Abstract: A method and system for blockchain-based medicine-taking management for a clinical trial subject are disclosed. The method for managing clinical trial medicine-taking comprises the steps of: providing a notification for managing medication for a clinical trial medicine through a medication management app; receiving a medication log of the clinical trial subject by scanning a QR code on the clinical trial medicine through the medication management application; storing the received medication log in a blockchain as medication management information of the clinical trial subject; and verifying the validity of the medication log by using the blockchain.