loading sheath, providing a delivery sheath with an inner diameter d3, where d0>d3>d2, advancing the loading sheath, containing the stent, into the lumen of the delivery sheath, and deploying the stent into the lumen of the delivery sheath.

Abstract: A high aspect ratio biopsy needle achieves reliable performance with large solid sample size by means of a variety of features and combinations thereof, including support to prevent bending, reinforcement of the needle, and cutting edges arranged to resist deformation.

Abstract: An embolus filter introducer system has a symmetric introducer sheath with a filter inside. The introducer sheath can be attached at either end to a deployment actuator. The deployment actuator can thereby be used to push the filter out of the introducer sheath. Since the sheath can be oriented in a selectable direction, so can the filter, allowing the sheath to be introduced via a jugular or femoral approach to the vena cava.

Abstract: Tissue markers, systems for marking tissue, and methods of using tissue markers. A tissue marker may have a body with a first surface and a second surface, a plurality of coupling sites, and a plurality of elongate members. The tissue marker may include a remotely visible material. The tissue marker may have a delivery configuration that is different from a deployed configuration.

Abstract: A stent-graft, including a generally tubular vascular graft of biocompatible material, and a plurality of bio-resorbable discrete annular members spaced apart along a longitudinal axis of the vascular graft and attached thereto.

Abstract: An implantable prosthesis, including a generally tubular substrate and a continuous shape memory member disposed over the outer surface of the substrate. The shape memory member may include a series of zig-zag struts alternating between a first strut with a first length and a second strut with a second length different from the first length. A graft member may be positioned over the substrate and shape memory member.